The Impact Of Geographic Location On The Utility Derived From Real-Time Public Transport Information

This paper presents the results of a study undertaken in Dublin, to ascertain passenger preferences for public transport information. The study examines the need for public transport information across three stages of a public transport trip. The stages examined are as follows; stage one: pre-trip planning from home to work, stage two: at-stop/station information, and stage three: pre-trip planning from work to home. At each of these stages, the respondents were asked to choose between several methods of receiving information, via the internet, mobile phone, call centre or at stop real-time information displays. The study utilised a stated preference approach to ascertain what type of information respondents required at each stage and their willingness to pay for this information. This paper presents the findings of the study undertaken and reports several factors which affect respondent’s willingness to pay for public transport information. This paper examines several factors relating to the impact of the geographical location of a respondent in relation to the utility they derive from real-time public transport information. The first factor examined measures the impact that the proximity of an individual to a high quality public transport option has upon utility derived from real-time information. The second factor examines how the residential location of the respondent impacts upon the utility derived from real-time information. Both of these geographical factors were examined using the results of a stated choice experiment conducted in Dublin, Ireland. The first section of this paper presents the survey methodology applied in this study. The following sections present the demographic characteristics of the sample collected and the results of the multinomial logit modelling conducted on the stated choice results. The paper concludes with a discussion and conclusions section.Institute of Transport and Logistics Studies. Faculty of Economics and Business. The University of Sydne

The Impact Of Geographic Location On The Utility Derived From Real-Time Public Transport Information

This paper presents the results of a study undertaken in Dublin, to ascertain passenger preferences for public transport information. The study examines the need for public transport information across three stages of a public transport trip. The stages examined are as follows; stage one: pre-trip planning from home to work, stage two: at-stop/station information, and stage three: pre-trip planning from work to home. At each of these stages, the respondents were asked to choose between several methods of receiving information, via the internet, mobile phone, call centre or at stop real-time information displays. The study utilised a stated preference approach to ascertain what type of information respondents required at each stage and their willingness to pay for this information. This paper presents the findings of the study undertaken and reports several factors which affect respondent’s willingness to pay for public transport information. This paper examines several factors relating to the impact of the geographical location of a respondent in relation to the utility they derive from real-time public transport information. The first factor examined measures the impact that the proximity of an individual to a high quality public transport option has upon utility derived from real-time information. The second factor examines how the residential location of the respondent impacts upon the utility derived from real-time information. Both of these geographical factors were examined using the results of a stated choice experiment conducted in Dublin, Ireland. The first section of this paper presents the survey methodology applied in this study. The following sections present the demographic characteristics of the sample collected and the results of the multinomial logit modelling conducted on the stated choice results. The paper concludes with a discussion and conclusions section.Institute of Transport and Logistics Studies. Faculty of Economics and Business. The University of Sydne

Berberine Reduces cAMP-Induced Chloride Secretion in T84 Human Colonic Carcinoma Cells through Inhibition of Basolateral KCNQ1 Channels

Berberine is a plant alkaloid with multiple pharmacological actions, including antidiarrhoeal activity and has been shown to inhibit Cl− secretion in distal colon. The aims of this study were to determine the molecular signaling mechanisms of action of berberine on Cl− secretion and the ion transporter targets. Monolayers of T84 human colonic carcinoma cells grown in permeable supports were placed in Ussing chambers and short-circuit current measured in response to secretagogues and berberine. Whole-cell current recordings were performed in T84 cells using the patch-clamp technique. Berberine decreased forskolin-induced short-circuit current in a concentration-dependent manner (IC50 80 ± 8 μM). In apically permeabilized monolayers and whole-cell current recordings, berberine inhibited a cAMP-dependent and chromanol 293B-sensitive basolateral membrane K+ current by 88%, suggesting inhibition of KCNQ1 K+ channels. Berberine did not affect either apical Cl− conductance or basolateral Na+–K+-ATPase activity. Berberine stimulated p38 MAPK, PKCα and PKA, but had no effect on p42/p44 MAPK and PKCδ. However, berberine pre-treatment prevented stimulation of p42/p44 MAPK by epidermal growth factor. The inhibitory effect of berberine on Cl− secretion was partially blocked by HBDDE (∼65%), an inhibitor of PKCα and to a smaller extent by inhibition of p38 MAPK with SB202190 (∼15%). Berberine treatment induced an increase in association between PKCα and PKA with KCNQ1 and produced phosphorylation of the channel. We conclude that berberine exerts its inhibitory effect on colonic Cl− secretion through inhibition of basolateral KCNQ1 channels responsible for K+ recycling via a PKCα-dependent pathway

Local air pollution and asthma among over-50s in Ireland. ESRI Research Bulletin 202008 June 2020.

