Developing Ideas and Methods for Supporting Whole Body Interaction in Remote Co-Design with Children

Drawing from a present need as well as a growing interest towards developing methods to engage participants in research remotely [1,2], this workshop focuses on identifying opportunities and challenges around designing with children from an embodiment perspective [3,4,5,6,10,11,12,13,15]. Themed around whole body interaction and digital technologies [3,7,8,9,10,11,14,15,16,17,18,20,21] the aim of this workshop is to gain methodological insights for the remote participation of children in design, and arrive at design insights addressing the question how we can design remote, inclusive whole body interactions for and with children while attending to child participants’ multimodal communication and bodily engagement [19,21] in a physically dislocated setting [1,2]. The workshop will involve discussions around data gathering from different angles, including relational, ethical, safety and practical perspectives, to create a comprehensive picture of what it entails to orchestrate embodied co-design workshops with children virtually. Outputs from the workshop will contribute to the IDC community by offering methodological insights from attendees’ own experience and presented case studies from researchers and practitioners from both non-academic and academic settings to support children's embodied engagement in remote workshop situations and beyond

Primary and secondary scintillation measurements in a xenon Gas Proportional Scintillation Counter

NEXT is a new experiment to search for neutrinoless double beta decay using a 100 kg radio-pure high-pressure gaseous xenon TPC. The detector requires excellent energy resolution, which can be achieved in a Xe TPC with electroluminescence readout. Hamamatsu R8520-06SEL photomultipliers are good candidates for the scintillation readout. The performance of this photomultiplier, used as VUV photosensor in a gas proportional scintillation counter, was investigated. Initial results for the detection of primary and secondary scintillation produced as a result of the interaction of 5.9 keV X-rays in gaseous xenon, at room temperature and at pressures up to 3 bar, are presented. An energy resolution of 8.0% was obtained for secondary scintillation produced by 5.9 keV X-rays. No significant variation of the primary scintillation was observed for different pressures (1, 2 and 3 bar) and for electric fields up to 0.8 V cm-1 torr-1 in the drift region, demonstrating negligible recombination luminescence. A primary scintillation yield of 81 \pm 7 photons was obtained for 5.9 keV X-rays, corresponding to a mean energy of 72 \pm 6 eV to produce a primary scintillation photon in xenon.Comment: 16 pages, 10 figures, accepted for publication in JINS

Chapter 3: Choosing the Important Outcomes for a Systematic Review of a Medical Test

In this chapter of the Evidence-based Practice Centers Methods Guide for Medical Tests, we describe how the decision to use a medical test generates a broad range of outcomes and that each of these outcomes should be considered for inclusion in a systematic review. Awareness of these varied outcomes affects how a decision maker balances the benefits and risks of the test; therefore, a systematic review should present the evidence on these diverse outcomes. The key outcome categories include clinical management outcomes and direct health effects; emotional, social, cognitive, and behavioral responses to testing; legal and ethical outcomes, and costs. We describe the challenges of incorporating these outcomes in a systematic review, suggest a framework for generating potential outcomes for inclusion, and describe the role of stakeholders in choosing the outcomes for study. Finally, we give examples of systematic reviews that either included a range of outcomes or that might have done so. The following are the key messages in this chapter: Consider both the outcomes that are relevant to the process of testing and those that are relevant to the results of the test.Consider inclusion of outcomes in all five domains: clinical management effects, direct test effects; emotional, social, cognitive and behavioral effects; legal and ethical effects, and costs.Consider to which group the outcomes of testing are most relevant.Given resource limitations, prioritize which outcomes to include. This decision depends on the needs of the stakeholder(s), who should be assisted in prioritizing the outcomes for inclusion

Methylation-Specific MLPA (MS-MLPA): simultaneous detection of CpG methylation and copy number changes of up to 40 sequences

Copy number changes and CpG methylation of various genes are hallmarks of tumor development but are not yet widely used in diagnostic settings. The recently developed multiplex ligation-dependent probe amplification (MLPA) method has increased the possibilities for multiplex detection of gene copy number aberrations in a routine laboratory. Here we describe a novel robust method: the methylation-specific MLPA (MS-MLPA) that can detect changes in both CpG methylation as well as copy number of up to 40 chromosomal sequences in a simple reaction. In MS-MLPA, the ligation of MLPA probe oligonucleotides is combined with digestion of the genomic DNA–probe hybrid complexes with methylation-sensitive endonucleases. Digestion of the genomic DNA–probe complex, rather than double-stranded genomic DNA, allowed the use of DNA derived from the formalin treated paraffin-embedded tissue samples, enabling retrospective studies. To validate this novel method, we used MS-MLPA to detect aberrant methylation in DNA samples of patients with Prader–Willy syndrome, Angelman syndrome or acute myeloid leukemia