Quantum projection filter for a highly nonlinear model in cavity QED

Both in classical and quantum stochastic control theory a major role is played by the filtering equation, which recursively updates the information state of the system under observation. Unfortunately, the theory is plagued by infinite-dimensionality of the information state which severely limits its practical applicability, except in a few select cases (e.g. the linear Gaussian case.) One solution proposed in classical filtering theory is that of the projection filter. In this scheme, the filter is constrained to evolve in a finite-dimensional family of densities through orthogonal projection on the tangent space with respect to the Fisher metric. Here we apply this approach to the simple but highly nonlinear quantum model of optical phase bistability of a stongly coupled two-level atom in an optical cavity. We observe near-optimal performance of the quantum projection filter, demonstrating the utility of such an approach.Comment: 19 pages, 6 figures. A version with high quality images can be found at http://minty.caltech.edu/papers.ph

Methods of model reduction for large-scale biological systems: a survey of current methods and trends

Complex models of biochemical reaction systems have become increasingly common in the systems biology literature. The complexity of such models can present a number of obstacles for their practical use, often making problems difficult to intuit or computationally intractable. Methods of model reduction can be employed to alleviate the issue of complexity by seeking to eliminate those portions of a reaction network that have little or no effect upon the outcomes of interest, hence yielding simplified systems that retain an accurate predictive capacity. This review paper seeks to provide a brief overview of a range of such methods and their application in the context of biochemical reaction network models. To achieve this, we provide a brief mathematical account of the main methods including timescale exploitation approaches, reduction via sensitivity analysis, optimisation methods, lumping, and singular value decomposition-based approaches. Methods are reviewed in the context of large-scale systems biology type models, and future areas of research are briefly discussed