13 research outputs found
Genome-wide transcriptome analysis of hypothalamus in rats with inherited stress-induced arterial hypertension
Metabotropic Glutamate Receptor–Dopamine Interactions in the Basal Ganglia Motor Circuit
Opposite Effects of mGluR1a and mGluR5 Activation on Nucleus Accumbens Medium Spiny Neuron Dendritic Spine Density
Possible involvement of neuronal nicotinic acetylcholine receptors in compensatory brain mechanisms at early stages of Parkinson’s disease
Group II metabotropic glutamate receptors modify N-methyl-D-aspartate receptors via Src kinase
Striatal metabotropic glutamate receptors as a target for pharmacotherapy in Parkinson’s disease
Metabotropic glutamate receptors in the basal ganglia motor circuit
In recent years there have been tremendous advances in our understanding of the circuitry of the basal ganglia and our ability to predict the behavioural effects of specific cellular changes in this circuit on voluntary movement. These advances, combined with a new understanding of the rich distribution and diverse physiological roles of metabotropic glutamate receptors in the basal ganglia, indicate that these receptors might have a key role in motor control and raise the exciting possibility that they might provide therapeutic targets for the treatment of Parkinson's disease and related disorders