2,860 research outputs found
Particles in RSOS paths
We introduce a new representation of the paths of the Forrester-Baxter RSOS
models which represents the states of the irreducible modules of the minimal
models M(p',p). This representation is obtained by transforming the RSOS paths,
for the cases p> 2p'-2, to new paths for which horizontal edges are allowed at
certain heights. These new paths are much simpler in that their weight is
nothing but the sum of the position of the peaks. This description paves the
way for the interpretation of the RSOS paths in terms of fermi-type charged
particles out of which the fermionic characters could be obtained
constructively. The derivation of the fermionic character for p'=2 and p=kp'+/-
1 is outlined. Finally, the particles of the RSOS paths are put in relation
with the kinks and the breathers of the restricted sine-Gordon model.Comment: 15 pages, few typos corrected, version publishe
Awareness Of Racial And Ethnic Health Disparities Has Improved Only Modestly Over A Decade
Abstract available at publisher's web site.http://dx.doi.org/10.1377/hlthaff.2010.070
N-terminal pro-B-type natriuretic peptide and the prediction of primary cardiovascular events: results from 15-year follow-up of WOSCOPS
<b>Aims:</b>To test whether N-terminal pro-B-type natriuretic peptide (NT-proBNP) was independently associated with, and improved the prediction of, cardiovascular disease (CVD) in a primary prevention cohort.
<b>Methods and results:</b> In the West of Scotland Coronary Prevention Study (WOSCOPS), a cohort of middle-aged men with hypercholesterolaemia at a moderate risk of CVD, we related the baseline NT-proBNP (geometric mean 28 pg/mL) in 4801 men to the risk of CVD over 15 years during which 1690 experienced CVD events. Taking into account the competing risk of non-CVD death, NT-proBNP was associated with an increased risk of all CVD [HR: 1.17 (95% CI: 1.11â1.23) per standard deviation increase in log NT-proBNP] after adjustment for classical and clinical cardiovascular risk factors plus C-reactive protein. N-terminal pro-B-type natriuretic peptide was more strongly related to the risk of fatal [HR: 1.34 (95% CI: 1.19â1.52)] than non-fatal CVD [HR: 1.17 (95% CI: 1.10â1.24)] (P= 0.022). The addition of NT-proBNP to traditional risk factors improved the C-index (+0.013; P < 0.001). The continuous net reclassification index improved with the addition of NT-proBNP by 19.8% (95% CI: 13.6â25.9%) compared with 9.8% (95% CI: 4.2â15.6%) with the addition of C-reactive protein. N-terminal pro-B-type natriuretic peptide correctly reclassified 14.7% of events, whereas C-reactive protein correctly reclassified 3.4% of events. Results were similar in the 4128 men without evidence of angina, nitrate prescription, minor ECG abnormalities, or prior cerebrovascular disease.
<b>Conclusion:</b> N-terminal pro-B-type natriuretic peptide predicts CVD events in men without clinical evidence of CHD, angina, or history of stroke, and appears related more strongly to the risk for fatal events. N-terminal pro-B-type natriuretic peptide also provides moderate risk discrimination, in excess of that provided by the measurement of C-reactive protein
Natural killer (NK) cell response to virus infections in mice with severe combined immunodeficiency. The stimulation of NK cells and the NK cell-dependent control of virus infections occur independently of T and B cell function
The activation, proliferation, and antiviral properties of natural killer (NK) cells were examined in severe combined immunodeficiency (SCID) mice to determine the influence of mature T or B cells on virus-induced NK cell functions and to more conclusively determine the antiviral properties of prototypical CD3- NK cells. NK cells were activated to high levels of cytotoxicity 3 d after infection of mice with lymphocytic choriomeningitis virus (LCMV) or murine cytomegalovirus (MCMV). Analyses of spleen leukocytes from LCMV-infected mice by a variety of techniques indicated that the NK cells proliferated and increased in number during infection. Propidium iodide staining of the DNA of cycling cells revealed that the great majority of proliferating spleen leukocytes 3 d after LCMV infection was of the NK cell phenotype (CD3-, Ig-, Mac-1+, CZ1+, 50% Thy-1+), in contrast to uninfected mice, whose proliferating cells were predominantly of other lineages. Analyses of the NK cell responses over a 2 wk period in control CB17 mice infected with MCMV indicated a sharp rise in serum interferon (IFN) and spleen NK cell activity early (days 3-5) in infection, followed by sharp declines at later stages. In SCID mice the IFN levels continued to rise over a 10-d period, whereas the NK cell response peaked on day 3-5 and gradually tapered. In contrast to the immunocompetent CB17 mice, SCID mice did not clear the MCMV infection and eventually succumbed. SCID mice, again in contrast to immunocompetent CB17 mice, also failed to clear infections with LCMV and Pichinde virus (PV); these mice, infected