11 research outputs found
Amyloidosis Masquerading as Suspected Angioedema: Delay in Diagnosis
- Publication venue
- LVHN Scholarly Works
- Publication date
- 05/05/2016
- Field of study
Recognizing Kikuchi Disease: An Unusually Severe Case.
- Publication venue
- LVHN Scholarly Works
- Publication date
- 27/04/2017
- Field of study
Rhabdomyolysis: An Unusual Presenting Symptom of Hypothyroidism
- Publication venue
- LVHN Scholarly Works
- Publication date
- 02/05/2019
- Field of study
Giant Cell Arteritis Presenting with Bilateral Axillary Artery Occlusions, Vertebral Artery Stenosis and Left Internal Mammary Artery Graft Stenosis
- Publication venue
- LVHN Scholarly Works
- Publication date
- 01/01/2011
- Field of study
Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic
- Author
- 14 | COVIDSurg COllabOratIVe Tzovaras G. (General University Hospital of Larissa)
- Aawsaj Y.
- Abad Gurumeta A.
- Abad-Motos A.
- Abate E.
- Abbott D.
- Abdalla M.
- Abdeldayem H.
- Abdelkader Salama I.
- Abdelkarim M.
- Abdur-Rahman L.
- Abel M. K.
- Aboelkassem Ibrahim A.
- Abou Chaar M. K.
- Abreu da Silva A.
- Abubakar A.
- Acebes García F.
- Achalandabaso Boira M. Sales Mallafré R. (Hospital Universitari de Tarragona Joan XXIII)
- Acher A.
- Acrich E.
- Adamina M.
- Aderombi A.
- Adeyeye A.
- Adiamah A.
- Afonso J.
- Agapov M.
- Agnes A.
- Agostini C.
- Agresta F.
- Aguado H. (Hellín Hospital)
- Aguilar Gonzalez M. Talukder S. (West Suffolk Hospital)
- Ahmed Z.
- Ahmeidat A.
- Ahn J. H.
- Aiken T.
- Aimé A.
- Akalin M.
- Akaydin E.
- Akhtar M. A.
- Akhter Rahman M. M.
- Akin E.
- Al Awwad S.
- Al Habes H.
- Al Maadany F. S. (Al-Jalaa Hospital)
- Al- Khayal K.
- Al- Najjar H.
- Al-Habsi R.
- Al-Masri M.
- Al-Mohammad A.
- Alaa S.
- AlAamer O.
- Aladeojebi A.
- Alam F.
- Alawneh F. (King Hussein Cancer Center). Libya: Alkadeeki G.
- Albertsmeier M.
- Alcaide Matas F.
- Aldokali N.
- Alemanno G.
- Alfieri S.
- Alghamdi M.
- Alhamed A.
- Alharthi M.
- Alhassan N.
- Ali M.
- Ali S.
- Aliyeva Z.
- Aljiffry M.
- Alma Mater Studiorum University of Bologna)
- Almeida A. C.
- Almeida J. I.
- Almeida-Reis R.
- Alnumani T. (King Fahad 16 | COVIDSurg COllabOratIVe General Hospital)
- Alobeed O.
- Alonso de la Fuente N. Jimenez Toscano M. (Hospital del Mar)
- Alonso Poza A.
- Alonso- Lamberti L.
- Alqannas M.
- Alselaim N. (King Saud Bin Abdulaziz University for Health Sciences
- Alshammari S.
- Alsharif F.
- Altintoprak F.
- Alvarez E.
- Alyami M.
- Alzamanan M.
- Amaral M. J.
- Amin Sahid N.
- Amira G.
- Amorim E.
- Anania G.
- Anastasi A.
- Andrade R.
- Angelou D.
- Annamalai S.
- Annessi V.
- Antic A.
- Antonopoulou M. I.
- Anula R.
- Aou Sassari)
- Aprile A.
- Argentina: Alurralde C.
- Arican C.
- Arikan A. E.
- Arkadopoulos N.
- Armao T.
- Armatura G.
- Arminio A.
- Arrowsmith L. Campbell W. (Causeway Hospital)
- Asaad P.
- Ashcroft J.
- Ashmore C.
- Ashoush F.
- Askari A.
- Asqalan A.
- Athanasakis E.
- Athanasiou A.
- Atherton R.
- Attia D.
- Avci E. K.
- Aversano A.
- Ayasra F.
- Ayasra Y.
- Aydin C.
- Ayorinde J.
- Aytac E.
- Ayub B.
- Ayubi A.
- Ayyaz M. (Services Hospital Lahore)
- Azam M.
- Azamat İ. F.
- Azevedo P.
- Babar M. S.
- Baca B.
- Badra R.
- Baena Sanfeliu E.
- Bagraith K.
- Baiao J. M.
- Baig M.
- Baili E.
- Bailón M.
- Bajomo O.
- Baker A.
- Baker O.
- Bakmaz B.
- Balabel M.
- Balasubramaniam D.
- Baldari L.
- Baldi C.
- Baldini E.
- Bali R.
- Balik E.
- Ballabio M.
- Ballouhey Q.
- Baloyiannis I.
- Bandara G. B. K. D.
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- Baptista V. H.
- Barisic G.
- Baron R. D.
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- Barrett J.
- Barrios O.
- Barry C.
- Bartalucci B.
- Bartolini I.
- Basendowah M.
- Bashir Y.
- Bass G. A.
- Bates H.
- Batistotti P.
- Baxevanidou K.
- Baía C.
- Beamish A.
- Beatson K.
- Becker R. Jonescheit J. (Heilig-Geist Hospital Bensheim)
- Beech N.
- Bekheit M.
- Belia F.
- Bellacci A.
- Belli A.
- Bello J.
- Bellora P.
