Project Evaluation: Tundra Women's Coalition (Bethel), A.W.A.I.C. (Anchorage), Male Awareness Project (Anchorage), Kodiak Women's Resource Center and Kodiak Police Department (Kodiak)

This report presents evaluations of three Alaska agencies that deal with domestic violence: Tundra Women's Coalition in Bethel, through its Family Violence Program; Abused Women's Aid in Crisis (AWAIC) in Anchorage, through its programs for battered women as well as its Male Awareness Program; and Kodiak Women's Resource Center, including its relationship to Kodiak Police Department.Alaska Family Violence Program, Department of Health and Social ServicesFamily Violence Program — Bethel / AWAIC Report / AWAIC Male Awareness Program / Kodiak Women's Resource Center Report / Appendice

DNA methylation networks underlying mammalian traits

Using DNA methylation profiles ( = 15,456) from 348 mammalian species, we constructed phyloepigenetic trees that bear marked similarities to traditional phylogenetic ones. Using unsupervised clustering across all samples, we identified 55 distinct cytosine modules, of which 30 are related to traits such as maximum life span, adult weight, age, sex, and human mortality risk. Maximum life span is associated with methylation levels in subclass homeobox genes and developmental processes and is potentially regulated by pluripotency transcription factors. The methylation state of some modules responds to perturbations such as caloric restriction, ablation of growth hormone receptors, consumption of high-fat diets, and expression of Yamanaka factors. This study reveals an intertwined evolution of the genome and epigenome that mediates the biological characteristics and traits of different mammalian species