Planet formation in Binaries

Spurred by the discovery of numerous exoplanets in multiple systems, binaries have become in recent years one of the main topics in planet formation research. Numerous studies have investigated to what extent the presence of a stellar companion can affect the planet formation process. Such studies have implications that can reach beyond the sole context of binaries, as they allow to test certain aspects of the planet formation scenario by submitting them to extreme environments. We review here the current understanding on this complex problem. We show in particular how each of the different stages of the planet-formation process is affected differently by binary perturbations. We focus especially on the intermediate stage of kilometre-sized planetesimal accretion, which has proven to be the most sensitive to binarity and for which the presence of some exoplanets observed in tight binaries is difficult to explain by in-situ formation following the "standard" planet-formation scenario. Some tentative solutions to this apparent paradox are presented. The last part of our review presents a thorough description of the problem of planet habitability, for which the binary environment creates a complex situation because of the presence of two irradation sources of varying distance.Comment: Review chapter to appear in "Planetary Exploration and Science: Recent Advances and Applications", eds. S. Jin, N. Haghighipour, W.-H. Ip, Springer (v2, numerous typos corrected

Future Exoplanet Research: Science Questions and How to Address Them

Started approximately in the late 1980s, exoplanetology has up to now unveiled the main gross bulk characteristics of planets and planetary systems. In the future it will benefit from more and more large telescopes and advanced space missions. These instruments will dramatically improve their performance in terms of photometric precision, detection speed, multipixel imaging, high-resolution spectroscopy, allowing to go much deeper in the knowledge of planets. Here we outline some science questions which should go beyond these standard improvements and how to address them. Our prejudice is that one is never too speculative: experience shows that the speculative predictions initially not accepted by the community have been confirmed several years later (like spectrophotometry of transits or circumbinary planets).Comment: Invited review, accepte

The Formation of the First Stars in the Universe

In this review, I survey our current understanding of how the very first stars in the universe formed, with a focus on three main areas of interest: the formation of the first protogalaxies and the cooling of gas within them, the nature and extent of fragmentation within the cool gas, and the physics -- in particular the interplay between protostellar accretion and protostellar feedback -- that serves to determine the final stellar mass. In each of these areas, I have attempted to show how our thinking has developed over recent years, aided in large part by the increasing ease with which we can now perform detailed numerical simulations of primordial star formation. I have also tried to indicate the areas where our understanding remains incomplete, and to identify some of the most important unsolved problems.Comment: 74 pages, 4 figures. Accepted for publication in Space Science Review

Adverse events in healthcare: learning from mistakes

Large national reviews of patient charts estimate that approximately 10% of hospital admissions are associated with an adverse event (defined as an injury resulting in prolonged hospitalization, disability or death, caused by healthcare management). Apart from having a significant impact on patient morbidity and mortality, adverse events also result in increased healthcare costs due to longer hospital stays. Furthermore, a substantial proportion of adverse events are preventable. Through identifying the nature and rate of adverse events, initiatives to improve care can be developed. A variety of methods exist to gather adverse event data both retrospectively and prospectively but these do not necessarily capture the same events and there is variability in the definition of an adverse event. For example, hospital incident reporting collects only a very small fraction of the adverse events found in retrospective chart reviews. Until there are systematic methods to identify adverse events, progress in patient safety cannot be reliably measured. This review aims to discuss the need for a safety culture that can learn from adverse events, describe ways to measure adverse events, and comment on why current adverse event monitoring is unable to demonstrate trends in patient safety

Novel smart glove technology as a biomechanical monitoring tool

Developments in Virtual Reality (VR) technology and its overall market have been occurring since the 1960s when Ivan Sutherland created the world’s first tracked head-mounted display (HMD) – a goggle type head gear. In society today, consumers are expecting a more immersive experience and associated tools to bridge the cyber-physical divide. This paper presents the development of a next generation smart glove microsystem to facilitate Human Computer Interaction through the integration of sensors, processors and wireless technology. The objective of the glove is to measure the range of hand joint movements, in real time and empirically in a quantitative manner. This includes accurate measurement of flexion, extension, adduction and abduction of the metacarpophalangeal (MCP), Proximal interphalangeal (PIP) and Distal interphalangeal (DIP) joints of the fingers and thumb in degrees, together with thumb-index web space movement. This system enables full real-time monitoring of complex hand movements. Commercially available gloves are not fitted with sufficient sensors for full data capture, and require calibration for each glove wearer. Unlike these current state-of-the-art data gloves, the UU / Tyndall Inertial Measurement Unit (IMU) glove uses a combination of novel stretchable substrate material and 9 degree of freedom (DOF) inertial sensors in conjunction with complex data analytics to detect joint movement. Our novel IMU data glove requires minimal calibration and is therefore particularly suited to multiple application domains such as Human Computer interfacing, Virtual reality, the healthcare environment

Effects of the Booroola gene (Fec(B)) on body weight, ovarian development and hormone concentrations during fetal life

The aim of this study was to determine whether the Fec(B) gene influenced some aspects of fetal development in sheep. Carrier (BB/B+) and non-carrier (++) female fetuses were recovered at specific times of gestation, namely, days 40, 55, 75, 90, 95 and 135. The results showed that the Fec(B) gene influenced litter size, body weight and ovarian development during fetal life. The mean litter sizes were larger (P ++; P BB/B+, P BB, P BB/B+, P < 0.05) were independent of litter size. We hypothesize that many of the differences between the Booroola genotypes in ovarian follicular development and pituitary function in neonatal and adult life may be a consequence of differences in the timing or rate of body weight or organ development in fetal life.link_to_subscribed_fulltex

The Irish National Adverse Events Study (INAES): the frequency and nature of adverse events in Irish hospitals—a retrospective record review study

Introduction Irish healthcare has undergone extensive change recently with spending cuts and a focus on quality initiatives; however, little is known about adverse event occurrence. Objective To assess the frequency and nature of adverse events in Irish hospitals. Methods 1574 (53% women, mean age 54 years) randomly selected adult inpatient admissions from a sample of eight hospitals, stratified by region and size, across the Republic of Ireland in 2009 were reviewed using two-stage (nurse review of patient charts, followed by physician review of triggered charts) retrospective chart review with electronic data capture. Results were weighted to reflect the sampling strategy. The impact on adverse event rate of differing application of international adverse event criteria was also examined. Results 45% of charts were triggered. The prevalence of adverse events in admissions was 12.2% (95% CI 9.5% to 15.5%), with an incidence of 10.3 events per 100 admissions (95% CI 7.5 to 13.1). Over 70% of events were considered preventable. Two-thirds were rated as having a mild-to-moderate impact on the patient, 9.9% causing permanent impairment and 6.7% contributing to death. A mean of 6.1 added bed days was attributed to events, representing an expenditure of (sic)5550 per event. The adverse event rate varied substantially (8.6%-17.0%) when applying different published adverse event eligibility criteria. Conclusions This first study of adverse events in Ireland reports similar rates to other countries. In a time of austerity, adverse events in adult inpatients were estimated to cost over (sic)194 million. These results provide important baseline data on the adverse event burden and, alongside web-based chart review, provide an incentive and methodology to monitor future patient-safety initiatives