Timing of Delivery and Adverse Outcomes in Term Singleton Repeat Cesarean Deliveries

To compare the maternal and neonatal risks of elective repeat cesarean delivery compared with pregnancy continuation at different gestational ages, starting from 37 weeks

Effect of Antenatal Corticosteroids on Respiratory Morbidity in Singletons After Late-Preterm Birth

To evaluate whether neonates born to women who had previously received antenatal corticosteroids and then delivered a late-preterm birth neonate had less respiratory morbidity compared with those unexposed to antenatal corticosteroids

Association of Polymorphisms in Neuroprotection and Oxidative Stress Genes and Neurodevelopmental Outcomes After Preterm Birth

To estimate the associations between neuronal homeostasis, neuroprotection, and oxidative stress candidate gene polymorphisms and neurodevelopmental disability

Effect of Antenatal Corticosteroids on Respiratory Morbidity in Singletons After Late-Preterm Birth

OBJECTIVE: To evaluate whether neonates born to women who had previously received antenatal corticosteroids and then delivered a late-preterm birth neonate had less respiratory morbidity compared with those unexposed to antenatal corticosteroids. METHODS: This is a secondary analysis from a multicenter observational study regarding mode of delivery after prior cesarean delivery. We compared women who received one course of antenatal corticosteroids with unexposed parturients, and evaluated various respiratory outcomes among those having a singleton late-preterm birth neonate. We controlled for potential confounders including gestational age at delivery, diabetes, mode of delivery, and maternal race. RESULTS: Five thousand nine hundred twenty-four patients met the inclusion criteria; 550 received steroids, while 5,374 did not. In the univariable model, compared with unexposed women, those who received antenatal corticosteroids appeared more likely to have neonates who required ventilatory support (11.5% v. 8.6%, p=0.022), had respiratory distress syndrome (RDS) (17.1% v. 12.2%, p=0.001), developed transient tachypnea of the newborn (12.9% v. 9.8%, p=0.020), or required resuscitation in the delivery room (55.8% v. 49.7%, p=0.007). After controlling for confounding factors, we found no significant differences among the groups regarding all of the above outcomes with an odds ratio for RDS of 0.78 (95% CI 0.60–1.02) and ventilator support of 0.75 (95% CI 0.55–1.03). CONCLUSION: Exposure to antenatal corticosteroids does not significantly affect respiratory outcomes among those with a subsequent late-preterm birth