The stability of an air-maintained cavity behind a stationary object in flowing water

In studies made in the Free Surface Water Tunnel of a projectile running in an air-maintained cavity, the experimental relation between air entrainment rate and cavitation number was determined. The entrainment-rate coefficient CQ = Q/V0d^2, where Q is the air rate in cfs, V0 the free-stream velocity, and d the disk nose diameter, was plotted against cavitation parameter, K = (p0 - pk)/q0 where p0 is the free-stream pressure at the disk center line, pk the cavity pressure, and q0 the free-stream dynamic pressure. This experimental relationship for one single disc is shown for three different velocities in Fig. 1. The curves are similar in shape and each has a minimum value of entrainment coefficient which is designated by CQ^* at a value of K as designated as K^*

The Hydrodynamics of the Free-Surface Water Tunnel

Free-surface water tunnels are used to determine the hydrodynamic characteristics of bodies which move in water near the surface. To develop the basic principles for the design and operation of such a tunnel the conditions for dynamic similitude near an air-water interface are analyzed. Although the tests should determine how the hydrodynamic characteristics are affected by the surface waves produced by the body itself, the dimensions and conditions of operation of the test channel are sometimes responsible for disturbances that interfere with the interpretation of the local wave effect. In order to record the type of interfering waves that might be expected and the conditions responsible for their occurrence, the Free-Surface Water Tunnel at the Hydrodynamics Laboratory of the California Institute of Technology was temporarily operated under these conditions. Since the local wave pattern produced by the body under study depends primarily on the criterion for inertial-to-gavitational similitude between model tests and prototype operation, the relation between this criterion and the conditions that produce the undesirable channel waves is discussed. Application of gravitational similitude usually results in model tests that are different from prototype operation in respect to viscous and surface-tension effects. A chart is developed showing the relations for gravitational similitude and indicating the resulting dissimilitude for viscous and surface-tension phenomena. This chart is also used to indicate the complete range of operation of a free-surface test channel as well as the range in which undesirable waves are produced in the working section. Through recognition of the nature of the interactions between the hydrodynamic characteristics of the tunnel and the body under investigation, design and operation principles for a free-surface water tunnel are developed showing how to decrease or avoid the wave difficulties and minimize the unavoidable dissimilitude

Multiwavelength Monitoring of the Dwarf Seyfert 1 Galaxy NGC 4395. IV. The Variable UV Absorption Lines

We report the detection of variable UV absorption lines in NGC 4395, based on UV observations with the HST STIS carried out in April and July, 2004, as part of a reverberation-mapping campaign. Low-ionization lines of O I, N I, Si II, C II, and Fe II, are present in the low-state spectra (April 2004) at a velocity v_shift=-250 km/s (system A_l), and additional high-ionization lines of C IV and N V appear in the high-state spectra (July 2004) at v_shift=-250 km/s (system A_h) and at v_shift=-840 km/s (system B). The absence of absorption from the low metastable levels of Si II implies a density <~10^3 cm^(-3) for system A_l, indicating a location outside the narrow line region (NLR). System A_h is peculiar as only N V absorption is clearly detected. A high N V/C IV absorption ratio is expected for a high metallicity absorber, but this is excluded here as the metallicity of the host galaxy and of the nuclear gas is significantly subsolar. A simple acceptable model for systems A_h and B is an absorber located between the broad line region (BLR) and the NLR, which absorbs only the continuum and the BLR. At the low-state the strong narrow emission lines of C IV and N V dominate the spectrum, making the absorption invisible. At the high-state the absorbed continuum and BLR emission dominate the spectrum. Thus, the change in the observed absorption does not reflect a change in the absorber, but rather a change in the continuum and BLR emission from behind the absorber, relative to the emission from the NLR in front of the absorber. Studies of the absorption line variability in highly variable objects can thus break the degeneracy in the absorber distance determination inherent to single epoch studies.Comment: Accepted for publication in The Astrophysical Journa

Necrosis of a Guinea Pig Stomach after Contact with Povidone-Iodine: a Case Report

Rodents are the most frequently used animals in surgical experimentation. It is estimated that guinea pigs in particular are the third most commonly used species in this context. To disinfect guinea pigs’ skin, either alcohol or surgical iodine are most often used. In the context of an animal research project, a Nissen operation was performed in an adult male guinea pig. Because of accidental contamination of the operative field, a 10% povidone-iodine cutaneous solution was applied to the serosa of the anterior wall of the stomach and to the gastric fundus. The guinea pig died 12 hours after surgery due to an acute necrotizing hemorrhagic gastritis. Although there have been a few reports of povidone-iodine toxicity in the guinea pig, as far as the authors could determine, this is the first time that such a serious abdominal complication is reported. The authors believe that the possibility of a similar event should be taken into consideration when planning, executing and interpreting experiments in the guinea pig

