Gallium arsenide (GaAs) power conversion concept

A summary design analysis of a GaAs power conversion system for the solar power satellite (SPS) is presented. Eight different satellite configuration options for the solar arrays are compared. Solar cell annealing effects after proton irradiation are considered. Mass estimates for the SPS and the effect of solar cell parameters on SPS array design are discussed

High voltage systems (tube-type microwave)/low voltage system (solid-state microwave) power distribution

SPS satellite power distribution systems are described. The reference Satellite Power System (SPS) concept utilizes high-voltage klystrons to convert the onboard satellite power from dc to RF for transmission to the ground receiving station. The solar array generates this required high voltage and the power is delivered to the klystrons through a power distribution subsystem. An array switching of solar cell submodules is used to maintain bus voltage regulation. Individual klystron dc voltage conversion is performed by centralized converters. The on-board data processing system performs the necessary switching of submodules to maintain voltage regulation. Electrical power output from the solar panels is fed via switch gears into feeder buses and then into main distribution buses to the antenna. Power also is distributed to batteries so that critical functions can be provided through solar eclipses

Direkte Reninhemmer oder Kirene

Zusammenfassung: Die direkten Reninhemmer (DRI) bilden eine neue Klasse blutdrucksenkender Arzneimittel. Wie die ACE-Hemmer und die Angiotensinrezeptorblocker (ARB) dämpfen sie das Renin-Angiotensin-Aldosteronsystem (RAAS). Als gut verträgliche und hochspezifische Therapeutika senken sie die Plasmaspiegel sämtlicher Angiotensine und dürften in Zukunft erfolgreich bei Herz-Kreislauf- und Nierenkrankheiten eingesetzt werden. DRI verursachen weder Husten noch Angioödeme, was sie vor den ACE-Hemmern auszeichnet. Auch metabolische Nebenwirkungen fehlen (keine Dyslipidämie, Hyperurikämie, Diabetes...). DRI können als Alternative oder als Kombinationspartner zu anderen RAAS-Blockern (ARB, ACE-Hemmern, β-Blockern, Aldosteronantagonisten), Kalziumantagonisten oder Diuretika werden verwendet. Aliskiren/Rasilez® ist ein erster lang wirksamer und gut verträglicher Reninhemmer, der als Monotherapie oder in Kombination mit anderen Antihypertensiva eingesetzt wir

The Existence of the Covenant before and after Christ in Galatians 3.15-18: A Conversation with James D.G. Dunn and J. Louis Martyn

This study looks at Galatians 3. 15-18 by entering the scholarly conversation of J. Louis Martyn and James Dunn: 1) evaluating their claims on the issue of \u27continuity\u27 and \u27discontinuity\u27 as it is adjudicated in Galatians, 2) allowing questions to emerge from this analysis, and 3) letting the sounding of this dialogue bring forth a new exegetical voice to speak about the original text. It asks the questions: How does Paul already find continuity between the past and present constructions of the covenantal community, in the face of the opponents\u27 belief that they must enforce a continuity that is presently being sacrificed? And, is Paul really claiming that the people of God in Christ is a creation ex nihilo, having no relationship to the people of God we find in Israel\u27s scriptures? To answer these questions one must read Paul through his understanding of the promise/faith dynamic initiated in God\u27s relationship to Abraham. One must read through Paul\u27s fastening of Christ in the past, present, and future as one who hears the promises with Abraham, as one who is bound up in the destiny of the already formed people of God, and as one who is also the instrument of that destiny\u27s present fulfillment

Social uncertainty is heterogeneous and sometimes valuable

To win friends, help the needy, avoid exploitation or influence strangers, people must make decisions that are inherently uncertain. In their compelling and insightful perspective on resolving social uncertainty1, FeldmanHall and Shenhav (henceforth F&S) join a growing movement combining computational approaches with social psychological theory. F&S identify a range of negative and positive aspects of social uncertainty. Here we offer additional ways to think about social uncertainty and suggest potential avenues for future research

Plasma Angiotensin II and the Antihypertensive Action of Angiotensin-Converting Enzyme Inhibition

