Sub-logarithmic Distributed Oblivious RAM with Small Block Size

Oblivious RAM (ORAM) is a cryptographic primitive that allows a client to securely execute RAM programs over data that is stored in an untrusted server. Distributed Oblivious RAM is a variant of ORAM, where the data is stored in $m>1$ servers. Extensive research over the last few decades have succeeded to reduce the bandwidth overhead of ORAM schemes, both in the single-server and the multi-server setting, from $O(\sqrt{N})$ to $O(1)$. However, all known protocols that achieve a sub-logarithmic overhead either require heavy server-side computation (e.g. homomorphic encryption), or a large block size of at least $\Omega(\log^3 N)$. In this paper, we present a family of distributed ORAM constructions that follow the hierarchical approach of Goldreich and Ostrovsky [GO96]. We enhance known techniques, and develop new ones, to take better advantage of the existence of multiple servers. By plugging efficient known hashing schemes in our constructions, we get the following results: 1. For any $m\geq 2$, we show an $m$-server ORAM scheme with $O(\log N/\log\log N)$ overhead, and block size $\Omega(\log^2 N)$. This scheme is private even against an $(m-1)$-server collusion. 2. A 3-server ORAM construction with $O(\omega(1)\log N/\log\log N)$ overhead and a block size almost logarithmic, i.e. $\Omega(\log^{1+\epsilon}N)$. We also investigate a model where the servers are allowed to perform a linear amount of light local computations, and show that constant overhead is achievable in this model, through a simple four-server ORAM protocol

Do Israelis understand the Hebrew bible?

The Hebrew Bible should be taught like a foreign language in Israel too, argues Ghil'ad Zuckermann, inter alia endorsing Avraham Ahuvia’s recently-launched translation of the Old Testament into what Zuckermann calls high-register 'Israeli'. According to Zuckermann, Tanakh RAM fulfills the mission of 'red 'el ha'am' not only in its Hebrew meaning (Go down to the people) but also – more importantly – in its Yiddish meaning ('red' meaning 'speak!', as opposed to its colorful communist sense). Ahuvia's translation is most useful and dignified. Given its high register, however, Zuckermann predicts that the future promises consequent translations into more colloquial forms of Israeli, a beautifully multi-layered and intricately multi-sourced language, of which to be proud.Ghil'ad Zuckerman

Co-occurrence of outlet impingement syndrome of the shoulder and restricted range of motion in the thoracic spine - a prospective study with ultrasound-based motion analysis

<p>Abstract</p> <p>Background</p> <p>Shoulder complaints, and especially the outlet-impingement syndrome, are a common condition. Among other things, poor posture has been discussed as a cause. A correlation between impingement syndrome and restricted mobility of the thoracic spine (T) has been described earlier, but there has been no motion analysis of the thoracic spine to show these correlations. In the present prospective study, we intended to find out whether there is a significant difference in the thoracic sagittal range of motion (ROM) between patients with a shoulder outlet impingement syndrome and a group of patients who had no shoulder pathology. Secondly, we wanted to clarify whether Ott's sign correlates with ultrasound topometric measurements.</p> <p>Methods</p> <p>Two sex- and age-matched groups (2 × n = 39) underwent a clinical and an ultrasound topometric examination. The postures examined were sitting up straight, sitting in maximal flexion and sitting in maximal extension. The disabilities of the arm, shoulder and hand (DASH) score (obtained by means of a self-assessment questionnaire) and the Constant score were calculated. Lengthening and shortening of the dorsal projections of the spine in functional positions was measured by tape with Ott's sign.</p> <p>Results</p> <p>On examination of the thoracic kyphosis in the erect seated posture there were no significant differences between the two groups (p = 0.66). With ultrasound topometric measurement it was possible to show a significantly restricted segmental mobility of the thoracic spine in the study group compared with the control group (p = 0.01). An in-depth look at the mobility of the subsegments T1-4, T5-8 and T9-12 revealed that differences between the groups in the mobility in the lower two sections of the thoracic spine were significant (T5-8: p = 0.03; T9-12: p = 0.02). The study group had an average Constant score of 35.1 points and the control group, 85.5 (p < 0.001). On the DASH score the patient group reached 34.2 points and the control group, 1.4 (p < 0.001). The results of Ott's sign differed significantly between the two collectives (p = 0.0018), but showed a weak correlation with the ultrasound topometric measurements (study group flexion/extension: r = 0.36/0.43, control group flexion/extension: r = 0.29/0.26).</p> <p>Conclusion</p> <p>The mobility of the thoracic spine should receive more attention in the diagnosis and therapy of patients with shoulder outlet impingement syndrome.</p

