Clonal expansion of Staphylococcus epidermidis strains causing Hickman catheter-related infections in a hemato-oncologic department

The detailed analysis of 411 strains of coagulase-negative staphylococci (CoNS) obtained from 40 neutropenic hemato-oncologic patients (61 Hickman catheter episodes) on intensive chemotherapy is described. By random amplification of polymorphic DNA (RAPD) analysis, a total of 88 different genotypes were detected: 51 in air samples and 30 in skin cultures prior to insertion, 12 in blood cultures after insertion, and only 5 involved in catheter-related infections (CRI). Two RAPD genotypes of Staphylococcus epidermidis predominated, and their prevalence increased during patient hospitalization. At insertion, these clones constituted 11 of 86 (13%) CoNS isolated from air samples and 33 of 75 (44%) CoNS isolated from skin cultures. After inser

Distinctive Cytokines as Biomarkers Predicting Fatal Outcome of Severe Staphylococcus aureus Bacteremia in Mice

Invasive Staphylococcus aureus infections are frequently associated with bacteraemia. To support clinical decisions on antibiotic therapy, there is an urgent need for reliable markers as predictors of infection outcome. In the present study in mice, bacteraemia was established by intravenous inoculation of a clinical S. aureus isolate at the LD50 inoculum. As potential biomarkers for fatal outcome, blood culture (qualitative and quantitative), serum levels of C-reactive protein (CRP), as well as 31 selected cytokines and chemokines were assessed during the first three days of infection. A positive S. aureus blood culture, the quantitative blood culture, CRP levels, and levels of eight cytokines were indicative for the presence of S. aureus bacteraemia. However, only tumor necrosis factor (TNF) α, interleukin (IL) 1α, and keratinocyte chemoattractant (KC; a functional homologue of human IL-8) were each significantly elevated in eventually non-surviving infected mice versus eventually surviving infected mice. In severe S. aureus bacteraemia in mice, TNF-α, IL-1α, and KC are biomarkers predicting fatal outcome of infection. KC was a biomarker elevated irrespective the progression of infection, which is very interesting regarding clinical application in view of the heterogeneity of patients experiencing bacteraemia in this respect

The Road to peace

Yogyakarta362 p.; 21 cm

Love in a fearful land : Kasih di sebuah negeri yang menakutkan

Malang190 p.; 20 cm

Menggapai Kematangan Hidup Rohani

Yogyakarta159 hal.; 21 c

journeys of the heart

1 (out of 3) audio cassettes (1 hr. 32 min.)Title based on the contents of the item. ; Previously item number Oversize II. ; Catalogue number GB92.29. ; See Calendar files series for more information about this event - file 1095, box 197. ; Digitized February 14, 2011.For more information please contact Special Collections, the University of St. Michael's College.Item consists of three audio cassettes of talks Nouwen gave at the 1992 Greenbelt Festival, St. Lukes Hillmarton Rd. London, England. SR107 v1: "The Life of the Beloved"; SR107 v2: "The Discipline of the Beloved"; SR107 v3: "Being the Beloved"

With open hands

India158 p.; 21 cm

Walk with Jesus. : stations of the cross.

New Yorkx, 98 p.; 21 cm

Reaching Out : The Three Movements of the Spiritual Life

Garden City120 p.; 21 c

Out of solitude. : Three meditations on the christian life.

India63 p.; 19 cm