Dimethyl (2-hydr­oxy-4-phenyl­but-3-en-2-yl)phospho­nate

In the title compound, C12H17O4P, the phenyl­butenyl group is disordered over two sets of sites with an occupancy ratio of 0.755 (12):0.245 (12). In the crystal, inversion dimers linked by pairs of O—H⋯O hydrogen bonds occur, forming R 2 2(10) ring motifs. The packing is consolidated by weak C—H⋯π inter­actions

Dimethyl (1-hydr­oxy-1,2-diphenyl­ethyl)phospho­nate

In the mol­ecule of the title compound, C16H19O4P, the coordination around the P atom is distorted tetra­hedral. The aromatic rings are oriented at a dihedral angle of 72.28 (11)°. Intra­molecular C—H⋯O hydrogen bonding result in the formation of five- and six-membered rings. In the crystal structure, inter­molecular C—H⋯O hydrogen bonds link the mol­ecules. There is also a weak C—H⋯π inter­action

Dimethyl [hydr­oxy(2-nitro­phen­yl)meth­yl]phospho­nate

In the title compound, C9H12NO6P, intra­molecular C—H⋯O hydrogen bonds form five- and six-membered rings. In the crystal, inversion dimers lined by pairs of C—H⋯O hydrogen bonds occur with ring motifs R 2 2(10). The O atom of the hydr­oxy group behaves as an accepter and the benzene ring as donor. Adjacent dimers are connected through O—H⋯O links

Diethyl (1-hydr­oxy-1-phenyl­ethyl)phospho­nate

The title compound, C12H19O4P, has a distorted tetra­hedral geometry around the P atom. The molecules form dimers with R 2 2(10) ring motifs due to inter­molecular O—H⋯O hydrogen bonds. The double-bonded O atom of the phospho­nate group behaves as an acceptor and the hydr­oxy group acts as a donor. Both of the ethyl groups are disordered with occupancies of 0.55:0.45 and 0.725:0.275

A kinetic study of mercury(II) transport through a membrane assisted by new transport reagent

Background: A new organodithiophosphorus derivative, namely O-(1,3-Bispiperidino-2-propyl)-4-methoxy phenyldithiophosphonate, was synthesized and then the kinetic behavior of the transport process as a function of concentration, temperature, stirring rate and solvents was investigated.Results: The compound 1 was characterized by elemental analysis, IR, H-1 and P-31 NMR spectroscopies. The transport of mercury(II) ion by a zwitterionic dithiophosphonate 1 in the liquid membrane was studied and the kinetic behavior of the transport process as a function of concentration, temperature, stirring rate and solvents was investigated. The compound 1 is expected to serve as a model liquid membrane transport with mercury(II) ions.Conclusion: A kinetic study of mercury(II) transport through a membrane assisted by O-(1,3-Bispiperidino-2-propyl)4-methoxy phenyldithiophosphonate was performed. It can be concluded that the compound 1 can be provided a general and straightforward route to remove toxic metals ions such as mercury(II) ion from water or other solution

Ankilozan spondilit hastalarında işitmenin odyometri, multifrekans timpanometri testi ve geçici uyarılmış otoakustik emisyon testleriyle değerlendirilmesi