Researchers today published a study showing that over-50s in Ireland living in areas with higher levels of air pollution are more likely to have asthma. The study, published in the International Journal of Epidemiology, was carried out by a team from ESRI, TCD, RCSI, TU Dublin and IT Carlow

Core data set on safety, efficacy, and durability of hemophilia gene therapy for a global registry: Communication from the SSC of the ISTH

BackgroundGene therapy for people with hemophilia (PWH) will soon become available outside current clinical trials. The World Federation of Hemophilia (WFH), in collaboration with International Society of Thrombosis and Hemostasis Scientific and Standardization Committee (ISTH SSC), the European Haemophilia Consortium (EHC), the US National Hemophilia Foundation (NHF), the American Thrombosis and Hemostasis Network (ATHN), industry gene therapy development partners and Regulatory liaisons have developed the Gene Therapy Registry (GTR), designed to collect long- term data on all PWH who receive hemophilia gene therapy.ObjectiveThe objectives of the GTR are to record the long- term safety and efficacy data post gene therapy infusion and to assess the changes in quality of life and burden of disease post- gene- therapy infusion.MethodsThe GTR is a prospective, observational, and longitudinal registry developed under the guidance of a multi- stakeholder GTR Steering Committee (GTR SC), composed of health care professionals, patient advocates, industry representatives, and regulatory agency liaisons. All PWH who receive gene therapy by clinical trial or commercial product will be invited to enrol in the registry through their hemophilia treatment centers (HTCs). The registry aims to recruit 100% of eligible post gene therapy PWH globally. Through an iterative process, and following the guidance of the European Medicines Agency (EMA) and the US Food and Drug Administration (FDA), the GTR SC has developed a core set of data to be collected on all patients post gene therapy.ResultsThe core data set includes demographic information, vector infusion details, safety, efficacy, quality of life and burden of disease.ConclusionsThe GTR is a global effort to ensure that long term safety and efficacy outcomes are recorded and analysed and rare adverse events, in a small patient population, are identified. Many unknowns on the long- term safety and efficacy of gene therapy for hemophilia may also be addressed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/163440/2/jth15023.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/163440/1/jth15023_am.pd

Understanding how institutions may support the development of transdisciplinary approaches to sustainability research

This article analyses the approaches of academics seeking to engage with private, public and community-based stakeholders through transdisciplinary research about pressing sustainability challenges and, in particular, climate change; it outlines aspects of the institutional factors which influence transdisciplinary research. A qualitative approach was employed in conducting 10 semi-structured interviews to analyse the challenges and motivations of academic researchers when working with a range of other stakeholders through transdisciplinary practice. Two key contributions are made through this work. First, this article adds to the existing literature on motivations and challenges for undertaking research with private, public and community stakeholders in a cross-disciplinary manner. Second, the current institutional circumstances influencing such research practices are outlined, alongside potential ways forward. The research presented here has been undertaken in light of the experiences of the two lead co-authors as early career researchers coming from the disciplines of sociology and energy engineering, engaging in transdisciplinary research within a local community context in relation to a regional energy transition project

World Federation of Hemophilia Gene Therapy Registry

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/156126/2/hae14015_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/156126/1/hae14015.pd

A Stated Preference Analysis of Real-Time Public Transit Stop Information

This paper presents the results of a study conducted to examine the benefits derived from real-time public transit stop information. This research examines the preferences between several options of receiving real-time public transit stop information. The literature states that one of the main reasons individuals access real-time information is to remove the uncertainty when using public transit. This relationship was examined to ascertain if the provision of real-time public transit information can remove the uncertainty and frustration associated with using public transit. A nested logit model structure was applied in this study to examine the benefits derived from accessing real-time public transit information. These models are estimated on segments of the dataset to ascertain how the mode of transport used by the respondents impacts the benefits derived from using real-time public transit information. The results of this study demonstrate that passengers derive the greatest benefit from accessing transit stop information from real-time information displays. Respondents were shown to obtain the second highest utility when accessing transit stop information via a mobile phone short message service (SMS). Bus users were found to gain the highest benefit from the provision of real-time transit stop information

Novel aspects of oestrogen actions

Novel aspects of oestrogen actions