News Feature Bicara Karya

“Bicara Karya” as a news feature program created as a new show that can be a source of information and education about the creative industry in the city of Semarang. The program elevates creative industry activities from making, success story, to barriers that occur in a creative industry. Packed with a personal explanation of someone who has expertise in their fields, discussed with a light language but not leaving the essence. In the “Bicara Karya”, The program directors are technically responsible for programming programs both visualizing the manuscript and communicating what they see to the entire production crew (camera person, scriptwriter, voice over, editor, etc.) to realize quality and in accordance with the event's concept and producer's direction. . After going through the pre-production stage, the production process, post production, the work is shown on Cakra Semarang TV every week, starting from 25 April 2017 until 18 July 2017 every Tuesday at 18.00 WIB. Through this work, it is hoped that the public will get educational program to educate and increase the audience information about the creative industry in Semarang and add insight to the viewers. Through the television program "Biacara Karya" which aired on Cakra Semarang TV is a show that raised about the industry keratif, the program director has completed its duties to run for 13 episodes without re-run and certainly not leaving the essence to be conveyed by packing it into an educative and motivating program but not being patronizing

Simple Tracking Output Feedback H ∞ Control for Switched Linear Systems: Lateral Vehicle Control Application

International audienceIn this paper, the problem of the switched H ∞ tracking output feedback control problem is studied. The control design problem is addressed in the context of discrete-time switched linear systems. Then, the design of continuous-time case becomes trivial. Linear Matrix Inequality (LMI) and Linear Matrix Equality (LME) representations are used to express all sufficient conditions to solve the control problem. Some transformations leading to sufficient conditions for the control problem are also used. All conditions are established for any switching using a switched Lyapunov function and a common Lyapunov function. The effectiveness of the proposed control approach is shown through a steering vehicle control implementation. Interesting simulation results are obtained using real data acquired by an instrumented car

Simple Discrete-Time Switched H ∞ Optimal Control: Application for Lateral Vehicle Control

International audienceThis paper presents a switched H ∞ optimal control for a class of discrete-time switched linear systems. All sufficient conditions of the existence of the control law are proved and given in terms of LMI for any switching. Moreover, the proofs are established using an H ∞ norm and switched Lyapunov functions. Its performances are shown through a steering vehicle control application. In fact, the vehicle models are affected by several parameter variations like longitudinal speed, cornering stiffnesses coefficients. The validation step is conducted using real data acquired by a laboratory car under high lateral loads

タンパク質キナーゼAurora-B の新規基質であるSAKI の機能解析研究

博甲第25号生命システム科学博士県立広島大

Augmenting forearm crutches with wireless sensors for lower limb rehabilitation

Forearm crutches are frequently used in the rehabilitation of an injury to the lower limb. The recovery rate is improved if the patient correctly applies a certain fraction of their body weight (specified by a clinician) through the axis of the crutch, referred to as partial weight bearing (PWB). Incorrect weight bearing has been shown to result in an extended recovery period or even cause further damage to the limb. There is currently no minimally invasive tool for long-term monitoring of a patient's PWB in a home environment. This paper describes the research and development of an instrumented forearm crutch that has been developed to wirelessly and autonomously monitor a patient's weight bearing over the full period of their recovery, including its potential use in a home environment. A pair of standard forearm crutches are augmented with low-cost off-the-shelf wireless sensor nodes and electronic components to provide indicative measurements of the applied weight, crutch tilt and hand position on the grip. Data are wirelessly transmitted between crutches and to a remote computer (where they are processed and visualized in LabVIEW), and the patient receives biofeedback by means of an audible signal when they put too much or too little weight through the crutch. The initial results obtained highlight the capability of the instrumented crutch to support physiotherapists and patients in monitoring usage

Histone H3.3 lysine 9 and 27 control repressive chromatin at cryptic enhancers and bivalent promoters

Histone modifications are associated with distinct transcriptional states, but it is unclear whether they instruct gene expression. To investigate this, we mutate histone H3.3 K9 and K27 residues in mouse embryonic stem cells (mESCs). Here, we find that H3.3K9 is essential for controlling specific distal intergenic regions and for proper H3K27me3 deposition at promoters. The H3.3K9A mutation resulted in decreased H3K9me3 at regions encompassing endogenous retroviruses and induced a gain of H3K27ac and nascent transcription. These changes in the chromatin environment unleash cryptic enhancers, resulting in the activation of distinctive transcriptional programs and culminating in protein expression normally restricted to specialized immune cell types. The H3.3K27A mutant disrupts the deposition and spreading of the repressive H3K27me3 mark, particularly impacting bivalent genes with higher basal levels of H3.3 at promoters. Therefore, H3.3K9 and K27 crucially orchestrate repressive chromatin states at cis-regulatory elements and bivalent promoters, respectively, and instruct proper transcription in mESCs

