2,035 research outputs found

    Nationality, Citizenship and Domicil in the Laws of Nigeria.

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    This thesis deals with two topics of Nigerian Law: (1) the Nationality and Citizenship Laws and (2) the Law of Domicil. The breakdown of the "common code" of British nationality heralded a new phase in the law of nationality and citizenship in the Commonwealth, and the evolution of its members into international relationships led to the enactment of divergent laws in States which previously shared a common nationality code. The emergence of Nigeria as a new independent power enabled the enactment of the first citizenship law. The Introductory Part deals briefly with the historical and constitutional background of Nigeria and a general treatment of the concepts of nationality and citizenship. Part 2 outlines the British Nationality Laws operating in Nigeria prior to October 1, 1960. Part 3 is a comprehensive analysis of the legal provisions for Nigerian citizenship contained in the Constitution, Acts of Parliament and Legal Notices. "Nigerian Nationality" and the concept of nationality in customary law are also considered. The final chapter on Citizenship and Non-Citizenship attempts to analyse the differences in the local law between the possession and non-possession of local citizenship. Part k deals with the second topic. Chapter 9 contrasts domicil with nationality and concludes with an analysis of the content of the law of domicil. Chapter 10 deals with the introduction into Nigeria of the concept of domicil and the scope of its operation, the effect of the federal legal structure on its application, proposals for the reform of the concept in England with a closing reconsideration of it

    Optimal data partitioning, multispecies coalescent and Bayesian concordance analyses resolve early divergences of the grape family (Vitaceae)

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    Evolutionary rate heterogeneity and rapid radiations are common phenomena in organismal evolution and represent major challenges for reconstructing deep-level phylogenies. Here we detected substantial conflicts in and among data sets as well as uncertainty concerning relationships among lineages of Vitaceae from individual gene trees, supernetworks and tree certainty values. Congruent deep-level relationships of Vitaceae were retrieved by comprehensive comparisons of results from optimal partitioning analyses, multispecies coalescent approaches and the Bayesian concordance method. We found that partitioning schemes selected by PartitionFinder were preferred over those by gene or by codon position, and the unpartitioned model usually performed the worst. For a data set with conflicting signals, however, the unpartitioned model outperformed models that included more partitions, demonstrating some limitations to the effectiveness of concatenation for these data. For a transcriptome data set, fast coalescent methods (STAR and MP-EST) and a Bayesian concordance approach yielded congruent topologies with trees from the concatenated analyses and previous studies. Our results highlight that well-resolved gene trees are critical for the effectiveness of coalescent-based methods. Future efforts to improve the accuracy of phylogenomic analyses should emphasize the development of newmethods that can accommodate multiple biological processes and tolerate missing data while remaining computationally tractable. (C) The Willi Hennig Society 2017.National Natural Science Foundation of China [NNSF 31500179, 31590822, 31270268]; National Basic Research Program of China [2014CB954101]; National Science Foundation [DEB0743474]; Smithsonian Scholarly Studies Grant Program and the Endowment Grant Program; CAS/SAFEA International Partnership Program for Creative Research Teams; Laboratory of Analytical Biology of the National Museum of Natural History, Smithsonian Institution; Science and Technology Basic Work [2013FY112100]info:eu-repo/semantics/publishedVersio

    Unraveling the Pharmacokinetic Interaction of Ticagrelor and MEDI2452 (Ticagrelor Antidote) by Mathematical Modeling

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    The investigational ticagrelor-neutralizing antibody fragment, MEDI2452, is developed to rapidly and specifically reverse the antiplatelet effects of ticagrelor. However, the dynamic interaction of ticagrelor, the ticagrelor active metabolite (TAM), and MEDI2452, makes pharmacokinetic (PK) analysis nontrivial and mathematical modeling becomes essential to unravel the complex behavior of this system. We propose a mechanistic PK model, including a special observation model for post-sampling equilibration, which is validated and refined using mouse in vivo data from four studies of combined ticagrelor-MEDI2452 treatment. Model predictions of free ticagrelor and TAM plasma concentrations are subsequently used to drive a pharmacodynamic (PD) model that successfully describes platelet aggregation data. Furthermore, the model indicates that MEDI2452-bound ticagrelor is primarily eliminated together with MEDI2452 in the kidneys, and not recycled to the plasma, thereby providing a possible scenario for the extrapolation to humans. We anticipate the modeling work to improve PK and PD understanding, experimental design, and translational confidence

    BAMBI -A transient 2D-MESFET model with general boundary conditions including Schottky and current controlled contacts

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    Boundary conditions using a current-dependent carrier recombination velocity distribution are developed for modelling Schottky contacts by computer-aided physical simulation. In addition, a boundary condition in the form of an abitrary linear combination of voltage and current at the contact is presented. Thus MESFET devices with simple circuits connected to device terminals can be simulated by solving additional equations. As an example the switching behaviour of a MESFET with a drain resistor is investigated

    Разработка конструкции стенда для испытаний системы выгрузки зерна комбайна КЗС-10К

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    Материалы VIII Междунар. науч.-техн. конф. студентов, магистрантов и молодых ученых, Гомель, 28–29 апр. 2008
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