Partition Function for (2+1)-Dimensional Einstein Gravity

Taking (2+1)-dimensional pure Einstein gravity for arbitrary genus $g$ as a model, we investigate the relation between the partition function formally defined on the entire phase space and the one written in terms of the reduced phase space. In particular the case of $g=1$ is analyzed in detail. By a suitable gauge-fixing, the partition function $Z$ basically reduces to the partition function defined for the reduced system, whose dynamical variables are $(\tau^A, p_A)$. [The $\tau^A$'s are the Teichm\"uller parameters, and the $p_A$'s are their conjugate momenta.] As for the case of $g=1$, we find out that $Z$ is also related with another reduced form, whose dynamical variables are $(\tau^A, p_A)$ and $(V, \sigma)$. [Here $\sigma$ is a conjugate momentum to 2-volume $V$.] A nontrivial factor appears in the measure in terms of this type of reduced form. The factor turns out to be a Faddeev-Popov determinant coming from the time-reparameterization invariance inherent in this type of formulation. Thus the relation between two reduced forms becomes transparent even in the context of quantum theory. Furthermore for $g=1$, a factor coming from the zero-modes of a differential operator $P_1$ can appear in the path-integral measure in the reduced representation of $Z$. It depends on the path-integral domain for the shift vector in $Z$: If it is defined to include $\ker P_1$, the nontrivial factor does not appear. On the other hand, if the integral domain is defined to exclude $\ker P_1$, the factor appears in the measure. This factor can depend on the dynamical variables, typically as a function of $V$, and can influence the semiclassical dynamics of the (2+1)-dimensional spacetime. These results shall be significant from the viewpoint of quantum gravity.Comment: 21 pages. To appear in Physical Review D. The discussion on the path-integral domain for the shift vector has been adde

Classical and quantum wormholes in a flat Λ\Lambda-decaying cosmology

We study the classical and quantum wormholes for a flat {\it Euclidean} Friedmann-Robertson-Walker metric with a perfect fluid including an ordinary matter source plus a source playing the role of dark energy (decaying cosmological term). It is shown that classical wormholes exist for this model and the quantum version of such wormholes are consistent with the Hawking-Page conjecture for quantum wormholes as solutions of the Wheeler-DeWitt equation.Comment: 8 pages, 4 figures, accepted for publication in IJT

Poincar\'{e} gauge theory of gravity

A Poincar\'{e} gauge theory of (2+1)-dimensional gravity is developed. Fundamental gravitational field variables are dreibein fields and Lorentz gauge potentials, and the theory is underlain with the Riemann-Cartan space-time. The most general gravitational Lagrangian density, which is at most quadratic in curvature and torsion tensors and invariant under local Lorentz transformations and under general coordinate transformations, is given. Gravitational field equations are studied in detail, and solutions of the equations for weak gravitational fields are examined for the case with a static, \lq \lq spin"less point like source. We find, among other things, the following: (1)Solutions of the vacuum Einstein equation satisfy gravitational field equations in the vacuum in this theory. (2)For a class of the parameters in the gravitational Lagrangian density, the torsion is \lq \lq frozen" at the place where \lq \lq spin" density of the source field is not vanishing. In this case, the field equation actually agrees with the Einstein equation, when the source field is \lq \lq spin"less. (3)A teleparallel theory developed in a previous paper is \lq \lq included as a solution" in a limiting case. (4)A Newtonian limit is obtainable, if the parameters in the Lagrangian density satisfy certain conditions.Comment: 27pages, RevTeX, OCU-PHYS-15

Microphysical Approach to Nonequilibrium Dynamics of Quantum Fields

We examine the nonequilibrium dynamics of a self-interacting $\lambda\phi^4$ scalar field theory. Using a real time formulation of finite temperature field theory we derive, up to two loops and $O(\lambda^2)$, the effective equation of motion describing the approach to equilibrium. We present a detailed analysis of the approximations used in order to obtain a Langevin-like equation of motion, in which the noise and dissipation terms associated with quantum fluctuations obey a fluctuation-dissipation relation. We show that, in general, the noise is colored (time-dependent) and multiplicative (couples nonlinearly to the field), even though it is still Gaussian distributed. The noise becomes white in the infinite temperature limit. We also address the effect of couplings to other fields, which we assume play the r\^ole of the thermal bath, in the effective equation of motion for $\phi$. In particular, we obtain the fluctuation and noise terms due to a quadratic coupling to another scalar field.Comment: 30 pages, LaTex (uses RevTex 3.0), DART-HEP-93/0

Negative modes in the four-dimensional stringy wormholes

We study the Giddings-Strominger wormholes in string theories. We found negative modes among O(4)-symmetric fluctuations about the non-singular wormhole background. Hence the stringy wormhole contribution to the euclidean functional integral is purely imaginary. This means that the stringy wormhole is a bounce (not an instanton) and describes the nucleation and growth of wormholes in the Minkowski spacetime.Comment: 12 pages 2 figures, RevTe

Field-enlarging transformations and chiral theories

A field-enlarging transformation in the chiral electrodynamics is performed. This introduces an additional gauge symmetry to the model that is unitary and anomaly-free and allows for comparison of different models discussed in the literature. The problem of superfluous degrees of freedom and their influence on quantization is discussed. Several "mysteries" are explained from this point of view.Comment: 14 pages, LaTeX-file, BI-TP 93/0

Therapeutics potentiating microglial p21-Nrf2 axis can rescue neurodegeneration caused by neuroinflammation

神経炎症の抑制を可能にする新規化合物を発⾒ --iPS-ドパミン神経前駆細胞の移植を促進--. 京都大学プレスリリース. 2020-11-16.Neurodegenerative disorders are caused by progressive neuronal loss, and there is no complete treatment available yet. Neuroinflammation is a common feature across neurodegenerative disorders and implicated in the progression of neurodegeneration. Dysregulated activation of microglia causes neuroinflammation and has been highlighted as a treatment target in therapeutic strategies. Here, we identified novel therapeutic candidate ALGERNON2 (altered generation of neurons 2) and demonstrate that ALGERNON2 suppressed the production of proinflammatory cytokines and rescued neurodegeneration in a 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)–induced Parkinson’s disease model. ALGERNON2 stabilized cyclinD1/p21 complex, leading to up-regulation of nuclear factor erythroid 2–related factor 2 (Nrf2), which contributes to antioxidative and anti-inflammatory responses. Notably, ALGERNON2 enhanced neuronal survival in other neuroinflammatory conditions such as the transplantation of induced pluripotent stem cell–derived dopaminergic neurons into murine brains. In conclusion, we present that the microglial potentiation of the p21-Nrf2 pathway can contribute to neuronal survival and provide novel therapeutic potential for neuroinflammation-triggered neurodegeneration

Viscosities of Quark-Gluon Plasmas

The quark and gluon viscosities are calculated in quark-gluon plasmas to leading orders in the coupling constant by including screening. For weakly interaction QCD and QED plasmas dynamical screening of transverse interactions and Debye screening of longitudinal interactions controls the infrared divergences. For strongly interacting plasmas other screening mechanisms taken from lattice calculations are employed. By solving the Boltzmann equation for quarks and gluons including screening the viscosity is calculated to leading orders in the coupling constant. The leading logarithmic order is calculated exactly by a full variational treatment. The next to leading orders are found to be very important for sizable coupling constants as those relevant for the transport properties relevant for quark-gluon plasmas created in relativistic heavy ion collisions and the early universe.Comment: 12 pages + 6 figures, report LBL-3492