25 research outputs found
Annulation of Primary Amines to Piperazines and Diazaspirocycles Utilizing α-Methyl Benzyl Resin
No full textSynthesis and Biological Evaluation of 1-Aryl-4, 5-dihydro-1H-pyrazolo[3, 4-d] pyrimidin-4-one Inhibitors of Cyclin- Dependent Kinases
No full text
Tetrahydroxy 10-membered cyclic enediynes
No full textThe preparation of cyclic 10-membered tetrahydroxy enediynes is reported. The synthesis starts from tartaric acid and allows the control of the relative stereochemistry. Acetal protection of the 2,3-hydroxy groups stabilizes the enediyne during synthesis. Removal of the cyclic protecting group with EtSH/TFA transforms the stable compounds into reactive enediynes, and the rate constants of their cyclization were determined in benzene and water. The cytoxicity of the activated compounds was assayed against tumor cells in vitro, but the growth inhibitory effect was weak compared to cisplatin
Cyclic Urea Amides: HIV-1 Protease Inhibitors with Low Nanomolar Potency against both Wild Type and Protease Inhibitor Resistant Mutants of HIV
No full text(6, 7-Dimethoxy-2, 4-dihydroindeno[1, 2-c]pyrazol-3-yl)phenylamines: Receptor Tyrosine Kinase Inhibitors with Broad Antiproliferative Activity against Tumor Cells
No full text
Acidities of Stable Simple Enols and Bond Dissociation Enthalpies of Their H−O Bonds in DMSO
No full text