Organ failure, outcomes and deprivation status among critically ill cirrhosis patients — a one-year cohort study

No abstract available

Prevalence of disorders recorded in Cavalier King Charles Spaniels attending primary-care veterinary practices in England

Concerns have been raised over breed-related health issues in purebred dogs, but reliable prevalence estimates for disorders within specific breeds are sparse. Electronically stored patient health records from primary-care practice are emerging as a useful source of epidemiological data in companion animals. This study used large volumes of health data from UK primary-care practices participating in the VetCompass animal health surveillance project to evaluate in detail the disorders diagnosed in a random selection of over 50% of dogs recorded as Cavalier King Charles Spaniels (CKCSs). Confirmation of breed using available microchip and Kennel Club (KC) registration data was attempted

Signalment risk factors for cutaneous and renal glomerular vasculopathy (Alabama rot) in dogs in the UK

Seasonal outbreaks of cutaneous and renal glomerular vasculopathy (CRGV) have been reported annually in UK dogs since 2012, yet the aetiology of the disease remains unknown. The objectives of this study were to explore whether any breeds had an increased or decreased risk of being diagnosed with CRGV, and to report on age and sex distributions of CRGV cases occurring in the UK. Multivariable logistic regression was used to compare 101 dogs diagnosed with CRGV between November 2012 and May 2017 with a denominator population of 446,453 dogs from the VetCompass database. Two Kennel Club breed groups—hounds (odds ratio (OR) 10.68) and gun dogs (OR 9.69)—had the highest risk of being diagnosed with CRGV compared with terriers, while toy dogs were absent from among CRGV cases. Females were more likely to be diagnosed with CRGV (OR 1.51) as were neutered dogs (OR 3.36). As well as helping veterinarians develop an index of suspicion for the disease, better understanding of the signalment risk factors may assist in the development of causal models for CRGV and help identify the aetiology of the disease

Demography and disorders of the French Bulldog population under primary veterinary care in the UK in 2013

Abstract Background Despite its Gallic name, the French Bulldog is a breed of both British and French origin that was first recognised by The Kennel Club in 1906. The French Bulldog has demonstrated recent rapid rises in Kennel Club registrations and is now (2017) the second most commonly registered pedigree breed in the UK. However, the breed has been reported to be predisposed to several disorders including ocular, respiratory, neurological and dermatological problems. The VetCompass™ Programme collates de-identified clinical data from primary-care veterinary practices in the UK for epidemiological research. Using VetCompass™ clinical data, this study aimed to characterise the demography and common disorders of the general population of French Bulldogs under veterinary care in the UK. Results French Bulldogs comprised 2228 (0.49%) of 445,557 study dogs under veterinary care during 2013. Annual proportional birth rates showed that the proportional ownership of French Bulldog puppies rose steeply from 0.02% of the annual birth cohort attending VetCompass™ practices in 2003 to 1.46% in 2013. The median age of the French Bulldogs overall was 1.3 years (IQR 0.6–2.5, range 0.0–13.0). The most common colours of French Bulldogs were brindle (solid or main) (32.36%) and fawn (solid or main) (29.9%). Of the 2228 French Bulldogs under veterinary care during 2013, 1612 (72.4%) had at least one disorder recorded. The most prevalent fine-level precision disorders recorded were otitis externa (14.0%, 95% CI: 12.6–15.5), diarrhoea (7.5%, 95% CI: 6.4–8.7), conjunctivitis (3.2%, 95% CI: 2.5–4.0), nails overlong (3.1%, 95% CI% 2.4–3.9) and skin fold dermatitis (3.0%, 95% CI% 2.3–3.8). The most prevalent disorder groups were cutaneous (17.9%, 95% CI: 16.3–19.6), enteropathy (16.7%, 95% CI: 15.2–18.3), aural (16.3%, 95% CI: 14.8–17.9), upper respiratory tract (12.7%, 95% CI: 11.3–14.1) and ophthalmological (10.5%, 95% CI: 9.3–11.9). Conclusions Ownership of French Bulldogs in the UK is rising steeply. This means that the disorder profiles reported in this study reflect a current young UK population and are likely to shift as this cohort ages. Otitis externa, diarrhoea and conjunctivitis were the most common disorders in French Bulldogs. Identification of health priorities based on VetCompass™ data can support evidence–based reforms to improve health and welfare within the breed