Afecciones vasculares periféricas en pacientes diabéticos

A longitudinal study of Community intervention occurred in the popular Council 12 of Manzanillo, located in the community of San Francisco in order to describe the behavior of peripheral vascular disorders in diabetic patients and to evaluate the effect of the preventive treatment in them. There were chosen 57 patients according to the inclusion and exclusion criteria and there were applied within a period of 2 years: interviews, surveys, questionnaires, and it was performed a guidance strategy for health education and its promotion. Lectures, talks and conferences were developed. The 71.92% of patients had peripheral vascular disorders, the 54.38% were obese, only the 10.52% had a good diabetes education at the beginning of the study. At the end of the study there were obtained changes, increasing the level of knowledge and clinical improvement in patients. The diabetes education classified as good, was about 29.82% as well as the overall improvement of the patients was about 56.09%. We concluded that diabetic patients with the increase in the age presented a greater predisposition to suffer from peripheral vascular conditions. Patients do not have an adequate level of knowledge about their disease, for this reason it is necessary to continue increasing the horizon of knowledge of these patients about their illness and complications.Se realizó un estudio longitudinal, de intervención comunitaria, en el consejo popular 12 de Manzanillo, localizado en la comunidad de San Francisco, para describir el comportamiento de las afecciones vasculares periféricas en los pacientes diabéticos y evaluar el efecto del tratamiento preventivo en los mismos. Se escogieron 57 pacientes que reunían las condiciones según criterio de inclusión y exclusión, se les aplicaron en un período de 2 años: entrevistas, encuestas, cuestionario, y se trazó una estrategia de orientación para la promoción y educación para la salud, se dieron charlas, conversatorios y conferencias. El 71.92% de los pacientes presentaban afecciones vasculares periféricas, el 54.38% eran obesos, solo el 10.52% presentaban una educación diabetológica buena al inicio del estudio. Al final del estudio se lograron cambios, aumentando el nivel de conocimientos y mejoría clínica de los pacientes.  La educación diabetológica clasificada  como buena, fue de un 29.82% así como la mejoría general de los pacientes de un 56.09%. Concluimos que los pacientes diabéticos con el aumento de la edad presentaron una mayor predisposición a padecer afecciones vasculares periféricas.  Los pacientes no poseen un adecuado  nivel de conocimiento sobre su enfermedad por lo que se plantea la necesidad de continuar aumentando el horizonte de conocimientos de estos pacientes acerca de su enfermedad y las complicaciones

Functional Recovery and Serum Angiogenin Changes According to Intensity of Rehabilitation Therapy After Stroke

Rehabilitation is still the only treatment available to improve functional status after the acute phase of stroke. Most clinical guidelines highlight the need to design rehabilitation treatments considering starting time, intensity, and frequency, according to the tolerance of the patient. However, there are no homogeneous protocols and the biological effects are under investigation. To investigate the impact of rehabilitation intensity (hours) after stroke on functional improvement and serum angiogenin (ANG) in a 6-month follow-up study. A prospective, observational, longitudinal, and multicenter study with three cohorts: strokes in intensive rehabilitation therapy (IRT, minimum 15 h/week) vs. conventional therapy (NO-IRT, <15 h/week), and controls subjects (without known neurological, malignant, or inflammatory diseases). A total of seven centers participated, with functional evaluations and blood sampling during follow-up. The final cohort includes 62 strokes and 43 controls with demographic, clinical, blood samples, and exhaustive functional monitoring. The median (IQR) number of weekly hours of therapy was different: IRT 15 (15-16) vs. NO-IRT 7.5 (5-9), p < 0.01, with progressive and significant improvements in both groups. However, IRT patients showed earlier improvements (within 1 month) on several scales (CAHAI, FMA, and FAC; p < 0.001) and the earliest community ambulation achievements (0.89 m/s at 3 months). There was a significant difference in ANG temporal profile between the IRT and NO-IRT groups (p < 0.01). Additionally, ANG was elevated at 1 month only in the IRT group (p < 0.05) whereas it decreased in the NO-IRT group (p < 0.05). Our results suggest an association of rehabilitation intensity with early functional improvements, and connect the rehabilitation process with blood biomarkers

Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20128-w