Trapping electrons in electrostatic traps over the surface of helium

We have observed trapping of electrons in an electrostatic trap formed over the surface of liquid helium-4. These electrons are detected by a Single Electron Transistor located at the centre of the trap. We can trap any desired number of electrons between 1 and $\sim 30$. By repeatedly ($\sim 10^3-10^4$ times) putting a single electron into the trap and lowering the electrostatic barrier of the trap, we can measure the effective temperature of the electron and the time of its thermalisation after heating up by incoherent radiation.Comment: Presented at QFS06 - Kyoto, to be published in J. Low Temp. Phys., 6 pages, 3 figure

Wigner islands with electrons over helium

We present here the first experimental study of Wigner islands formed by electrons floating over helium. Electrons are trapped electrostatically in a mesoscopic structure covered with a helium film, behaving as a quantum dot. By removing electrons one by one, we are able to find the addition spectrum, i.e. the energy required to add (or extract) one electron from the trap with occupation number $N$. Experimental addition spectra are compared with Monte Carlo simulations for the actual trap geometry, confirming the ordered state of electrons over helium in the island.Comment: 12 pages, 13 figures, draft pape

Evidence for Single-Vortex Pinning and Unpinning Events in Superfluid 4He

We have observed two critical velocity levels for phase slips in superfluid 4He at temperatures between 14 and 44 mK, due to microparticles formed in the cell at low temperature. We interpret these observations as evidence for pinning and unpinning events of single vortices of nanometric size. From a study of the lifetime and unpinning velocities of the pinned vortices, we are led to conclude that unpinning takes place by quantum tunneling.Peer reviewe

Confidence intervals for performance estimates in 3D medical image segmentation

Medical segmentation models are evaluated empirically. As such an evaluation is based on a limited set of example images, it is unavoidably noisy. Beyond a mean performance measure, reporting confidence intervals is thus crucial. However, this is rarely done in medical image segmentation. The width of the confidence interval depends on the test set size and on the spread of the performance measure (its standard-deviation across of the test set). For classification, many test images are needed to avoid wide confidence intervals. Segmentation, however, has not been studied, and it differs by the amount of information brought by a given test image. In this paper, we study the typical confidence intervals in medical image segmentation. We carry experiments on 3D image segmentation using the standard nnU-net framework, two datasets from the Medical Decathlon challenge and two performance measures: the Dice accuracy and the Hausdorff distance. We show that the parametric confidence intervals are reasonable approximations of the bootstrap estimates for varying test set sizes and spread of the performance metric. Importantly, we show that the test size needed to achieve a given precision is often much lower than for classification tasks. Typically, a 1% wide confidence interval requires about 100-200 test samples when the spread is low (standard-deviation around 3%). More difficult segmentation tasks may lead to higher spreads and require over 1000 samples.Comment: 10 page

Detection of the Rotation of the Earth with a Superfluid Gyrometer

The effect of the rotation of the Earth, Ω⊕, on a superfluid resonator equipped with a 4.0 cm exp 2 rotation pickup loop and with a microaperture is reported. The velocity circulation induced in the loop by the rotation is detected by phase-slippage techniques. The magnitude of Ω⊕ is measured to better than 1%, and the north direction to ±0.5° for a 10 h observation time. This experiment is the superfluid counterpart of interferometric measurements based on the Sagnac effect.Peer reviewe

Search for supersolidity in 4He in low-frequency sound experiments

We present results of the search for supersolid 4He using low-frequency, low-level mechanical excitation of a solid sample grown and cooled at fixed volume. We have observed low frequency non-linear resonances that constitute anomalous features. These features, which appear below about 0.8 K, are absent in 3He. The frequency, the amplitude at which the nonlinearity sets in, and the upper temperature limit of existence of these resonances depend markedly on the sample history.Comment: Submitted to the Quantum Fluids and Solids Conf. Aug. 2006 Kyot

Nasal cavity lobular capillary hemangioma due to insect sting

SummaryIntroductionLobular capillary hemangioma is a frequent benign vascular inflammatory lesion of the skin tissue. It rarely reaches the mucous membrane, and the nasal fossa involvement is exceptional.Case reportA 68-year-old woman presented with an ulcerous hemorrhagic mass blocking the left nasal fossa, which had appeared a few weeks after a wasp sting in the nose. The insect was evacuated only three weeks after the sting. The clinical and radiological data suggested malignancy. Biopsy under local anesthesia proved non-contributory and was complicated by 1 week's hospitalization for severe nosebleed. Surgical excision under video-endoscopy confirmed diagnosis. At 31 months’ follow-up, the patient was free of recurrence.Discussion/conclusionThe pathogeny of lobular capillary hemangioma is uncertain. No previous cases affecting the mucous membrane after insect sting have been reported. Except in the typical contexts of long-term packing or pregnancy, diagnosis can be difficult and misleading. It can mimic a malignant pathology. Its rich vascularization requires caution during biopsy, and the risk of recurrence requires excision to be complete

