The Effect Of Aerosolised-Honey On Inflammation, Regeneration And Repair Of Airway Epithelia In Rabbit Model Of Ovalbumin-Induced Chronic Lung Injury

For the past few decades, chronic lung injury has attributed to thousands of death worldwide. The disease occurred due to alteration in the structure as well as cellular components of the airways which later lead to airway remodelling and inflammation. This disease is not curable; however, treatments are available to reduce the disease symptoms and preventing the disease progression. At the clinical setting, conventional drug therapy is available to lessen disease exacerbations; however, there is still a need to find the alternative treatments that incorporated with natural resources to minimize the side effect of drug therapy

The Rabbit as a Model for Studying Lung Disease and Stem Cell Therapy

No single animal model can reproduce all of the human features of both acute and chronic lung diseases. However, the rabbit is a reliable model and clinically relevant facsimile of human disease. The similarities between rabbits and humans in terms of airway anatomy and responses to inflammatory mediators highlight the value of this species in the investigation of lung disease pathophysiology and in the development of therapeutic agents. The inflammatory responses shown by the rabbit model, especially in the case of asthma, are comparable with those that occur in humans. The allergic rabbit model has been used extensively in drug screening tests, and this model and humans appear to be sensitive to similar drugs. In addition, recent studies have shown that the rabbit serves as a good platform for cell delivery for the purpose of stem-cell-based therapy