Ankilozan spondilit (AS); etiyolojisi henüz bilinmeyen, özellikle omurga ile sakroiliak eklemleri etkileyen, göz, kalp, akciğer, böbrek ve bağırsak gibi organların tutulumuna bağlı klinik bulguların da eşlik edebildiği, kronik sistemik inflamatuar bir hastalıktır. Çalışmamızın amacı; ankilozan spondilit hastalarında orta kulak, iç kulak ve eferent işitme sistemini, multifrekans timpanometri, geçici uyarılmış otoakustik emisyon (TEOAE) ve kontralateral supresyon testi ile detaylı olarak incelemektir. Çalışmaya 33 AS, 36 sağlıklı kişi olmak üzere toplam 69 kişi alınmıştır. Katılımcıların immitansmetrik ölçümleri yapıldıktan sonra saf ses odyometrisi uygulanarak işitme eşikleri ölçülmüştür. Daha sonra her iki grubun uyarılmış otoakustik emisyon testiyle değerlendirmesi: kontralateral akustik stimülasyon (KAS) verilmeden önce ve 70 dB dar band kontralateral akustik stimülasyon verilirken olacak şekilde iki aşamalı olarak ölçülmüştür. Ankilozan spondilit hastalarının yaş ortalaması 41,58±7,7, kontrol grubunun yaş ortalaması 38,19±8,7 olup, fark istatistiksel olarak anlamlı bulunmadı (p=0,086). 125Hz-16000 Hz frekansları arasında ankilozan spondilit ve kontrol grubu saf ses işitme eşikleri karşılaştırıldığında, bütün frekanslarda AS hastalarının saf ses işitme eşikleri daha yüksek olarak bulundu. Bu fark, sağ kulakta 2000 Hz, 4000 Hz ve 10000 Hz, sol kulakta 2000 Hz ve 10000 Hz frekansları haricinde tüm frekanslarda istatistiksel olarak anlamlı bulundu (p0,05). Otoakustik emisyon testiyle yapılan değerlendirmede, iki grup TEOAE sonuçları karşılaştırıldığında ankilozan spondilitli hastalardan alınan emisyon yanıtları kontrol grubuna göre 1000Hz, 2000Hz ve 4000Hz frekanslarında istatistiksel olarak anlamlı düşük saptandı (p0,05). Sonuç olarak elde ettiğimiz bulgular göstermektedir ki, AS hastalığında iç kulak bir hedef organ olabilmektedir. Ankilozan spondilit tanısı konulduğunda hastaların odyolojik değerlendirmesi de yapılmalı ve hastalar olası otolojik tutulum hakkında bilgilendirilmelidir. Ankilozan spondilit hastalarında orta ve iç kulak fonksiyonlarının etkilenimi ve bu olası etkilenimler ile ilişkili olabilecek hastalık özelliklerine yönelik çalışmalara devam edilmelidir. Ankylosing spondylitis (AS) is a chronic systemic inflammatory disease that etiology is yet known, especially effect spine and sacroiliac joints, also may be accompanied the clinical findings due to the involvement of organs such as eye, heart, lung, kidney and intestine. The aim of our work was to examine middle ear, inner ear and efferent auditory system by using multifrequency tympanometry, transient evoked otoacoustic emission (TEOAE) and contralateral suppression test in detail. A total of 69 subjects; 33 patients with AS and 36 healthy subjects participated in the study. Immitansmetric measurements of participants were performed, and then their hearing levels were measured applying pure tone audiometry. The evaluation of each group with otoacoustic emission test was performed in two stages: before giving contralateral acoustic stimulation (CAS) and during 70 dB narrow band contralateral acoustic stimulation. Mean age of patients with ankylosing spondylitis was 41,58±7,7, mean age of control group was 38,19±8,7 and the difference between groups was not statistically significant (p=0,086). By comparison pure tone hearing levels between ankylosing spondylitis and control group at 125Hz-16000 Hz frequency, pure tone hearing levels of AS patients at all frequencies were higher. These differences were found statistically significant except 2000 Hz, 4000 Hz and 10000 Hz in right ear, 2000 Hz and 10000 Hz in left ear (p0,05). When compared two groups‟ TEOAE results, emission results received from ankylosing spondylitis patients were statistically significantly lower than control group at 1000Hz, 2000Hz and 4000Hz frequencies by using otoacoustic emission test (p0,05). As a result, our findings indicate that inner ear in ankylosing spondylitis may be target organ. When the ankylosing spondylitis is diagnosed, the patients should be undergo audiologic evaluation and informed about possible pathological involvement. Future studies should continue about middle and inner ear condition in ankylosing spondylitis patients and potential interactions that may be associated with disease characteristics

Syntheses and characterization of new dithiophosphinato zinc complexes

Four known dithiophosphinic acids, DTPA, were synthesized and their zinc complexes were prepared as novelties. The complexes have been proven to have the structures [Zn(µ-DTPAn)2(DTPAn)2], ([DTPAn]= Rn(R)P(S)H, R= 4-CH3O-C6H4-; R1= iso-amyl-, DTPA1; R2= iso-butyl-, DTPA2; R3= sec-butyl-, DTPA3; R4= iso-propyl-, DTPA4). The DTPAs were prepared by the reaction of the Lawesson reagent, [2,4–bis(4-methoxyphenyl)–1,3,2,4–ditiyodifosfetan–2,4–disülfür] (LR), with the corresponding Grignard compounds. The acids formed are viscous liquids difficult to purify and so they were converted to ammonium salts, [DTPAn][NH4], which are easy to obtain as pure crystals. The complexes were identified to have dimeric structures on the basis of mass spectroscopic data