Synthesis, structural characterization and in vitro cytotoxicity of diorganotin complexes with schiff base ligands derived from3-hydroxy-2-naphthoylhydrazide

A series of diorganotin complexes with Schiff base ligands, (E)-N'-(5-bromo-2-hydroxybenzylidene)-3-hydroxy-2-naphthohydrazide, H2L1, and (E)-N'-(5-chloro-2-hydroxybenzylidene)-3-hydroxy-2-naphthohydrazide, H2L2, were synthesized and characterized by elemental analysis, IR, 1H, 13C and 119Sn NMR spectroscopy. The molecular structures of the complexes, [(5-bromo-2-oxidobenzylidene)-3-hydroxy-2-naphthohydrazidato]di(o-chlorobenzyl)tin(IV) 6 and [(5-chloro-2-oxidobenzylidene)-3-hydroxy-2-naphthohydrazidato]dibutyltin(IV) 9, were determined through single-crystal X-ray diffraction and revealed a distorted trigonal-bipyramidal configuration. The in vitro cytotoxic activity of the Schiff bases and their diorganotin complexes was also evaluated against several human carcinoma cell lines, namely HT29 (human colon carcinoma cell line), SKOV-3 (human ovarian cancer cell line), MCF7 (hormone-dependent breast carcinoma cell line) and MRC5 (non-cancer human fibroblast cell line). [(5-Bromo-2-oxidobenzylidene)-3-hydroxy-2-naphthohydrazidato]dibutyltin(IV) 2 and [(5-bromo-2-oxidobenzylidene)-3-hydroxy-2-naphthohydrazidato]dibenzyltin(IV) 5 were the most active diorganotin complexes of H2L1 ligand. Among the diorganotin complexes of H2L2 ligand, [(5-chloro-2-oxidobenzylidene)-3-hydroxy-2-naphthohydrazidato]dicyclohexyltin(IV) 11 showed good cytotoxic activity against all the tested cell lines. As such, the above compounds can be considered agents with potential anticancer activities, and can therefore be investigated further in in vitro or in vivo anticancer studies. Copyright (c) 2012 John Wiley & Sons, Ltd

Cytotoxic activity of leaf and rhizome extracts of Alpinia scabra (Blume) Naves, a wild ginger from peninsular Malaysia

The leaves and rhizomes of Alpinia scabra (Zingiberaceae) were investigated for their cytotoxic effect against selected human cancer cell lines, namely MCF7 (hormone-dependant breast carcinoma cell line), HT29 (colon carcinoma cell line) and SKOV-3 (ovarian cancer cell line) by using an in vitro neutral red cytotoxicity assay. The methanol extracts of both leaves and rhizomes did not show active cytotoxic activity against the selected cancer cell lines. The n-hexane extract of the leaves exhibited remarkable cytotoxic effect against SKOV-3 cells with IC(50) value of 6.3 mu g/ml while dichloromethane extract showed high cytotoxic effect against MCF7 and SKOV-3 with IC(50) values of 6.7 and 5.9 mu g/ml, respectively. The n-hexane and dichloromethane extracts of the rhizomes possessed high cytotoxic effect against SKOV-3 cells with IC(50) values of 8.3 and 7.0 mu g/ml, respectively. This is the first report of the cytotoxic activity of A. scabra