MONITORING OF DRUG SAFETY IN CLINICAL PRACTICE

The results of work on identification and registration of complications of medicinal therapy in medical institutions of the Irkutsk region showed that that the frequency of undesirable medicinal reactions in patients made from 10 to 30 %. The standard scheme of antibacterial therapy results in resistance of pathogenetic flora. Hospital patients have great possibility of being infected with microorganisms, the so-called hospital strains (bacteria). The drug safety monitoring showed the necessity of the policing of prescribing of cardiovascular, antibacterial and antiglaucoma drugs

The interchangeability of drugs from line items of pharmaceutical compliance and clinical efficiency and safety

Questions of replacement of original medicines with generic are discussed. The sintesation of identical medicine is a complex challenge from the technological point of view. It is caused by distinctions in production of substances, influence of the variable pharmaceutical factors giving change of the size of particles, a different amorphous forms, a deviation of structure and quantitative content of impurity. Auxiliary substantion characteristics of a production process of ready dosage forms matter. Data on pharmacokinetic equivalence of each generic to original are necessary. For carrying out pharmacotherapy original medicine which receive as a result of the researches executed under the regulated protocol needs data on comparative therapeutic efficiency and shipping the generic of drugs

The geochemical features of ores and technosoils of tailing gold-molybdenum mine Davenda in East Transbaikalia

New data on the mineral and chemical composition of the ore, host rocks and technosoils of tailings gold-molybdenum deposit Davenda are outlined. The mineral composition of the ore (%): quartz (96), molybdenite (1, but on average 0.26), pyrite (7), chalcopyrite (2), sphalerite (0.07), galena (to.1), sulphosalts (0.02), bismuthinite (0.2), scheelite (up to 0.02), tungsten (up to 0.01), bornite (0.03), tetradymite (to 0.001) emplektite (rare occurrences) and gold (up to1817g/t). In the oxidation zone developed various sulfates, including large (up to10 cm) gypsum crystals, chalkanthite, malachite, azurite, brochantite, molybdenite, ferrimolybdite. The contents of the main chemical elements, which compose technosoils of tailing, exeed their clarks. Exceptions are zinc, tin, and yttrium. Especially high concentration factors for arsenic, bismuth and molybdenum, which indicates the imperfection of applied technologies of the ores enrichment. The distribution of chemical elements in the geotechnogenic system: productive mineral complex (ore + host rock)→soil→technosoils →plants. Revealed the share of Mo, Zn, Cu, Pb mobile form, in technosoils. Identified acid-base characteristics of technosoils. It was found that the most important of the mobile forms is a water-acid-ion exchange, to a much lesser extent - organic elements