- Belluco C.
- Beltrán de Heredia J.
- Belvedere A.
- Benavides Buleje J. A.
- Benkabbou A.
- Bergamini C.
- Bergeat D. Merdrignac A. (CHU Rennes – General Surgery)
- Bernante P.
- Bernasconi M.
- Berselli M.
- Bertolani E.
- Beyer K.
- Bhalla A.
- Bhangu A.
- Bhangu Aneel
- Bhasin S.
- Bhat M. A.
- Bhatti M. I.
- Bianchini M.
- Bianco F.
- Bianco F. (ASST Papa Giovanni XXIII – Bergamo)
- Bigelow B. (Johns Hopkins Hospital)
- Bilgin I. A.
- Bin Nasser A.
- Bin Traiki T.
- Biondi A.
- Bisagni P.
- Bisset C. Moug S. J. (Royal Alexandra Hospital)
- Blackwell L.
- Blanco-Colino R.
- Blas Laina J. L.
- Blazquez Martin A.
- Bodla A. S.
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- Boeker C.
- Bonci E.
- Bond-Smith G.
- Bondurri A.
- Bong C. Gundara J. (Logan Hospital)
- Boni L.
- Bonnet S.
- Borges F.
- Borges N.
- Borghi F.
- Borroni G.
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- Bouche P. A. Tzedakis S. (Hôpital Cochin – APHP)
- Bouliaris K.
- Boulton A. J. (Good Hope Hospital)
- Boutall A.
- Boutros M.
- Bowman S. Guerra G. R. (Queen Elizabeth II Jubilee Hospital)
- Boyce R.
- Boyd-Carson H.
- Bozkurt E.
- Bozkurt M. A.
- Brachini G.
- Bravo Infante R.
- Brewer H.
- Brito da Silva F.
- Brixton G.
- Brocklehurst M.
- Brown B.
- Brown S.
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- Bruscino A.
- Bueno Cañones A. D.
- Burahee A.
- Burgan D.
- Burke J.
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- Butt U. I.
- Buğra D.
- Cagigal Ortega E. P.
- Cagigas Fernandez C.
- Caiado A.
- Caiña Ruiz R.
- Cakmak G.
- Calabrò M.
- Calvo Espino P. Guillamot Ruano P. (Hospital Universitario de Móstoles)
- Camacho C.
- Caminsky N. G.
- Campagnaro T.
- Campus Benjamin Franklin)
- Canas-Martinez A.
- Cano A.
- Cano-Valderrama O.
- Canonico G.
- Canotilho R.
- Cantalejo Diaz M.
- Capelli P.
- Capezzuoli L.
- Capitan- Morales L.
- Capolupo G. T. Mazzotta E. (Policlinico Universitario Campus Bio Medico of Rome)
- Caram E. L.
- Carbone F.
- Carcoforo P.
- Cardoso N.
- Cardoso P.
- Carrano F. M.
- Carrasco Prats M.
- Carvello M. M.
- Casati M.
- Casiraghi T.
- Cassinotti E. (Fondazione IRCCS Ca’ Granda – Ospedale Maggiore Policlinico di Milano)
- Castellammare di Stabia)
- Castro Ruiz C.
- Cato L. D.
- Cayetano Paniagua L. Gómez Fernández L. (Consorci Sanitari de Terrassa)
- Ceranic M.
- Cervellera M.
- Cervera I.
- Chan E.
- Chan E.
- Chand M.
- Charalabopoulos A.
- Chase T.
- Chatzikomnitsa P.
- Chavarrias N.
- Che Jusoh M. A.
- Chebaro A.
- Chen S.
- Chern H.
- Chessa A.
- Cheung L. K.
- Chevallay M.
- Chia Z.
- Chiappini A.
- Chiarugi M.
- Chiozza M.
- Chitul A.
- Cholewa H.
- Choolani Bhojwani E.
- Choudhry A.
- Chowdhury A.
- Chowdri N. A.
- Choynowski M.
- Christidis P.
- Christoforidis D.
- Chrysos E.
- Chumbinho B.
- Chung E.
- Cianflocca D.
- Cicerchia P. M.
- Cintas Catena J.
- Ciofic E.
- Cirillo B.
- Cirocchi N.
- Claro M.
- Clifford R.
- Clinical Centre of Serbia)
- Coccolini F.
- Cocozza E.
- Coffey J. C.
- Colao García L.
- Collera P.
- Colletti G.
- Colombari R. C.
- Colombo F.
- Confalonieri M.
- Connelly T. M.
- Conti L.
- Conti L.
- Contis I.
- Corbellini C.
- Corless K.
- Correa Bonito A.
- Correia A. M.
- Correia de Sá T.
- Corrigan M.
- Corte Real J.
- Cortés Guiral D.
- Cosimelli M.
- Costa M.
- Costa M. J. M. A.
- Costa Santos D.
- Costanzi A.
- Costeira B.
- Costigan F.
- Cotoia A.
- Cotte E.
- Coughlin P.
- COVIDSurg COllabOratIVe | 15 Violante T. (IRCCS Azienda Ospedaliero – Universitaria di Bologna
- Cozza V.
- Creavin B.
- Crichton A.
- Cristian D.
- Cros B.
- Crugnale A. S.
- Cuadrado-García A.
- Cullivan O.
- Cuming T.
- Cuneo)
- Cunha C.
- Cunha M. F.
- Cunha R.
- Cunningham R. M.
- Curl-Roper T.
- Cvetkovic A.
- Dainius E.
- Daliya P.
- Daly A.
- Danias N.
- Daniels I. R.
- Davies E.
- Davies R. J.
- Day A. (East Surrey Hospital)
- De Andres Olabarria U.
- De Andrés Asenjo B.
- De Lacy F. B.
