Gated metabolic myocardial imaging, a surrogate for dual perfusion-metabolism imaging by positron emission tomography

Acknowledgments The authors are grateful for the help from Dr H Ali and Dr A Dawson. Funding: This study was performed using a research grant from the Aberdeen Royal Hospitals Trust's Endowment Fund, with further support from the Department of Medical Physics at the University of Aberdeen, for which the authors express their gratitude.Peer reviewedPublisher PD

Microenvironmental regulation of metastasis

Metastasis is a multistage process that requires cancer cells to escape from the primary tumour, survive in the circulation, seed at distant sites and grow. Each of these processes involves rate-limiting steps that are influenced by non-malignant cells of the tumour microenvironment. Many of these cells are derived from the bone marrow, particularly the myeloid lineage, and are recruited by cancer cells to enhance their survival, growth, invasion and dissemination. This Review describes experimental data demonstrating the role of the microenvironment in metastasis, identifies areas for future research and suggests possible new therapeutic avenues

Sustainability and the rural economy:an evolutionary perspective

Abstract. The authors define the rural economy not as a functional entity but as a complex, open system, the analysis of which requires an interdisciplinary approach oriented to the study of processes and interactions. This evolutionary perspective is illustrated by two generic studies of rural issues: the role played by the postwar planning regime in the definition and management of rural space in Britain; and the connection between agricultural development and the repro-duction of farm structures. The understanding of sustainable development which emerges calls for a holistic and responsive approach to rural policy formulation

Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumor

10.1371/journal.pbio.1001162PLoS Biology99-PBLI