Cycle-starnet: Bridging the gap between theory and data by leveraging large data sets

Advancements in stellar spectroscopy data acquisition have made it necessary to accomplish similar improvements in efficient data analysis techniques. Current automated methods for analyzing spectra are either (a) data driven, which requires prior knowledge of stellar parameters and elemental abundances, or (b) based on theoretical synthetic models that are susceptible to the gap between theory and practice. In this study, we present a hybrid generative domain-adaptation method that turns simulated stellar spectra into realistic spectra by applying unsupervised learning to large spectroscopic surveys. We apply our technique to the APOGEE H-band spectra at R = 22,500 and the Kurucz synthetic models. As a proof of concept, two case studies are presented. The first is the calibration of synthetic data to become consistent with observations. To accomplish this, synthetic models are morphed into spectra that resemble observations, thereby reducing the gap between theory and observations. Fitting the observed spectra shows an improved average cR 2 reduced from 1.97 to 1.22, along with a mean residual reduced from 0.16 to-0.01 in normalized flux. The second case study is the identification of the elemental source of missing spectral lines in the synthetic modeling. A mock data set is used to show that absorption lines can be recovered when they are absent in one of the domains. This method can be applied to other fields that use large data sets and are currently limited by modeling accuracy.T.O. and S.B. acknowledge the support provided for a portion of this research by the Natural Sciences and Engineering Research Council of Canada (NSERC) Undergraduate Student Research Awards (USRA). Y.S.T. is supported by the NASA Hubble Fellowship grant HST-HF2-51425.001 awarded by the Space Telescope Science Institute. K.V. and S.B. acknowledge funding from the National Science and Engineering Research Council Discovery Grants program and the CREATE training program on New Technologies for Canadian Observatories

Epidemiological findings and medical, legal, and public health challenges of an investigation of severe soft tissue infections and deaths among injecting drug users: Ireland, 2000.

In May 2000, public health authorities in Dublin, Ireland, identified a cluster of unexplained severe illness among injecting drug users (IDUs). Similar clusters were also reported in Scotland and England. Concurrent investigations were undertaken to identify the aetiology and source of the illnesses. In Dublin, 22 IDUs were identified with injection-site inflammation resulting in hospitalization or death; eight (36%) died. Common clinical findings among patients with severe systemic symptoms included leukaemoid reaction and cardiogenic shock. Seventeen (77%) patients reported injecting heroin intramuscularly in the 2 weeks before illness. Of 11 patients with adequate specimens available for testing, two (18%) were positive by 16S rDNA PCR for Clostridium novyi. Clinical and laboratory findings suggested that histotoxic Clostridia caused a subset of infections in these related clusters. Empiric treatment for infections among IDUs was optimized for anaerobic organisms, and outreach led to increased enrolment in methadone treatment in Dublin. Many unique legal, medical, and public health challenges were encountered during the investigation of this outbreak

Track E Implementation Science, Health Systems and Economics

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138412/1/jia218443.pd

An unusual cause of abrupt vessel closure

A 60 year old woman presented with chest pain. An ECG showed ST depression across the anterior leads and lateral T wave inversion and angiography showed a significant proximal circumflex lesion. After percutaneous intervention to the circumflex artery she had a cardiac arrest and died. Postmortem examination found a stent blocked with a combination of thrombus and a tangle of translucent material. Embolic coronary artery occlusion is well described but this is the first report of embolisation of material arising from the lining of the guiding catheter as the cause