3-D struktura serumske paraoksonaze 1 objašnjava njezinu aktivnost, stabilnost, topljivost i kristalizaciju

Serum paraoxonases (PONs) exhibit a wide range of physiologically important hydrolytic activities, including drug metabolism and detoxification of nerve gases. PON1 and PON3 reside on high-density lipoprotein (HDL) (the “good cholesterol”), and are involved in the alleviation of atherosclerosis. Members of the PON family have been identified not only in mammals and other vertebrates, but also in invertebrates. We earlier described the first crystal structure of a PON family member, a directly-evolved variant of PON1, at 2.2 Å resolution. PON1 is a 6-bladed beta-propeller with a unique active-site lid which is also involved in binding to HDL. The 3-D structure, taken together with directed evolution studies, permitted analysis of mutations which enhanced the stability, solubility and crystallizability of this PON1 variant. The structure permits a detailed description of PON1’s active site and suggests possible mechanisms for its catalytic activity on certain substrates.Serumske paraoksonaze (PONs) imaju široki raspon fiziološki važnih hidrolitičkih aktivnosti uključujući metabolizam lijekova i detoksikaciju nervnih plinova. PON1 i PON3 smještene su na lipoproteinima visoke gustoće (engl. high-density lipoprotein; HDL - “dobri kolesterol”) i uključene su u ublažavanje ateroskleroze. Članovi skupine PON identificirani su ne samo u sisavaca i drugih kralježnjaka već i kod beskralješnjaka. Prije smo opisali prvu kristalnu strukturu člana PON skupine, direktno razrađenu varijantu PON1 pri rezoluciji 2,2 Å. PON1 je beta-propeler sa šest lopatica s jedinstvenim poklopcem aktivnog mjesta, koji je tako|er uključen u vezanje na HDL. 3-D struktura, gledana zajedno s direktnim razvojnim istraživanjima, omogućila je analizu mutacija koje povećavaju stabilnost, topljivost i kristalizaciju te PON1 varijante. Struktura dopušta detaljan opis aktivnog mjesta PON1 i sugerira moguće mehanizme za njezinu katalitičku aktivnost prema odre|enim supstratima

3PC ORAM with Low Latency, Low Bandwidth, and Fast Batch Retrieval

Multi-Party Computation of Oblivious RAM (MPC ORAM) implements secret-shared random access memory in a way that protects access pattern privacy against a threshold of corruptions. MPC ORAM enables secure computation of any RAM program on large data held by different entities, e.g. MPC processing of database queries on a secret-shared database. MPC ORAM can be constructed by any (client-server) ORAM, but there is an efficiency gap between known MPC ORAM\u27s and ORAM\u27s. Current asymptotically best MPC ORAM is implied by an MPC friendly variant of Path-ORAM called Circuit-ORAM, due to Wang et al. However, using garbled circuit for Circuit-ORAM\u27s client implies MPC ORAM which matches Path-ORAM in rounds but increases bandwidth by \Omega(kappa) factor, while using GMW or BGW protocols implies MPC ORAM which matches Path-ORAM in bandwidth, but increases round complexity by \Omega(log n loglog n) factor, for kappa the security parameter and n the memory size. In this paper we bridge the gap between MPC ORAM and client-server ORAM by showing a specialized 3PC ORAM protocol, i.e. MPC ORAM for 3 parties tolerating 1 fault, which uses only symmetric ciphers and asymptotically matches client-server Path-ORAM in round complexity and for large records also in bandwidth. Our 3PC ORAM also allows for fast pipelined processing: With post- poned clean-up it processes b=O(log n) accesses in O(b+log n) rounds with O(D+poly(log n)) bandwidth per item, where D is record size

