2 research outputs found
Impact of colorectal cancer screening on cancer-specific mortality in Europe: A systematic review
Background: Populations differ with respect to their cancer risk and screening preferences, which may influence the performance of colorectal cancer (CRC) screening programs. This review aims to
Development and Validation of Three Regional Microsimulation Models for Predicting Colorectal Cancer Screening Benefits in Europe
Background. Validated microsimulation models have been shown to be useful tools in providing support for colorec-
tal cancer (CRC) screening decisions. Aiming to assist European countries in reducing CRC mortality, we developed
and validated three regional models for evaluating CRC screening in Europe. Methods. Microsimulation Screening
Analysis–Colon (MISCAN-Colon) model versions for Italy, Slovenia, and Finland were quantified using data from
different national institutions. These models were validated against the best available evidence for the effectiveness of
screening from their region (when available): the Screening for COlon REctum (SCORE) trial and the Florentine
fecal immunochemical test (FIT) screening study for Italy; the Norwegian Colorectal Cancer Prevention
(NORCCAP) trial and the guaiac fecal occult blood test (gFOBT) Finnish population-based study for Finland.
When published evidenc