as adults, did not die but instead developed long-term persistent infections. Depletion of the NK cells in vivo with antiserum to asialo GM1 rendered both SCID and CB17 control mice much more sensitive to MCMV infection, as shown by titers of virus in organs and by survival curves. In contrast, similar depletions of NK cells did not enhance the titers of the NK cell-resistant virus, LCMV. Two variants of PV, one sensitive to NK cells and the other selected for resistance to NK cells by in vivo passage, were also tested in NK cell-depleted SCID mice. The NK-sensitive PV replicated to higher titers in NK cell-depleted SCID mice, whereas the titers of the NK cell-resistant PV were the same, whether or not the mice had NK cells. These experiments support the concept that CD3- prototypical NK cells mediate resistance to NK cell-sensitive viruses via a mechanism independent of antiviral or natural antibody.(ABSTRACT TRUNCATED AT 400 WORDS
On a Site of X-ray Emission in AE Aquarii
An analysis of recently reported results of XMM-Newton observations of AE Aqr
within a hypothesis that the detected X-ray source is located inside the Roche
lobe of the white dwarf is presented. I show this hypothesis to be inconsistent
with the currently adopted model of mass-transfer in the system. Possible
solutions of this problem are briefly discussed.Comment: 4 pages, accepted for publication in ApJ Letter
Vitamin D deficiency, impaired lung function and total and respiratory mortality in a cohort of older men: cross-sectional and prospective findings from The British Regional Heart Study
OBJECTIVES: itamin D deficiency is associated with chronic obstructive pulmonary disease (COPD). We examined the cross-sectional association between 25-hydroxyvitamin D (25(OH)D) and lung function impairment and assessed whether vitamin D deficiency is related to long-term mortality in those with impaired lung function. DESIGN: Prospective study. SETTING: General practices in the UK. PARTICIPANTS: 3575 men aged 60â79 years with no prevalent heart failure. OUTCOME MEASURES: Airway obstruction and mortality. The Global Initiative on Obstructive Lung diseases (GOLD) spirometry criteria was used to define airway obstruction. RESULTS: During the follow-up period of 20 years, there were 2327 deaths (114 COPD deaths). Vitamin D deficiency was defined as serum 25(OH)D levels20âng/mL. In cross-sectional analysis, vitamin D deficiency was more prevalent in those with moderate COPD (FEV/FVC 80%) or restrictive lung disease (FEV1/FVC >70%âand FVC =20âng/mL were 1.39 (1.10 to 1.75), 1.52 (1.17 to 1.98), 1.58 (1.17 to 2.14) and 1.39 (0.83 to 2.33) for those with no lung impairment, restrictive lung function, mild/moderate COPD and severe COPD, respectively. CONCLUSION: Men with COPD were more likely to be vitamin D deficient than those with normal lung function. Vitamin D deficiency is associated with increased all-cause mortality in older men with no lung impairment as well as in those with restrictive or obstructive lung impairment
Coexpression of the platelet-derived growth factor (PDGF) B chain and the PDGF beta receptor in isolated pancreatic islet cells stimulates DNA synthesis.
Hubble Space Telescope Observations of UV Oscillations in WZ Sagittae During the Decline from Outburst
We present a time series analysis of Hubble Space Telescope observations of
WZ Sge obtained in 2001 September, October, November and December as WZ Sge
declined from its 2001 July superoutburst. Previous analysis of these data
showed the temperature of the white dwarf decreased from ~29,000 K to ~18,000
K. In this study we binned the spectra over wavelength to yield ultraviolet
light curves at each epoch that were then analyzed for the presence of the
well-known 27.87 s and 28.96 s oscillations. We detect the 29 s periodicity at
all four epochs, but the 28 s periodicity is absent. The origin of these
oscillations has been debated since their discovery in the 1970s and competing
hypotheses are based on either white dwarf non-radial g-mode pulsations or
magnetically-channelled accretion onto a rotating white dwarf. By analogy with
the ZZ Ceti stars, we argue that the non-radial g-mode pulsation model demands
a strong dependence of pulse period on the white dwarf's temperature. However,
these observations show the 29 s oscillation is independent of the white
dwarf's temperature. Thus we reject the white dwarf non-radial g-mode pulsation
hypothesis as the sole origin of the oscillations. It remains unclear if
magnetically-funnelled accretion onto a rapidly rotating white dwarf (or belt
on the white dwarf) is responsible for producing the oscillations. We also
report the detection of a QPO with period ~18 s in the September light curve.
The amplitudes of the 29 s oscillation and the QPO vary erratically on short
timescales and are not correlated with the mean system brightness nor with each
other.Comment: 20 pages, 3 figures, 1 table; accepted for publication in Ap
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