Analysis of novel imidazoles from isolated perfused rabbit heart by two high-performance liquid chromatographic methods

The paper reports two analytical high-performance liquid chromatographic methods to detect and quantify cardiac-derived histidyl derivatives. Method A relies on relative hydrophobicities as a basis of separation. Method B is an ion-pairing method in which the compounds are eluted in an entirely different order. Fractions collected from method A have been co-eluted in admixture in method B with authentic reference compounds. Thus the existence of the following imidazole ring-containing compounds derived from heart have been confirmed: N-acetylhistidine, N-acetyl-1-methylhistidine, N-acetylcarnosine, N-acetylhomocarnosine, homocarnosine, anserine, carnosine, balenine. Compounds were found in both tissue samples and perfusates

Carnosine shows alpha-adrenoceptor agonist and antagonist properties in saphenous vein isolated from rabbit

No abstract available

Deliberate introductions of species: Research needs. Benefits can be reaped, but risks are high

The silent invasion of Hawaii by insects, disease organisms, snakes, weeds and other pests is the single greatest threat to Hawaii’s economy and natural environment.... Even one new pest-like the brown tree snake--could forever change the character of our islands. (Coordinating Group on Alien Pest Species 1996, P. 1). Reforestation in the tropics is so vastly behind deforestation that we cannot wait to fully appraise all the potential negative elements of domestication. Weediness is of consequence perhaps in Honolulu, but not in Addis or Delhi. (James Brewbaker, quoted by Hughes 1994, p. 244 )

Carnosine shows alpha-adrenoceptor agonist and antagonist properties in saphenous vein isolated from rabbit

No abstract available

The relationship between the adrenoceptor and nonadrenoceptor-mediated effects of imidazoline- and imidazole-containing compounds

No abstract available

Using Model Based design as an enabler for digital validation of discrete state machines in regulated manufacturing environments

The adoption of Industry 4.0 practices and increased demand for personalised products has resulted in an increased requirement for manufacturers to adopt reconfigurable manufacturing systems. This shift towards reconfigurable systems has been further accelerated due to the recent Covid 19 pandemic, which saw many manufacturers redesign their manufacturing facilities to produce medical equipment. A key activity in designing such equipment is the validation process, which ensures that the equipment performs correctly and satisfies regulatory requirements. This paper proposes a novel methodology whereby model based design is used to design and validate digitally a simple state model, using a model-based design package, in this case MathWorks® Simulink® software. It is demonstrated that the proposed approach can successfully produce the documentation required by GAMP V to validate a model and proves that the proposed approach is a viable method to validate systems in regulated manufacturing environments