Fitness efficacy of vibratory exercise compared to walking in postmenopausal women

In this study, we compared the efficacy of 8 months of low-frequency vibration and a walk-based program in health-related fitness. Twenty-seven postmenopausal women were randomly assigned into two groups: whole-body vibration (WBV) group (n = 18) performed three times/week a static exercise on a vibration platform (6 sets of 1-min with 1 min of rest, with a 12.6 Hz of frequency and an amplitude of 3 mm); walk-based program (WP) group (n = 18) performed three times/week a 60-min of walk activity at 70-75% of maximal heart rate. A health-related battery of tests was applied. Maximal unilateral concentric and eccentric isokinetic torque of the knee extensors was recorded by an isokinetic dynamometer. Physical fitness was measured using the following tests: vertical jump test, chair rise test and maximal walking speed test over 4 m. Maximal unilateral isokinetic strength was measured in the knee extensors in concentric actions at 60 and 300 degrees /s, and eccentric action at 60 degrees /s. After 8 months, the WP improved the time spent to walk 4 m (20%) and to perform the chair rise test (12%) compared to the WBV group (P = 0.006, 0.002, respectively). In contrast, the comparison of the changes in vertical jump showed the higher effectiveness of the vibratory exercise in 7% (P = 0.025). None of exercise programs showed change on isokinetic measurements. These results indicate that both programs differed in the main achievements and could be complementary to prevent lower limbs muscle strength decrease as we age [ISRCTN76235671]

Carbon-Nanotube-Embedded Hydrogel Sheets for Engineering Cardiac Constructs and Bioactuators

We engineered functional cardiac patches by seeding neonatal rat cardiomyocytes onto carbon nanotube (CNT)-incorporated photo-cross-linkable gelatin methacrylate (GelMA) hydrogels. The resulting cardiac constructs showed excellent mechanical integrity and advanced electrophysiological functions. Specifically, myocardial tissues cultured on 50 μm thick CNT-GelMA showed 3 times higher spontaneous synchronous beating rates and 85% lower excitation threshold, compared to those cultured on pristine GelMA hydrogels. Our results indicate that the electrically conductive and nanofibrous networks formed by CNTs within a porous gelatin framework are the key characteristics of CNT-GelMA leading to improved cardiac cell adhesion, organization, and cell–cell coupling. Centimeter-scale patches were released from glass substrates to form 3D biohybrid actuators, which showed controllable linear cyclic contraction/extension, pumping, and swimming actuations. In addition, we demonstrate for the first time that cardiac tissues cultured on CNT-GelMA resist damage by a model cardiac inhibitor as well as a cytotoxic compound. Therefore, incorporation of CNTs into gelatin, and potentially other biomaterials, could be useful in creating multifunctional cardiac scaffolds for both therapeutic purposes and in vitro studies. These hybrid materials could also be used for neuron and other muscle cells to create tissue constructs with improved organization, electroactivity, and mechanical integrity.United States. Army Research Office. Institute for Soldier NanotechnologiesNational Institutes of Health (U.S.) (HL092836)National Institutes of Health (U.S.) (EB02597)National Institutes of Health (U.S.) (AR057837)National Institutes of Health (U.S.) (HL099073)National Science Foundation (U.S.) (DMR0847287)United States. Office of Naval Research (ONR PECASE Award)United States. Office of Naval Research (Young Investigator award)National Research Foundation of Korea (grant (NRF-2010-220-D00014)