Compressive Sensing DNA Microarrays

Compressive sensing microarrays (CSMs) are DNA-based sensors that operate using group testing and compressive sensing (CS) principles. In contrast to conventional DNA microarrays, in which each genetic sensor is designed to respond to a single target, in a CSM, each sensor responds to a set of targets. We study the problem of designing CSMs that simultaneously account for both the constraints from CS theory and the biochemistry of probe-target DNA hybridization. An appropriate cross-hybridization model is proposed for CSMs, and several methods are developed for probe design and CS signal recovery based on the new model. Lab experiments suggest that in order to achieve accurate hybridization profiling, consensus probe sequences are required to have sequence homology of at least 80% with all targets to be detected. Furthermore, out-of-equilibrium datasets are usually as accurate as those obtained from equilibrium conditions. Consequently, one can use CSMs in applications in which only short hybridization times are allowed

Adherence to highly active antiretroviral therapy in depressed patients with HIV/AIDS attending a Nigerian university teaching hospital clinic

Objective:  Key words:  Medication adherence; Depressive disorder; Highly Active Antiretroviral Therapy; HIV infectionTo determine the prevalence of depressive disorder in patients with HIV/AIDS receiving HAART; to determine the effect of depressive disorder on adherence to antiretroviral therapy; and to determine the significance of the association. Method: The study was conducted amongst outpatients of Ahmadu Bello University Teaching Hospital, Zaria. A sociodemographic and drug adherence questionnaire was administered. The Centre for Epidemiological Studies Depression Scale (CES-D) was used to screen for depressive symptoms while the Schedule for Clinical Assessment in Neuropsychiatry (SCAN) was used to confirm the diagnosis of depressive disorder. Results: A total of 310 patients with HIV/AIDS receiving HAART participated in the study. 68.4% were female and the mean age was 35.5 (± 8.97 years). 37.4% had secondary education, while 27.1% had tertiary education. Sixty-six participants (21.3%) had significant depressive symptoms while 14.2% met ICD-10 diagnostic criteria for depressive disorder. Overall, 73% of participants had good adherence to HAART. 63.6% of participants with depressive disorder had poor adherence to HAART compared to 21.1% of participants without depressive disorder (

Alcohol-Related Problems And High Risk Sexual Behaviour In Patients With Hiv/Aids Attending Medical Clinic In A Nigerian University Teaching Hospital

This study was designed to determine the rate of alcohol related-problems in patients with HIV/ AIDS and its association with high risk sexual behavior. A consecutive sample of 120 patients with HIV/AIDS attending the Medical Out-patient Department (M.O.P.D) in Ahmadu Bello University Teaching Hospital (A.B.U.T.H), Zaria was assessed. All participants were screened for alcohol related problems using the Alcohol Use Disorder Identification Test (AUDIT). High risk sexual behavior was assessed using the HIV Risk-taking Behavior Questionnaire (HRBQ). Alcohol-related problems were found in 28.3% of participants (10% had hazardous use, 3.3% had harmful use and 15% had alcohol dependence). There was a significant association between alcohol-related problems and risky sexual behavior. Alcohol-related problems are fairly common in people already infected with HIV/AIDS and are associated with high-risk sexual behavior. Thus, screening and treatment should be part of an effective HIV intervention program. Key Words: Alcohol related problems, high-risk sexual behavior, hazardous use, harmful use, alcohol dependenc

This is what COPD looks like

Despite decades of research, and the growing healthcare and societal burden of chronic obstructive pulmonary disease (COPD), therapeutic COPD breakthroughs have not occurred. Sub-optimal COPD patient phenotyping, an incomplete understanding of COPD pathogenesis and a scarcity of sensitive tools that provide patient-relevant intermediate endpoints likely all play a role in the lack of new, efficacious COPD interventions. In other words, COPD patients are still diagnosed based on the presence of persistent airflow limitation measured using spirometry. Spirometry measurements reflect the global sum of all the different possible COPD pathologies and perhaps because of this, we lose sight of the different contributions of airway and parenchymal abnormalities. With recent advances in thoracic X-ray computed tomography (CT) and magnetic resonance imaging (MRI), lung structure and function abnormalities may be regionally identified and measured. These imaging endpoints may serve as biomarkers of COPD that can be used to better phenotype patients. Therefore, here we review novel CT and MRI measurements that help reveal COPD phenotypes and what COPD really \u27looks\u27 like, beyond spirometric indices. We discuss MR and CT imaging approaches for generating reproducible and sensitive measurements of COPD phenotypes related to pulmonary ventilation and perfusion as well as airway and parenchyma anatomical and morphological features. These measurements may provide a way to advance the development and testing of new COPD interventions and therapies

RSSI Based Indoor Localization for Smartphone Using Fixed and Mobile Wireless Node

Nowadays with the dispersion of wireless networks, smartphones and diverse related services, different localization techniques have been developed. Global Positioning System (GPS) has a high rate of accuracy for outdoor localization but the signal is not available inside of buildings. Also other existing methods for indoor localization have low accuracy. In addition, they use fixed infrastructure support. In this paper, we present a novel system for indoor localization, which also works well outside. We have developed a mathematical model for estimating location (distance and direction) of a mobile device using wireless technology. Our experimental results on Smartphones (Android and iOS) show good accuracy (an error less than 2.5 meters). We have also used our developed system in asset tracking and complex activity recognition

