9 research outputs found

    Enhancement of bone marrow toxicity of VM-26-CCNU combination by bleomycin

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    This paper reports an unexpected and severe toxic effect, wbc count depression, observed in patients treated with VM-26, CCNU, and BLM. Such toxicity was not present in a similar group of patients treated with only VM-26 plus CCNU.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

    Probable hypersensitivity reaction to vancomycin associating rash, fever and neutropenia.

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    We describe the case of a 54-year old woman with breast cancer who was treated by vancomycin for febrile neutropenia due to a methicillin-resistant Staphyloccocus epidermidis infection of a surgically implanted catheter. She developed an hypersensitivity reaction to vancomycin associating neutropenia, fever, skin rash and elevated liver enzymes following re-challenge with vancomycin after having been misdiagnosed with septic thrombophlebitis. Following this re-challenge, neutrophils count fell dramatically but promptly resolved after cessation of vancomycin.Case ReportsJournal ArticleSCOPUS: ar.jinfo:eu-repo/semantics/publishe

    Natural killer-like T-cell lymphoma of the stomach

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    We report the case of a 69-year-old white woman who developed a natural killer (NK)-like T-cell lymphoma involving primarily the stomach. The tumour consisted of large and pleomorphic lymphocytes infiltrating the gastric mucosa. Immunohistochemistry performed on paraffin sections showed the neoplastic cells to be CD3+, CD5-, CD8-, CD43+, CD45RO+, and CD57+. In addition, these cells also expressed HLA-DR, granzyme B, and, to a lesser extent, the CD30 activation marker. No pathologic features suggesting Helicobacter pylori, Epstein-Barr virus infection, or lymphocytic gastritis were found within adjacent normal mucosa. The patient had no previous history of coeliac disease, and her serology for H. pylori was negative. Since lymphomas are usually considered the neoplastic counterpart of normal lymphocytic subsets, it is possible that in this case the tumour cells originate from a distinct cytotoxic T-cell population normally present within the gastric mucosa. The pathogenesis of this highly unusual neoplasm, however, remains a mystery.SCOPUS: ar.jinfo:eu-repo/semantics/publishe
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