The measurement of immunoreactive "angiotensin II” in plasma cannot provide an accurate reflection of the efficacy of angiotensin-converting enzyme (ACE) inhibition because different angiotensin fragments interfere in all radioimmunoassays available so far. More complex methods are necessary in order to measure specifically angiotensin-(1-8)octapeptide. With such methodology it can be shown that no tolerance develops to the angiotensin II-reducing effect of ACE inhibitors after prolonged administration. Marked reduction of angiotensin II levels can be shown even in patients with primary aldosteronism. At peak blockade, the level of plasma angiotensin II is still related to circulating active renin and angiotensin I. Accordingly, because ACE inhibitors raise circulating angiotensin I in a dose-dependent fashion, this should be taken into account when dosing ACE inhibitors. The hypothesis that tissue renin-angiotensin systems play an important independent role in determining vasomotor tone is very interesting. However, any discussion on whether tissue or plasma renin determines the pharmacological effect of ACE inhibitors should be based on the simultaneous measurement of true angiotensin II in tissue and plasma under steady-state conditions. Am J Hypertens 1989;2:286-29

Aging and Human Hormonal and Pressor Responsiveness to Angiotensin II Infusion With Simultaneous Measurement of Exogenous and Endogenous Angiotensin II

A decline in the function of the renin angiotensin aldosterone system may induce adaptive changes in response to angiotensin II (ANG II) with age. We have examined platelet ANG II receptor density, blood pressure and aldosterone responses to ANG II [Asn1, Val5-ANG II] (Hypertensin, Ciba Geigy, Horsham, Sussex, England) infusion in 8 young, 24 to 30 years, and 8 older, 54 to 65 years, healthy volunteers. To measure circulating ANG II, we established a new method for specific and simultaneous measurement of exogenous [Asn1,Val5] (Hypertensin) and endogenous [Asp1,Ile5] ANG II in plasma by using isocratic HPLC and radioimmunoassays with cross-reacting antibodies and compared results with immunoreactive ANG II which was measured conventionally using monoclonal antibodies. Baseline endogenous ANG II (Asp1,Ile5-ANG II) levels in venous plasma were marginally, but not significantly, lower in the old [mean (95% confidence limits): 3.4 (< 0.1 to 7.7) ν 3.7 (1.2 to 6.2), fmol/ mL] and during suppression by the Hypertensin infusion appeared consistently, but not significantly, lower in the old [0.9 (0 to 3.1) ν 2.1 (0.6 to 3.7), after 3 ng/kg/min], while the same infusion rate in young and old resulted in similar plasma Hypertensin levels. Baseline systolic blood pressure (SBP) was similar in both groups but the percentage increases in SBP at infusion rates of 1, 3.0, and 10 ng/kg/min were greater in the old than in the young (9.1 ν 2.8, Ρ<.05; 16.3 ν 8.0, Ρ<.01; 30.4 ν 14.0%, Ρ<.001, respectively). The increment in diastolic blood pressure or mean arterial pressure during infusion did not differ significantly between the groups. Heart rate fell significantly during ANG II infusion in young (P < .05) but not old subjects. Basal plasma aldosterone was similar in both groups. However, the percentage increases in plasma aldosterone were greater in young than old at infusion rates of 1.0, 3.0, and 10.0 ng/kg/min (94 ν - 5 ; 238 ν 28; 462 ν 69%, all Ρ<.001). Platelet ANG II receptor density was elevated in the old [6.5 (1.9 to 11.1) ν 1.14 (0.21 to 2.07), fmol/109 cells, Ρ<.01]. Our findings demonstrate that it is possible to measure specifically and simultaneously exogenous and endogenous ANG II in plasma during Hypertensin infusion and that endogenous ANG II concentrations decrease with increasing levels of exogenous ANG II. During infusion, similar plasma Hypertensin levels were attained in both young and old, but systolic blood pressure responsiveness was increased in the old, while adrenal responsiveness was reduced. Am J Hypertens 1993;6:641-64

Volume expansion enhances plasma endothelin-1

We hypothesized that acute volume expansion by saline infusion triggers the release of endothelin-1. Bolus intravenous saline infusion (8 mL/min) in six groups of conscious Wistar rats and spontaneously hypertensive rats did not change mean arterial pressure or heart rate (n = 8 to 12). At 1 min after infusion, the plasma endothelin-1 level was significantly increased in Wistar rats and in spontaneously hypertensive rats by 42% and 61%, respectively (unpaired data). In 12 Wistar rats, the endothelin-1 level increased from 0.68 ± 0.13 to 1.19 ± 0.17 fmol/mL (mean ± SEM, P < .0001, paired data). Thus, acute volume load by rapid saline infusion increases plasma endothelin-1 levels. Vasoconstriction induced by endothelin-1 may counteract enhanced circumferential stretch created by volume expansion. Am J Hypertens 2003;16:1057-1061 @ 2003 American Journal of Hypertension, Lt