Chemistry for Sustainable Development 20 (2012) 237250 Synthesis and Biological Activity of the Derivatives of Alkaloid Cytisine

Abstract Results of the investigations carried out by the authors during the past five years in the area of chemical transformation of cytisine alkaloid are presented. A number of new polyfunction al derivatives of cytisine alkaloid containing pharmacone groups including heterocyclic fragments were obtained. The composition and structure of the synthesized compounds were confirmed by means of the data of mass spectrometry, 1 Í NMR spectroscopy and X-ray structural an alysis. Some features of the spatial structure of cytisine were established. The data obtained in the investigation of the biological activity of the synthesized derivatives are presented

Chemistry for Sustainable Development 20 (2012) 537545 Obtaining New Biologically Active Compounds from 2-Vinyloxyethylisothiocyanate

Abstract Via the reaction of alkaloid cytisine, l-ephedrine, d-pseudoephedrine as well as glucosylbenzylamine and xylosylbenzylamine aminoglycosides with vinyloxyethylisothiocyan ate and its acetal derivatives, we synthesized and characterized novel 2-vinyl-, N-1-propargyl-, 1-N-phenyloxyethoxyethylo-N-aminothiourea species. By the example of the N-vinylethoxythiocarbamoyl derivatives of l-ephedrine and d-pseudoephedrine is demonstrated that the mentioned thiourea species could quite readily undergo hydrolyzing in the presence of acids. On the basis of salicylic acid hydrazide we have synthesized and studied the acidic hydrolysis of corresponding vinyloxyethylthiosemicarbazide. The composition and the structure of the thiourea derivatives synthesized were confirmed by IR spectroscopy, 1 H NMR, 13 C NMR and mass spectrometry as well as by XRD structural an alysis