VALGANCICLOVIR INDUCED THROMBOCYTOPENIA: A CASE REPORT

Triple immunosuppression is very pivotal in maintaining the graft in case of renal transplantation. But because of severe immunosuppression, always there is chance of severe adverse effects. Hematological toxicity is usually very common but dreaded in case of renal transplant patients. Here, we report a case of valganciclovir-induced drop in platelet counts in a postrenal transplant patient

TACROLIMUS INDUCED TREMORS AMONG POST RENAL TRANSPLANT PATIENTS: A CASE SERIES

Triple immunosuppression in renal transplant has drastically changed the outcome of graft survival. However, concern always remains among thephysicians because of adverse effects produced due to triple immunosuppression. Calcineurin inhibitors are associated with wide range of side effects. Hence, we report a case series of tremors associated with tacrolimus among renal transplant patients in a tertiary care hospital in southern India.Â

A CASE REPORT OF NADROPARIN INDUCED HYPERKALEMIA

ABSTRACTNadroparin, a low molecular weight heparin, has prophylactic and therapeutic use in thromboembolic disorder. In a patient with carcinoma ovarystage 3 B, nadroparin was given prophylactically for deep vein thrombosis (DVT) before and after interval cytoreduction surgery. Nadroparin 0.3 mlwas given subcutaneously once daily for 1 day preoperatively and 8 days postoperatively. Rise in serum potassium was observed on the third postoperativedaysuggestiveof hyperkalemia.Intravenousfluids weregiven,and thedrug wasstoppedon the 9 post-operative day and hyperkalemiaresolved after 2 days. Monitoring of serum potassium level is essential when Nadroparin is administered prophylactically for more than 7 days forDVT. As this case illustrates a causal relationship between nadroparin and hyperkalemia, caution must be exercised with nadroparin.Keywords: Nadroparin, Hyperkalemia, Thrombosis.t

Rabeprazole induced Fixed Drug Eruption: A rare case report

Among cutaneous adverse drug reactions, fixed drug eruption is the most common cutaneous drug reaction among the Indian population. The drugsmost commonly implicated in fixed drug eruption are analgesics and antibiotics. Here, we report a case of fixed drug reaction caused by rabeprazole.  Â

ACECLOFENAC-INDUCED STEVENS-JOHNSON SYNDROME AFTER ONE SINGLE DOSE: A MAIDEN CASE REPORT

Drugs are known to cause various adverse drug reactions involving major organ systems. Skin-related adverse reactions are very common and range from a simple rash to life-threatening condition like Stevens-Johnson syndrome. Various drugs are known to cause skin reactions which include antiepileptics, analgesics, antibiotics, and proton-pump inhibitors. Nonsteroidal anti-inflammatory drugs causing life-threatening conditions such as Stevens-Johnson syndrome and toxic epidermal necrolysis are very rare and only few case reports are published. Hence, we report a case of Aceclofenac-induced Stevens-Johnson syndrome after single time administration in a tertiary care hospital in India

SORAFENIB INDUCED ACNEIFORM ERUPTIONS: A CASE REPORT

ABSTRACTSorafenib an oral tyrosine kinase inhibitor is used in the treatment of hepatocellular carcinoma, renal cell carcinoma and thyroid cancer. Sorafenib acts by inhibiting various kinases like tyrosine kinase, RET tyrosine kinase, endothelial growth factor receptor, vascular endothelial growth factor 2 and 3 inhibits angiogenesis and cell proliferation. Acneiform eruptions are known side effect of EGFR inhibitors with incidence ranging between 20 to 90 percent [3], but acneiform eruptions with Sorafenib is seldom seen. Hence, we report a case of Sorafenib induced acneiform eruptions.Keywords: Sorafenib, EGFR, acneiform eruptions, adverse drug reaction

Naked Singularities as Particle Accelerators II

We generalize here our earlier results on particle acceleration by naked singularities. We showed recently[1] that the naked singularities that form due to gravitational collapse of massive stars provide a suitable environment where particles could get accelerated and collide at arbitrarily high center of mass energies. However, we focussed there only on the spherically symmetric gravitational collapse models, which were also assumed to be self-similar. In this paper, we broaden and generalize the result to all gravitational collapse models leading to the formation of a naked singularity as final state of collapse, evolving from a regular initial data, without making any prior restrictive assumptions about the spacetime symmetries such as above. We show that when the particles interact and collide near the Cauchy horizon, the energy of collision in the center of mass frame will be arbitrarily high, thus offering a window to the Planck scale physics. We also consider the issue of various possible physical mechanisms of generation of such very high energy particles from the vicinity of naked singularity. We then construct a model of gravitational collapse to a timelike naked singularity to demonstrate the working of these ideas, where the pressure is allowed to be negative but the energy conditions are respected. We show that a finite amount of mass-energy density has to be necessarily radiated away from the vicinity of the naked singularity as the collapse evolves. Therefore the nature of naked singularities, both at classical and quantum level could play an important role in the process of particle acceleration, explaining the occurrence of highly energetic outgoing particles in the vicinity of Cauchy horizon that participate in extreme high energy collisions.Comment: 13 pages, 5 figures, Accepted for publication in Phys. Rev. D, Reference and Acknowledgments adde

On the Transfer of Metric Fluctuations when Extra Dimensions Bounce or Stabilize

In this report, we study within the context of general relativity with one extra dimension compactified either on a circle or an orbifold, how radion fluctuations interact with metric fluctuations in the three non-compact directions. The background is non-singular and can either describe an extra dimension on its way to stabilization, or immediately before and after a series of non-singular bounces. We find that the metric fluctuations transfer undisturbed through the bounces or through the transients of the pre-stabilization epoch. Our background is obtained by considering the effects of a gas of massless string modes in the context of a consistent 'massless background' (or low energy effective theory) limit of string theory. We discuss applications to various approaches to early universe cosmology, including the ekpyrotic/cyclic universe scenario and string gas cosmology.Comment: V2. Minor Clarifications V3. appendix and 2 figures added, typos corrected, conclusions unchanged 12 pages, 6 figure

Note to Coin Exchanger Using PLC

Now days, coins are required at lot of places and we have to suffer a lot for the change in various public places in daily life. Coins are used more instead of note in various places like bus station, railway station, malls, parks, even in rural areas where nowadays also coin telephone system is used. For such applications coins are used extremely, so we thought to develop an exchanger machine which will give us coins instead of notes. As there are lots of techniques to detect the Indian currency note, these are texture based, pattern based, checking by the watermarking, checking the micro lettering, color based recognition technique. The most preferable technique along all these is color based recognition. It is constructed by counting the number of pixels of each color. Color sensor is used which senses the RGB (Red, Green, Blue) colors and the result is given to the controller which will manipulate the coin container through relays and motors, the user simply press the keypad for which type of change he wants whether one rupee coins or five rupee or mixed and hence in the output we get coins as user requirement

AUGMENTIN INDUCED THROMBOCYTOSIS: A MAIDEN CASE SERIES

When an infected patient suffers from thrombocytosis, it is very difficult to identify beta-lactam antibiotic induced cases of the disease and separate those from the possibility that thrombocytosis is an acute-phase reaction in the infected patient. We present 3 cases who were treated with Augmentin for various indications and developed thrombocytosis during the treatment course. The Naranjo probability scale indicates Augmentin as the possible cause of the thrombocytosis in all our patients.  Â