Phosphorus availability determines the response of tundra ecosystem carbon stocks to nitrogen enrichment.

This study was funded by NERC (NE/I016899/1) and facilitated by use of NERC facilities at Harland Huset, Ny-Ålesund and the kind support of Nick Cox and colleagues. Nancy Burns assisted with field sampling and Brodie Shaw and Rob Mills assisted with laboratory analyses. Open access via Springer Compact Agreement.Peer reviewedPublisher PD

Cognitive Impairment in Multiple Sclerosis: Clinical Manifestation, Neuroimaging Correlates, and Treatment

Cognitive impairment is found in up to 70% of patients with multiple sclerosis (MS). Once thought of as a variant of subcortical dementia with a characteristic set of deficits, we now know that MS-related cognitive impairment can have many faces. This conceptual change in neuropsychology is embedded in a paradigm shift in the neuroscientific understanding of MS over the past 25 years: Partly based on modern neuroimaging techniques, the classical view of MS as an inflammatory demyelinating disease affecting the white matter of the central nervous system has been extended. In particular, many studies have shown that the MS pathology also includes neurodegeneration, and that gray matter structures such as the cerebral cortex can also show focal lesions, atrophy, or both. The authors present an updated summary of the clinical manifestation and neuroimaging correlates of cognitive impairment in MS, and discuss the relatively few treatment options available to date

The relevance of cortical lesions in patients with multiple sclerosis

BACKGROUND: Recent studies suggest that cortical lesions in multiple sclerosis (MS) substantially contribute to clinical disease severity. The present study aimed at investigating clinical, neuroanatomical, and cognitive correlates of these cortical lesions with a novel approach, i.e. by comparing two samples of relapsing-remitting multiple sclerosis (RRMS) patients, one group with and the other without cortical lesions. METHODS: High-resolution structural MRI was acquired from 42 RRMS patients and 43 controls (HC). The patient group was dichotomized based on the presence versus absence of DIR-hyperintense cortex-involving lesions, resulting in a cortical lesion group (CL, n = 32) and a non-cortical lesion group (nCL, n =10). Cognitive functioning was assessed in all participants with a comprehensive neuropsychological battery, covering mnestic, executive, and attentional functions. RESULTS: Highest densities of cortical lesions in the CL group were observed in the bilateral parahippocampal gyrus. Relative to HC, patients with cortical lesions - but not those without - showed significant global cortical thinning and mnestic deficits. The two patient groups did not differ from each other regarding demographic and basic disease characteristics such as EDSS scores. CONCLUSION: The appearance of cortical lesions in MS patients is associated with cortical thinning as well as mnestic deficits, which might be key characteristics of a 'cortically dominant' MS subtype

The Effects of Manipulation of Visual Feedback in Virtual Reality on Cortical Activity

It is known that systematic visual distortions using virtual reality technologies, prisms or mirrors, may have therapeutic effects for patients suffering from stroke or body image identity disorders. However, there are few studies which directly investigate neural activity changes during visual feedback manipulation. In the present study we created an experimental setup for investigating the effects of systematic virtual reality-mediated visual feedback manipulation of finger movements on cortical activity. We performed tests with two healthy female subjects who performed a line-tracking task under four conditions manipulating visual feedback of their own hand. To investigate hemodynamic responses in motor areas during the line tracking task we used functional near-infrared spectroscopy (fNIRS). We predicted that viewing larger or smaller virtual movements of fingers, compared to the real movements, would affect activity in motor areas and thus the hemodynamic response. Our preliminary results showed changes in the hemodynamic responses between stimulation period and baseline. There were indications of possible differences between conditions, and also of adaptation effects within conditions. However these effects were not significant in our preliminary data and we therefore need to collect additional data to draw further conclusions