- De Manzoni Garberini A. (Ospedale Civile Spirito Santo)
- De Miguel Ardevines M. D. C.
- De Nardi P.
- De Palma G. D.
- De Simone V.
- De Sousa X. (Centro Hospitalar de Setúbal)
- De Toma G.
- De Troia A.
- De Vincenti R.
- Del Campo Martín M.
- del Valle E.
- Delgado Búrdalo L.
- Delimpalta C.
- Dellaportas D.
- Delrio P.
- Demir H.
- Demirli Atıcı S.
- Demyttenaere S.
- Denet C.
- Depalma N.
- Department of Biomedical Sciences
- Derksen T.
- Desio M.
- Deus A. C.
- Devezas V.
- Devine M.
- Di Bella A.
- Di Candido F.
- Di Franco G.
- Di Giuseppe M.
- Di Lauro K.
- Di Maria Grimaldi S.
- Di Martino C.
- Di Martino M.
- Di Marzo F. (Valtiberina)
- Diamantis A.
- Diaz Del Gobbo R.
- Diez Alonso M.
- Dijan E.
- Dikicier E.
- Dincer H. A. Erol T. (Hacettepe University Hospital)
- Divya G S.
- Dixon J.
- Diéguez B.
- Domingos J. C.
- Domínguez I.
- Donati D.
- Doyle A.
- Duchalais E. (Nantes University Hospital). Germany: Bork U.
- Dudi-Venkata N. N.
- Duff S.
- Dunne N.
- Duque-Mallén V.
- Durán Ballesteros M.
- Dwidar O.
- Dziakova J.
- Díaz Peña P.
- Díaz Pérez D.
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- D’Aloisio G.
- D’Ugo D.
- D’Ugo S.
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- Earley H.
- Eastmond A.
- Economopoulou P.
- Efthimiou M.
- Egan R.
- Egoroff N.
- El Ahmadi B.
- El Amrani M.
- El Bouazizi Y.
- Elawad A. (King Khalid Hospital)
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- Eldaly A. S. (El-Menshawy Hospital)
- Elkadi H.
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- Elsey E.
- Emerson H.
- Emiroglu M.
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- Emslie K.
- EPE)
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- Escolà D. Jiménez A. (Comarcal Alt Penedés)
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- Foley E.
- Fonseca F. (Instituto Português de Oncologia de Lisboa Francisco Gentil)
- Fonsi G. B.
- Fontana T. (‘Vittorio Emanuele’ – Gela). Japan: Kanemitsu Y.
- Foo C. C. (Queen Mary Hospital). Hungary: Banky B.
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- Galvão D. Vieira A. (Hospital de Santo Espirito da Ilha Terceira)
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- General Surgery Department)
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- Government Medical College). Ireland: Aremu M.
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- Health Affairs
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- King Abdullah International Medical Research Center
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- Krdzic I. (Zvezdara University Medical Center). Singapore: Lieske B. (National University Hospital). South Africa: Almgla N.
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- TU Dresden)
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- Universiti Sains Malaysia)
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- Vergari R. (Ospedali Riuniti di Ancona)
- Vernon L. (Cork University Hospital)
- Vervoort D.
- Vescio G. (University ‘Magna Graecia’ of Catanzaro)
- Vezakis A. (Aretaieion Hospital)
- Videira J. F. (IPO Porto). Réunion: Kassir R.
- Vieira B. (Centro Hospitalar de Trás-Os-Montes e Alto Douro
- Vieira Caroço T. (IPO Coimbra)
- Vieira Paiva Lopes A. C. (Hospital de Torres Vedras – Centro Hospitalar do Oeste)
- Vignali A. (San Raffaele Scientific Institute
- Vigorita V. (Álvaro Cunqueiro Hospital)
- Vijayan D. (Queen Elizabeth Hospital Birmingham)
- Villalabeitia Ateca I. (Hospital Universitario Cruces)
- Vimalachandran D. (Countess of Chester Hospital)
- Viswanath Y. K. S. (James Cook University Hospital)
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- Vucic N.
- Vázquez Fernández A. (Hospital Clínico Universitario de Valladolid)
- Wadham B. (The University Hospital of South Manchester)
- Walkes K. (Queen Elizabeth Hospital). Belgium: Flamey N.
- Wani R. (Sher-I-Kashmir Institute of Medical Sciences)
- Waqar S. H. (Pakistan Institute of Medical Sciences). Poland: Major P. (Jagiellonian University Medical College). Portugal: Azevedo C.
- Warren O. (Chelsea and Westminster Hospital)
- Watson L. J. (Sunderland Royal Hospital)
- Watson N. (King’s Mill Hospital)
- Weitz J.
- Welsch T. (Carl-Gustav-Carus University Hospital
- Werner J. (LMU Klinikum Campus Innenstadt)
- Westwood E. (James Paget University NHS Foundation Trust Hospital)
- Whelan M. (Tallaght University Hospital)
- Whitmore H. (Torbay and South Devon NHS Trust)
- Wilkin R. J. W. (South Warwickshire NHS Foundation Trust)
- Wilkins A. (Hull University Teaching Hospitals NHS Trust)
- Williams G. (Royal Gwent Hospital)
- Williams K. (St George’s Hospital)
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- Wimmer A. (Paracelsus Medical University Salzburg). Barbados: Barker D.
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- Xavier R. G.
- Xenaki S.
- Xynos E. (University Hospital of Heraklion Crete and Interclinic Hospital of Crete). Hong Kong: Futaba K.
- Yang W.
- Yassin N. (Royal Wolverhampton NHS Trust)
- Ye G.
- Yesantharao P.
