Biomonitoring of bisphenol A concentrations in maternal and umbilical cord blood in regard to birth outcomes and adipokine expression: a birth cohort study in Taiwan

<p>Abstract</p> <p>Background</p> <p>Bisphenol A (BPA) is a sealant and flux of plastic materials and has been determined to be an endocrine-disrupting chemical. Prenatal exposure to BPA can lead to substantial adverse effects on fetal growth and development. This study was conducted to assess BPA concentration in pregnant women and umbilical cord blood, and to investigate whether maternal BPA exposure affected fetal outcomes including lower birth weight (LBW), smaller size for gestational age (SGA), and high leptin (HLP) and low adiponectin (LAD) secretion.</p> <p>Methods</p> <p>We measured the BPA levels of maternal blood (n = 97) and umbilical cord blood (n = 97) with a high-performance liquid chromatography/UV detector. The protein secretion of leptin and adiponectin were separately determined using enzyme-linked immunosorbent assay. A logistic regression was performed to estimate the effects of maternal exposure to BPA on LBW, SGA, and adverse action of adipokines in newborns.</p> <p>Results</p> <p>The geometric means of BPA concentration in maternal blood and fetal cord blood were 2.5 ng/ml and 0.5 ng/ml, respectively. Elevated risks of LBW (OR 2.42, 95% confidence interval (CI) 1.72-3.36), SGA (OR 2.01, 95% CI 1.39-3.01), and adverse action of leptin (OR 1.67, 95% CI 1.12-2.25) and adiponectin (OR 1.25, 95% CI 1.52-3.97) were observed in male neonates in the highest quartile of maternal BPA exposure.</p> <p>Conclusions</p> <p>Elevated prenatal BPA exposure increased the risk of LBW, SGA, and adverse actions of adipokines in neonates, especially in male infants. These results provide further evidence that maternal exposure is correlated with adverse birth outcomes.</p

Cost-efficient nearly zero-energy buildings (NZEBs)

The next level of energy performance of new buildings within the European Union will be the Nearly Zero-Energy Building (NZEB). A lot of work has been spent on pilot and demonstration buildings on this and even higher energy performance levels throughout many EU countries. However, most of the high performance buildings realised so far result in additional investment costs when compared to the current national minimum energy performance requirements. The considerably higher investment costs are one of the main barriers to the early application of the NZEB-level in Europe. The EU Horizon 2020 project CoNZEBs works on technical solution sets that result in lower investment costs for NZEBs, bringing the costs close to those of conventional new buildings. The project focus is on multi-family houses. In each of the four participant countries Germany, Denmark, Italy and Slovenia a team of researchers is analysing which sets of market-ready technologies at the building envelope, the services systems for heating, domestic hot water, ventilation and cooling (where required) in combination with renewable energy systems can fulfil the NZEB requirements at lower costs than those incurred by the national mainstream NZEB application. Additional efforts are being spent on the life-cycle costs and the life-cycle analysis of the solution sets, as well as on the impact of future developments of primary energy factors, energy costs and technology efficiencies. Since details of the CoNZEBs work are presented in several additional papers, this document gives an overview of the different tasks and results that are available so far