A Novel Real-Time Non-invasive Hemoglobin Level Detection Using Video Images from Smartphone Camera

Hemoglobin level detection is necessary for evaluating health condition in the human. In the laboratory setting, it is detected by shining light through a small volume of blood and using a colorimetric electronic particle counting algorithm. This invasive process requires time, blood specimens, laboratory equipment, and facilities. There are also many studies on non-invasive hemoglobin level detection. Existing solutions are expensive and require buying additional devices. In this paper, we present a smartphone-based non-invasive hemoglobin detection method. It uses the video images collected from the fingertip of a person. We hypothesized that there is a significant relation between the fingertip mini-video images and the hemoglobin level by laboratory gold standard. We also discussed other non-invasive methods and compared with our model. Finally, we described our findings and discussed future works

Discriminative Region Proposal Adversarial Networks for High-Quality Image-to-Image Translation

Image-to-image translation has been made much progress with embracing Generative Adversarial Networks (GANs). However, it's still very challenging for translation tasks that require high quality, especially at high-resolution and photorealism. In this paper, we present Discriminative Region Proposal Adversarial Networks (DRPAN) for high-quality image-to-image translation. We decompose the procedure of image-to-image translation task into three iterated steps, first is to generate an image with global structure but some local artifacts (via GAN), second is using our DRPnet to propose the most fake region from the generated image, and third is to implement "image inpainting" on the most fake region for more realistic result through a reviser, so that the system (DRPAN) can be gradually optimized to synthesize images with more attention on the most artifact local part. Experiments on a variety of image-to-image translation tasks and datasets validate that our method outperforms state-of-the-arts for producing high-quality translation results in terms of both human perceptual studies and automatic quantitative measures.Comment: ECCV 201

R&D Uncertainty in Future Benefits

This paper contributes to the current debate on accounting treatment of R&D expenditures. We considered two different measures of future benefits to a firm, sales revenue and operating cash flows. We provide evidence that R&D expenditures do not generate more uncertain future sales revenue or operating cash flows compared to capital expenditures. In terms of sales revenue, R&D expenditures generate significantly less uncertain future benefits compared to capital expenditures. And in terms of operating cash flows, our results do not provide conclusive evidence that whether R&D expenditures generate more uncertain future benefits than capital expenditures or not

Design and Analysis of a Novel Lightweight Translator Permanent Magnet Linear Generator for Oceanic Wave Energy Conversion

© 1965-2012 IEEE. At present, most of the linear generators contain a heavy translator for converting wave power from the ocean into electrical power. As the translator is connected to the buoy, the buoy dynamic performance is reduced by the large mass and, as a result, low velocity of the translator would degrade the electricity generation of the linear generator. This problem has been minimized by the new design in this paper, where the translator is clipped off at first and split into two separate portions to minimize its weight. The secondary stator is magnetically coupled with a special m-shaped main stator which is used to flow the necessary magnetic flux. The weight of the proposed translator is 21.82% lower than that of conventional one and 49.1% by using a recently available permanent magnet with higher specifications. The finite-element method is applied in ANSYS simulation environment for the analysis and comparison between the proposed and conventional designs. Different parameters of the conventional and the proposed linear generator have been discussed in this paper. The simulation results show that the proposed design can generate the same amount of electricity as the existing one with almost half of the translator size. According to the mathematical model, it is understood that the dynamics of the translator would be higher for its lower mass and vice versa. Therefore, minimizing the translator size would result in decrease of mass, which increases the dynamics of the buoy connected to the translator

Cu(II) biosorption by living biofilms:Isothermal, chemical, physical and biological evaluation

Dissolved copper in stormwater runoff is a significant environmental problem. Biosorption of dissolved metals using microorganisms is known as a green, low-cost and efficient method. However, the role of live biological agents in the remediation of dissolved copper in Sustainable Drainage (SuDS) has not been reported. In this study, the effect of pH, initial concentration and temperature, on bacteria in different stages of biofilm development on a geotextile, along with Cu(II) removal efficiencies, were evaluated. Maximum Cu(II) removal efficiency (92%) was observed at pH 6. By decreasing the pH from 6 to 2, a log 5 reduction in bacteria was observed and Carboxyl groups transformed from -COO- to –COOH. The maximum biosorption capacity (119 mg g−1) was detected on day 1 of biofilm development, however, maximum removal efficiency (97%) was measured on day 21 of biofilm incubation. Extracellular Polymeric Substance (EPS) showed a better protection of CFUs in more mature biofilms (day 21) with less than 0.1 log decrease when exposed to 200 mL−1 Cu(II), whereas, biofilm on day 1 of incubation showed a 2 log reduction in CFUs number. Thermodynamic studies showed that the maximum Cu(II) biosorption capacity of biofilms, incubated for 7 days (117 mg g−1) occurred at 35 °C. Thermodynamic and kinetic modelling of data revealed that a physical, feasible, spontaneous and exothermic process controlled the biosorption, with a diffusion process observed in external layers of the biofilm, fitting a pseudo-second order model. Equilibrium data modelling and high R2 values of Langmuir model indicated that the biosorption took place by a monolayer on the living biofilm surface in all stages of biofilm development