- Yetkin S. G. (Sisli Hamidiye Etfal Training and Research Hospital)
- Yeşilyurt D. (University of Health Sciences Tepecik Training and Research Hospital)
- Yiallourou A. (Nicosia General Hospital). Czechia: Martinek L.
- Yıldırım A.
- Yildiz A. (Yildirim Beyazit University Yenimahalle Training and Research Hospital). Uganda: Lule H.
- Young R. (York Teaching Hospitals NHS Trust)
- Yousof E. A. (Assiut University Hospital)
- Youssef M. (Norfolk and Norwich University Hospital)
- Yurttas C. (University Hospital Tuebingen)
- Yánez C. (Royo Villanova)
- Yüksel E. (Kocaeli University Teaching Hospital)
- Zafar S. N. (University of Wisconsin)
- Zakaria A. D.
- Zakaria Z. (School of Medical Sciences and Hospital
- Zambon M. (Policlinico Umberto I Sapienza University of Rome)
- Zanus G. (Ca’ Foncello Treviso – DISCOG – Università di Padova)
- Zegarac M. (Institute for Oncology and Radiology of Serbia)
- Zelić M. (University Hospital Center Rijeka)
- Zengin A. K. (Istanbul Universty – Cerrahpaşa Medical Faculty)
- Zerbib P. (CHU Lille)
- Zervas K.
- Zese M. (Santa Maria degli Angeli Hospital ULSS 5 – Adria)
- Zhang H. (Concord Repatriation General Hospital)
- Zizzo M. (Azienda Unità Sanitaria Locale – IRCCS di Reggio Emilia)
- Zografos C. (Laiko University Hospital)
- Zorrilla Ortúzar J. (Hospital General Universitario Gregorio Marañón)
- Zourntou S. (General Hospital of Larissa ‘Koutlimpaneio and Triantafylleio’)
- Zubaidi A. M. (King Saud University). Serbia: Aleksić L.
- Ângelo M.
- Çelebi F.
- Çolak E.
- Öfner D. (Medical University of Innsbruck)
- Öhlberger L.
- Özçelık M. F.
- Öğücü H.
- Überrück L.
- Ćoza I.
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic
Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors
- Author
- Abdellaoui Abdel
- Abramova Liliya
- Adams Mark
- Adams Mark J.
- Adan Roger A. H.
- Adolfsson Rolf
- Adolfsson Rolf
- Adorjan Kristina
- Agartz Ingrid
- Agartz Ingrid
- Agerbo Esben
- Agerbo Esben
- Agerbo Esben
- Aguayo Samuel
- Ahuja Sunil
- Air Tracy M.
- Air Tracy M.
- Al Eissa Mariam
- Albani Diego
- Alda Martin
- Alda Martin
- Alfredsson Lars
- Alfredsson Lars
- Alfredsson Lars
- Alliey-Rodriguez Ney
- Als Thomas D.
- Andlauer Till F. M.
- Ando Tetsuya
- Andreassen Ole A.
- Andreassen Ole A.
- Andreassen Ole A.
- Anjorin Adebayo
- Anjorin Adebayo
- Antilla Verneri
- Antoniou Anastasia
- Appadurai Vivek
- Argyres Dean P.
- Arolt Volker
- Artigas Maria Soler
- Aschauer Harald
- Ashley-Koch Allison E.
- Aslan Mihaela
- Awasthi Swapnil
- Awasthi Swapnil
- Awasthi Swapnil
- Azevedo M. Helena
- Babadjanova Gulja
- Bacanu Silviu-Alin
- Backlund Lena
- Baek Ji Hyun
- Baker Jessica H.
- Ballas Zuhair
- Bass Nicholas
- Bass Nicholas
- Bau Claiton H. D.
- Bauer Michael
- Baune Bernhard T.
- Baune Bernhard T.
- Baune Bernhard T.
- Beckham Jean
- Beckham Jean
- Beckham Jean C.
- Beekman Aartjan T. F.
- Beins Eva C.
- Bellivier Frank
- Bellivier Frank
- Bencko Vladimir
- Bengesser Susanne
- Bergen Andrew W.
- Bergen Andrew W.
- Bergen Sarah E.
- Berger Klaus
- Berger Klaus
- Berrettini Wade H.
- Berrettini Wade H.
- Berrettini Wade H.
- Bhushan Sujata
- Biernacka Joanna M.
- Biernacka Joanna M.
- Bigdeli Tim B.
- Bigdeli Tim B.
- Bigdeli Tim B.
- Binder Elisabeth B.
- Binder Elisabeth B.
- Birgegård Andreas
- Birner Armin
- Blackwood Douglas H. R.
- Boden Joseph M.
- Boehm Ilka
- Boehnke Michael
- Boehnke Michael
- Bohus Martin
- Bohus Martin
- Boks Marco P.
- Boks Marco P.
- Boni Claudette
- Boomsma Dorret I.
- Bosch Rosa
- Bosch Rosa
- Boyko Edward
- Braff David L.
- Brandt Harry
- Brandt Harry
- Breeling James
- Breen Gerome
- Breen Gerome
- Breen Gerome
- Breen Gerome
- Brewer Jessica V.
- Brophy Mary T.
- Brum Murielle
- Brumpton Ben M.
- Brunkhorst-Kanaan Nathalie
- Bryant Richard
- Bryois Julien
- Bryois Julien
- Bryois Julien
- Budde Monika
- Budde Monika
- Buehren Katharina
- Bulik Cynthia M.
- Bulik Cynthia M.
- Burghardt Roland
- Buttenschøn Henriette N.
- Bybjerg-Grauholm Jonas
- Bybjerg-Grauholm Jonas
- Byerley William
- Byrne Enda M.
- Byrne Enda M.
- Bækvad-Hansen Marie
- Bækvad-Hansen Marie
- Bøen Erlend
- Børglum Anders D.
