Effects of High-intensity Interval Training Treadmill with Changes in Inclination on TGF-β2 Serum Level of Overweight Male

A third of adults in Indonesia were overweight. Overweight and abdominal obesity also have associations with musculoskeletal disorders, limited respiratory function, and decreased physical function and quality of life, so public health interventions are needed to overcome them. High-Intensity Interval Training (HIIT) has more efficient time and has similar effectiveness as endurance exercise. Transforming Growth Factor-β2 (TGF-β2) is secreted from adipose tissue in response to exercise and improves glucose tolerance. Sixteen overweight subjects who met the study criteria were randomly assigned to the intervention and control groups. The intervention group did HIIT using a treadmill with incline changes for 4 weeks. This research measures weight, body mass index (BMI), waist and hip ratio (WHR), body fat mass, and TGF-β2 serum levels pre- and post-intervention in both groups. There was significant decrease in body fat mass percentage (p=0,002) and WHR (p=0,003) but no significant decrease in weight (p=0.51) and BMI (p=0.526) and no significant increase in TGF-β2 serum levels (p=0.208). However, the control got a significant decrease in TGF-β2 serum levels (p=0.029). Although HIIT for 4 weeks did not increase the TGF-β2 serum levels, it is effective to prevent a significant decrease in TGF-β2 serum levels in overweight men