The Frequency Dependence of Critical-velocity Behavior in Oscillatory Flow of Superfluid Helium-4 Through a 2-micrometer by 2-micrometer Aperture in a Thin Foil

The critical-velocity behavior of oscillatory superfluid Helium-4 flow through a 2-micrometer by 2-micrometer aperture in a 0.1-micrometer-thick foil has been studied from 0.36 K to 2.10 K at frequencies from less than 50 Hz up to above 1880 Hz. The pressure remained less than 0.5 bar. In early runs during which the frequency remained below 400 Hz, the critical velocity was a nearly-linearly decreasing function of increasing temperature throughout the region of temperature studied. In runs at the lowest frequencies, isolated 2 Pi phase slips could be observed at the onset of dissipation. In runs with frequencies higher than 400 Hz, downward curvature was observed in the decrease of critical velocity with increasing temperature. In addition, above 500 Hz an alteration in supercritical behavior was seen at the lower temperatures, involving the appearance of large energy-loss events. These irregular events typically lasted a few tens of half-cycles of oscillation and could involve hundreds of times more energy loss than would have occurred in a single complete 2 Pi phase slip at maximum flow. The temperatures at which this altered behavior was observed rose with frequency, from ~ 0.6 K and below, at 500 Hz, to ~ 1.0 K and below, at 1880 Hz.Comment: 35 pages, 13 figures, prequel to cond-mat/050203

Gene regulation in parthenocarpic tomato fruit

Parthenocarpy is potentially a desirable trait for many commercially grown fruits if undesirable changes to structure, flavour, or nutrition can be avoided. Parthenocarpic transgenic tomato plants (cv MicroTom) were obtained by the regulation of genes for auxin synthesis (iaaM) or responsiveness (rolB) driven by DefH9 or the INNER NO OUTER (INO) promoter from Arabidopsis thaliana. Fruits at a breaker stage were analysed at a transcriptomic and metabolomic level using microarrays, real-time reverse transcription-polymerase chain reaction (RT-PCR) and a Pegasus III TOF (time of flight) mass spectrometer. Although differences were observed in the shape of fully ripe fruits, no clear correlation could be made between the number of seeds, transgene, and fruit size. Expression of auxin synthesis or responsiveness genes by both of these promoters produced seedless parthenocarpic fruits. Eighty-three percent of the genes measured showed no significant differences in expression due to parthenocarpy. The remaining 17% with significant variation (P <0.05) (1748 genes) were studied by assigning a predicted function (when known) based on BLAST to the TAIR database. Among them several genes belong to cell wall, hormone metabolism and response (auxin in particular), and metabolism of sugars and lipids. Up-regulation of lipid transfer proteins and differential expression of several indole-3-acetic acid (IAA)- and ethylene-associated genes were observed in transgenic parthenocarpic fruits. Despite differences in several fatty acids, amino acids, and other metabolites, the fundamental metabolic profile remains unchanged. This work showed that parthenocarpy with ovule-specific alteration of auxin synthesis or response driven by the INO promoter could be effectively applied where such changes are commercially desirable

Platelet Serotonin Level Predicts Survival in Amyotrophic Lateral Sclerosis

International audienceBACKGROUND: Amyotrophic lateral sclerosis (ALS) is a life-threatening neurodegenerative disease involving upper and lower motor neurons loss. Clinical features are highly variable among patients and there are currently few known disease-modifying factors underlying this heterogeneity. Serotonin is involved in a range of functions altered in ALS, including motor neuron excitability and energy metabolism. However, whether serotoninergic activity represents a disease modifier of ALS natural history remains unknown. METHODOLOGY: Platelet and plasma unconjugated concentrations of serotonin and plasma 5-HIAA, the major serotonin metabolite, levels were measured using HPLC with coulometric detection in a cohort of 85 patients with ALS all followed-up until death and compared to a control group of 29 subjects. PRINCIPAL FINDINGS: Platelet serotonin levels were significantly decreased in ALS patients. Platelet serotonin levels did not correlate with disease duration but were positively correlated with survival of the patients. Univariate Cox model analysis showed a 57% decreased risk of death for patients with platelet serotonin levels in the normal range relative to patients with abnormally low platelet serotonin (p = 0.0195). This protective effect remained significant after adjustment with age, gender or site of onset in multivariate analysis. Plasma unconjugated serotonin and 5-HIAA levels were unchanged in ALS patients compared to controls and did not correlate with clinical parameters. CONCLUSIONS/SIGNIFICANCE: The positive correlation between platelet serotonin levels and survival strongly suggests that serotonin influences the course of ALS disease