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- Børte Sigrid
- Cahn Wiepke
- Cai Na
- Cairns Murray
- Campos Adrian I.
- Carlberg Laura
- Carr Vaughan J.
- Carter Bruce W.
- Casas Miguel
- Casas Miquel
- Cassina Matteo
- Castelao Enrique
- Castelao Enrique
- Catts Stanley
- Cervantes Pablo
- Cervilla Jorge A.
- Chang Kyong-Mi
- Chang Xiao
- Charney Alexander W.
- Chaumette Boris
- Chen Hsi-Chung
- Chen Wei J.
- Cho Kelly
- Cho Kelly
- Christensen Jane Hvarregaard
- Cichon Sven
- Cichon Sven
- Cichon Sven
- Cichon Sven
- Clarke Toni-Kim
- Clarke Toni-Kim
- Clementi Maurizio
- Cohen David
- Coleman Jonathan R. I.
- Coleman Jonathan R. I.
- Coleman Jonathan R. I.
- Coleman Jonathan R. I.
- Colodro-Conde Lucía
- Cone Roger D.
- Connor Todd
- Constans Joseph
- Coombes Brandon
- Coon Hilary
- Corvin Aiden
- Corvin Aiden
- Courtet Philippe
- Couvy-Duchesne Baptiste
- Craddock Nicholas
- Craddock Nicholas
- Craddock Nick
- Craig David
- Crawford Gregory E.
- Crawford Steven
- Crawford Steven
- Crivelli Silvia
- Crow Scott
- Crow Scott
- Crowley James J.
- Cruceanu Cristiana
- Cuellar-Barboza Alfredo
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- Curtis David
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- Dedoussis George
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- Dellitalia Louis
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- Dennis Michelle F.
- Depaulo J. Raymond
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- Espeseth Thomas
- Estivill Xavier
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- Gupta Samir
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- Harley John
- Hartmann Annette
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- Woodside D. Blake
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- Wray Naomi R.
- Wu Yang
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- Zeggini Eleftheria
- Zerwas Stephanie
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- Zhao Hongyu
- Zhou Hang
- Zillich Lea
- Zillich Lea
- Zipfel Stephan
- Zwart John-Anker
- Świątkowska Beata
- Świątkowska Beata
- Świątkowska Beata
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.Peer reviewe
AI is a viable alternative to high throughput screening: a 318-target study
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- Abaffy Tatjana
- Abraham Elena Theres
- Abrahão Jônatas Santos
- Abramyan Tigran M.
- Agianian Bogos
- Agogo-Mawuli Percy
- Agoulnik Alexander I.
- Agrawal Rajendra K.
- Aguilera Elena
- Ahmed Mostafa
- Akk Gustav
- Akopian Tatos
- Al-Yozbaki Minnatallah
- Aldhamen Yasser Ali
- Alkan Cigdem
- Alramadhani Dina
- Alteen Matthew G.
- Alvarez Guzmán
- Ammendola Serena
- Anastasio Noelle C.
- Anderson Brandon M.
- Anderson Deborah H.
- Andricopulo Adriano D.
- Angell Richard M.
- Anthis Nicholas J.
- Antonelli Lorenzo
- Apfel Athena Marie
- Arias Juan Antonio Sanchez
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- Welsbie Derek S.
- Wentworth Kelly L.
- Wert-Lamas Leon
- White Andrew
- White Simon J.
- Whitesell Luke
- Williams Tiffany
- Wilson Cornelia M.
- Wilson Mark A.
- Windisch Marc P.
- Wong Keith S.
- Woods Virgil A.
- Worley Brad
- Wu Pengpeng
- Wu Xiaoyang
- Wulff Heike
- Xiang Fei
- Xu Hongyang
- Xu Jiake
- Xu Jingyi
- Xu Sophia Q.
- Xu Xin
- Yan Riqiang
- Yang Chao-Yie
- Yen Yun
- Young Matthew A.
- Yu Fang
- Yu Xinfang
- Yuan Haynes
- Yuan Xinrui
- Zahler Stefan
- Zeina Christina M.
- Zelinskaya Natalia
- Zhang Dingqiang
- Zhang Gang
- Zhang Wenjun
- Zhang Xu
- Zhang Yan Jessie
- Zhang Zhiguo
- Zhao Jinshi
- Zhou Han
- Zhou Hui
- Zhou Jia
- Zhou Pei
- Zhou Shan
- Zhu Jiaqi
- Zhu Siran
- Zhu Yini
- Zhuo Ling
- Zochodne Douglas William
- Publication venue
- Publication date
- 01/01/2024
- Field of study
: High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNet® model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery
Robust estimation of bacterial cell count from optical density
- Author
- Aarnio Tiu
- Aaron Leow Chung Yong
- Abbas Anser
- Abduraimova Aiganym
- Abraham Doris
- Acar Beliz Leyla
- Acosta Joaquin
- Adler Nina
- Adulyanukosol Natthawut
- Agena Ejouan
- Agena Ethan
- Aggarwal Priya
- Aguirre Adriana Lizeth Rubio
- Ahlgren Christopher
- Ahuja Janvi
- Aizik Dror
- Akbary Mina
- Akinfenwa Akinwumi
- Akingbesote Ngozi D.
- Akova Umut
- Aldo Ferdinan
- Alexopoulos Ioannis
- Allen Lucy
- Alonso Alejandro
- Altarawneh Dina
- Alvarado Andres Benjamin Sanchez
- Ambre Sanika
- Ameziane Annissa
- Amheine Khadija
- Amin Ihya Fakhrurizal
- Amir Sayeda Sakina
- Amstel Chiel van
- An Yongyan
- Anand Nithishwer Mouroug
- Ananthakrishnan Sathvik
- Anderson Karl
- Angel Sagi
- Annem Vidhya
- Anson Chung Tsun Ho
- Anwar Mariam
- Appel Alana
- Araya Lucas
- Armstrong Alexander
- Arora Neha
- Arora Vasu
- Arruda Beck
- Ashwin F Amal Jude
- Astapenka Artur
- Astles Ben
- Astorino Gabe
- Aubry Celine
- Avileli Rebecca
- Azad Mahnaz Sabeta
- Babar Rehmat
- Babu Priyanka
- Badalli Turan
- Badash Lior
- Baichman-Kass Amichai
- Baldwin Geoff S.
- Baltensperger Oliver Andreas
- Bao Guanke
- Bao Minyue
- Baronaite Ugne
- Barrat Leon Michael
- Barrington Seth
- Barshap Alon
- Bartzoka Natalia
- Basu Anubhav
- Basulto Cynthia
- Bath Scott
- Battina Rohith
- Bauersachs Daniel
- Beal Jacob
- Beale Renee
- Beard Eleanor
- Beck Selina
- Becker Evan
- Benavides Samantha Ayde Pena
- Bennis Nicole
- Bete Anna
- Bhatt Darshak
- Bhowmick Shilpa
- Bian Weixin
- Bijman Eline Yafele
- Bindt Felix
- Blas Karla Soto
- Bo Tang
- Boada Yadira
- Boer Meine
- Bohner Ariel
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- Bott Amie
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- Byun Sumin
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- Chen Ryan
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- Chen Yan
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- Chou Ryan
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- De Silva Nimaya
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- Figueroa Jose Arnulfo Juarez
- Fikry Clara
- Filzen Rachael
- Fischer Matthew
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- Fitzgerald Liza
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- Freire Paulo J. C.
- Friedman Yonatan
- Frohlich Lisa
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- Fulton Leah
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- Giannoula Yvoni
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- Gokul [NO FIRST NAME IN SCOPUS]
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- Secen Mert
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- Selvarajah Vinoo
- Senes Carolina
- Senyuz Ilayda
- Shah Manvi
- Shao Xuze
- Sharma Arth
- Sharma Saksham
- Shaw Nicolette
- Shen Chengwu
- Shen Yishen
- Shen Zhiyuan
- Shengjuan Jiang
- Shi Ruyi
- Shi Ruyi
- Shi Wei
- Shi Yingying
- Shinde Mousami
- Shkolnikov Irene
- Shola Chemay
- Shuan Cheah Matthew Yun
- Shuan Yun
- Shulun [NO FIRST NAME IN SCOPUS]
- Shuyu Shi
- Sia Nympha Elisa M.
- Siemer Jessica
- Sillner Cassandra
- Silva Bruna Fernandes
- Silva Dewuni De
- Simona Magda Faijes
- Sing Lo Ho
- Singh Priyanka
- Sinha Shubhankar
- Sison Abigail
- Sjolin Jacob
- Smet Ignacio Albert
- Smith Caroline
- Smith Ryan
- Smith Zion
- Snaith Eva
- So Kam Pang
- Solano Margarita Sofia Calixto
- Solvang Vanessa
- Somvanshi Tejas
- Son Tinh
- Song Guowei
- Song Haoyue
- Song Li
- Song Yiran
- Song Yong Rafael
- Soni Abhinav
- Sonnier Matt
- Spatharas Panagiotis
- Srinivasan Keerthana
- Standforth Kyle
- Starkel John
- Stewart Thomas
- Stocks Jon
- Strasser Dominik
- Street Morgan
- Stuhlweissenburg Fynn
- Stukenberg Daniel
- Sudarshan Bhuvana
- Suer Gun
- Sumner Kylie
- Sun Dongchang
- Sun Kai
- Sun Shiyu
- Sun Ting
- Suss Beatrix
- Swart Pim
- Sweet Bailey
- Tairan Li
- Takeyasu Reanna
- Tamayo Diana
- Tan Huishuang
- Tan Li Yang
- Tang Cassie
- Tang Christian
- Tang Erting
- Tang Jiaqi
- Tang Weiyi
- Tang Yu-Cheng
- Tang Yu-Hsin
- Tao Yibing
- Tapia Jennifer
- Tariq Ali
- Taskar Poorva
- Taylor Max
- Telesz Lauren
- ten Dam Marjolijn
- Tharp Darron
- Thokachichu Pranav
- Thomas Sophie
- Thormar Eirikur Andri
- Throsberg Christian
- Tian Hong
- Tian Qinghe
- Tian Ruonan
- Tianyi Chang
- Ting Weiyu
- Tirad Alice
- Toanen Marion
- Tobin David
- Toghani Dorsa
- Torell Agnes
- Toro Bibiana
- Torres Ares
- Totten Stephanie
- Trevizo Cynthia Lizeth Gonzalez
- Trivellin Cecilia
- Trujillo-Rodriguez Lidimarie
- Tsai Leona
- Tsai You-Yang
- Tsang Helen
- Tsitsilonis Ourania E.
- Tsui Jennifer
- Tunaj Brigit
- Turner Matthew
- Turton Kristi
- Tutuianu Anna
- Tuzov Vladislav
- Twisk Simone
- Ucan Kutay
- Uday Adwaith B.
- Ueding Elisa
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- Urban Julia
- Uslu Attila
- Vaidya Anjali
- Vaitkus Dovydas
- Vanini Nadine Vaz
- Varaljay Vanessa
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- Velasco Maria Antonia Luna
- Velikov Lukas
- Vella Toni
- Venclovas Tomas
- Venkatraghavan Sankalpa
- Verhagen Mick
- Verma Yashna
- Vignoni Alejandro
- Vincent Annette
- Vincent Sara
- Viswanathan Ashwin
- Vitkute Kornelija
- von Schoenberg Sophie
- Voort Gemma van der
- Vornholt Tobias
- Vries Philip Gorter de
- Waard Jazzy de
- Wadhams George
- Wagner Camille
- Wai Leung Chung
- Wan Chan Tsey
- Wan Leon
- Wan Mitchell
- Wang Cheng-Chieh
- Wang Chenxi
- Wang Choi Seong
- Wang Hao
- Wang Huichao
- Wang Kai
- Wang Kelsey
- Wang Kelsey
- Wang Ken
- Wang Li
- Wang Pengying
- Wang Ping
- Wang Qiupeng
- Wang Raven
- Wang Sibo
- Wang Sihan
- Wang Tian
- Wang Wei
- Wang Xiangxuan
- Wang Xin
- Wang Xinyue
- Wang Xuan
- Wang Xueyao
- Wang Yaling
- Wang Yi
- Wang Yifan
- Wang Yuefei
- Wang Yunyi
- Wang Yuyang
- Wang Yuyao
- Wang Zihao
- Wang Ziru
- Wang Ziyu
- Wanji Li
- Warzecha Heribert
- Watson Emily
- Wawrzyniak Dominika
- Weber Elisa
- Wei Zemeng
- Weile Carl
- Wenhao Xu
- Went Sam
- Whalen Kathleen
- Whiteside Jonny
- Whittle Michaella
- Wickiser Ken
- Windo Joe
- Wintermute Edwin
- Withanage Shamal
- Wolfbeisz Chiara
- Wong Angel
- Wong Hei Man
- Wong Joanne
- Woodward Noble
- Workman C. T.
- Wu Chenhai
- Wu Justin
- Wu Kangjie
- Wu Mengxuan
- Wu Michelle
- Wu Yaxuan
- Wu Yi
- Wu Yuxuan
- Wu Zishi
- Xi Yukun
- Xia Ruoyu
- Xiang Meredith
- Xiang Yuening
- Xiao Ziyang
- Xiaojin Li
- Xiaowen Mao
- Xilei Peng
- Xin Li
- Xin Tian
- Xing Jinming
- Xinguang Chen
- Xinlei Fang
- Xinyu Liu
- Xinyu Liu
- Xinyu Teng
- Xinyue Ma
- Xiong Xin
- Xiong Zhenyu
- Xirui Chen
- Xiu Yao
- Xiujing Hong
- Xu Guiyang
- Xu Hanning
- Xu Hao
- Xu Huandi
- Xu Sheng
- Xu Shirly
- Xu Xia
- Xu Xin
- Xu Yinsong
- Xuan Chen Zi
- Xue Fang
- Xue Han
- Xun Shu
- Yadav Ravineet
- Yadav Yash
- Yadi Liu
- Yan Calvin
- Yan Cathy
- Yan Han
- Yan Hongfa
- Yan Qingyan
- Yan Tsui Shing
- Yan Yeung Wing
- Yan Yining
- Yang Chao
- Yang Chenghao
- Yang Chuyi
- Yang Fan
- Yang Fuqiang
- Yang Hanyeol
- Yang Jake
- Yang Jianzhe
- Yang Jindian
- Yang Jinshu
- Yang Jun
- Yang Leyi
- Yang Ruofan
- Yang Shaobo
- Yang Shuting
- Yang Xilin
- Yang Yuchen
- Yang Zhuoyi
- Yang Zisang
- Yang Zon En
- Yao Andrew
- Yarbrough Hayden
- Yaxi Zhang
- Ye Yusheng
- Yee Chong Yuk
- Yeh Chan-yu
- Yehouessi Tamara
- Yeliseyeva Hanna
- Yesley Phillip
- Yeung Wong Tsz
- Yifan Li
- Yihang Qiu
- Yiming Quan
- Yin Jiacheng
- Yin Lee Ka
- Yin Xianqi
- Yong Nur Liyana Binte Ayub Ow
- Yong Zhangxiang
- Yongjie Lin
- Yoo Hojun
- Yoon Soohyun
- You Jaewon
- Young Cam
- Yu Haimeng
- Yu Jiacheng
- Yu Kai-Chiang
- Yu Liuhong
- Yu Tam Chi
- Yu Wenfei
- Yu Yuen Wai
- Yuan Hetian
- Yuan Long
- Yuan Xing
- Yuan Zhe
- Yuanxu Jiang
- Yucheng Chen
- Yue Qing
- Yueyi Li
- Yuhan Cheng
- Yujie Peng
- Yun Yejie
- Yung Jay
- Yutong Pan
- Zadeh Daniel
- Zamora Alejandro Robles
- Zanoni Paul
- Zanotti Violetta
- Zeng Chenxu
- Zeng Yuanhong
- Zepeng Xu
- Zerva Anastasia
- Zhan Yang
- Zhang Alice
- Zhang Bonan
- Zhang Jianxiang
- Zhang Jige
- Zhang Jinhan
- Zhang Kaida
- Zhang Kecheng
- Zhang Qian
- Zhang Shuyan
- Zhang Tianyi
- Zhang Wanli
- Zhang Xianyin
- Zhang Xinyu
- Zhang Yihao
- Zhang Yuanzhen
- Zhang Yunqian
- Zhang Zixuan
- Zhao Nannan
- Zhao Peng
- Zhao Tianyan
- Zhao Wenxue
- Zhao Yihang
- Zhaoting Li
- Zhecheng Huang
- Zheng Daniel
- Zheng Jiyang
- Zhiwei Song
- Zhong Yanling
- Zhou Hanmi
- Zhou Jiajie
- Zhou Jianan
- Zhou Rui
- Zhou Shuyao
- Zhou Xuanhao
- Zhou Yanjun
- Zhou Yi
- Zhou Yinchi
- Zhou Yineng
- Zhou Yuezhang
- Zhou Yuxin
- Zhou Zhiyu
- Zhu Chushu
- Zhu Ke
- Zhu Xueqian
- Zi Lihan
- Zilinskaite Nemira
- Zimmermann Andreas
- Zimmermann Jennifer
- Zirong Zeng
- Ziwei Zhou
- Ziyi Zhao
- Zorrilla Francisco
- Zou Jiahua
- Zukauskaite Kristina
- Zulueta Patricia
- Zvirblyte Justina
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data
Gastric Antral Vascular Ectasia in Systemic Sclerosis: Demographics and Disease Predictors
- Author
- Publication venue
- LVHN Scholarly Works
- Publication date
- 01/03/2010
- Field of study
OBJECTIVES: To evaluate patients with systemic sclerosis (SSc) who have gastric antral vascular ectasia (GAVE), to further characterize this disease association, and to identify factors that may predict which patients with SSc are at greatest risk for the development of GAVE.
METHODS: Patients with a diagnosis of both SSc and GAVE were identified from the Division of Rheumatology at Georgetown University and Thomas Jefferson University. A chart review was conducted to obtain the demographic data.
RESULTS: Twenty-eight patients were included in this analysis, including 17 with diffuse cutaneous (dcSSc) and 11 with limited cutaneous SSc (lcSSc). The mean disease duration at diagnosis with GAVE was 21.5 months for dcSSc and 84.3 months for lcSSc (p = 0.025). Seventy-six percent of patients with dcSSc developed GAVE within 18 months of first scleroderma symptom onset. Over half of patients with early GAVE also had rapidly progressive cutaneous disease. Only 4% had antitopoisomerase I antibody. Although only 1 patient was tested and had positive RNA polymerase (RNAP) III, RNAP III may be overrepresented in this GAVE population. Mean hematocrit levels were 23.8% in dcSSc and 29% in lcSSc.
CONCLUSION: dcSSc is associated with earlier development of GAVE, as well as more severe anemia requiring more therapeutic interventions. Rapid progression of cutaneous disease may suggest earlier development of GAVE. Absence of antitopoisomerase I antibodies and presence of antibodies to RNAP III/speckled antinuclear antibody pattern may be useful to identify the subset of patients with SSc with increased risk for GAVE
Continuous, but not Intermittent, Antipsychotic Drug Delivery Intensifies the Pursuit of Reward Cues
- Author
- A Abi-Dargham
- A Badiani
- A Pencer
- A Wolkin
- AJ Chesi
- AN Mead
- AN Samaha
- AN Samaha
- Anne-Marie Bédard
- Anne-Noël Samaha
- B Johansson
- CL Danna
- CM Pudiak
- CP O’Brien
- CR Gerfen
- D Levesque
- DA Regier
- Daniel Lévesque
- DC Roberts
- DF Fukushiro
- DF Fukushiro
- DJ Kavanagh
- DN Ruskin
- DO Perkins
- DR Compton
- EJ Khantzian
- FR Schneier
- G Beaudry
- G Paxinos
- G Remington
- G Remington
- GV Rebec
- H de Wit
- H Ericson
- HA Robertson
- J Ichikawa
- J Tauscher
- J Uslaner
- JA Parkinson
- JH Krystal
- JM Holden
- JR Taylor
- Jérôme Maheux
- KC Berridge
- L Farde
- L Farde
- L Gregg
- L Stinus
- LL Howell
- LS Pilowsky
- LV Panlilio
- M Arroyo
- M Le Moal
- M Li
- M Tremblay
- MA Cenci
- ML Wadenberg
- ML Wadenberg
- MS Keshavan
- N Ginovart
- PA LeDuc
- PA LeDuc
- PJ Fletcher
- R Halperin
- RA Chambers
- RC Smith
- RD Palmiter
- RE See
- RJ Beninger
- RR Owen
- S Berretta
- S Kapur
- S Kapur
- S Natesan
- S Potvin
- SB Flagel
- SB Flagel
- TA Kosten
- TE Robinson
- TW Robbins
- TW Robbins
- W Schultz
- Y Shaham
- Publication venue
- Nature Publishing Group
- Publication date
- Field of study
Chronic exposure to antipsychotic medications can persistently change brain dopamine systems. Most studies on the functional significance of these neural changes have focused on motor behavior and few have addressed how long-term antipsychotic treatment might influence dopamine-mediated reward function. We asked, therefore, whether a clinically relevant antipsychotic treatment regimen would alter the incentive motivational properties of a reward cue. We assessed the ability of a Pavlovian-conditioned stimulus to function as a conditioned reward, as well as to elicit approach behavior in rats treated with haloperidol, either continuously (achieved via subcutaneous osmotic minipump) or intermittently (achieved via daily subcutaneous injections). Continuous, but not intermittent, treatment enhanced the ability of amphetamine to potentiate the conditioned reinforcing effects of a cue associated with water. This effect was not related to differences in the ability to attribute predictive value to a conditioned stimulus (as measured by conditioned approach behavior), but was potentially linked to the development of behavioral supersensitivity to amphetamine and to augmented amphetamine-induced immediate early-gene expression (c-fos and Nur77) in dorsal striatopallidal and striatonigral cells. By enhancing the ability of reward cues to control behavior and by intensifying dopamine-mediated striatopallidal and striatonigral cell activity, standard (ie, continuous) antipsychotic treatment regimens might exacerbate drug-seeking and drug-taking behavior in schizophrenia. Achieving regular but transiently high antipsychotic levels in the brain (as modeled in the intermittent condition) might be a viable option to prevent these changes. This possibility should be explored in the clinic