Pharmacological HIF-1 activation upregulates extracellular vesicle production synergistically with adiponectin through transcriptional induction and protein stabilization of T-cadherin

Fujii K., Fujishima Y., Kita S., et al. Pharmacological HIF-1 activation upregulates extracellular vesicle production synergistically with adiponectin through transcriptional induction and protein stabilization of T-cadherin. Scientific Reports 14, 3620 (2024); https://doi.org/10.1038/s41598-024-51935-6.Pharmacological activation of hypoxia-inducible factor 1 (HIF-1), a hypoxia-responsive transcription factor, has attracted increasing attention due to its efficacy not only in renal anemia but also in various disease models. Our study demonstrated that a HIF-1 activator enhanced extracellular vesicle (EV) production from cultured endothelial cells synergistically with adiponectin, an adipocyte-derived factor, through both transcriptional induction and posttranscriptional stabilization of an adiponectin binding partner, T-cadherin. Increased EV levels were observed in wild-type mice but not in T-cadherin null mice after consecutive administration of roxadustat. Adiponectin- and T-cadherin-dependent increased EV production may be involved in the pleiotropic effects of HIF-1 activators

Plasma xanthine oxidoreductase activity in Japanese patients with type 2 diabetes across hospitalized treatment

Yusuke Kawachi; Yuya Fujishima; Hitoshi Nishizawa; Hirofumi Nagao; Takashi Nakamura; Seigo Akari; Takayo Murase; Naohiro Taya; Kazuo Omori; Akimitsu Miyake; Shiro Fukuda; Mitsuyoshi Takahara; Shunbun Kita; Naoto Katakami; Norikazu Maeda; Iichiro Shimomura. Plasma xanthine oxidoreductase activity in Japanese patients with type 2 diabetes across hospitalized treatment. J Diabetes Investig. 2020

Compactive Viscosity of Snow and Its Climatic Implications at Mizuho Station, Antarctica (Special Issue of the Proceedings of the First Symposium on Antarctic Meteorology and Glaciology)

The compactive viscosity coefficient of snow was obtained from a density profile at Mizuho Station, Antarctica The value of the compactive viscosity coefficient was by two orders of magnitude larger than that of ordinary seasonal snow. The large value was attributed to strong bonds between constituent ice particles within Antarctic snow which had been aged for prolonged periods A sharp peak of the compactive viscosity coefficient was found in a limited range of the depth around 35 m, that is in a range of the density around 750 kg m^ In the depth range from 30 m to 40 m the layer-to-layer densities varied largely and the mean density deviated markedly from a smoothed general trend. These results suggest that a colder climate occurred repeatedly and lasted approximately 300 years before the present in the vicinity of Mizuho Statio

Changes in Body Weight in Severely Obese Patients Treated with the Anorexiant Mazindol

(1) Background: The number of severely obese patients worldwide is rapidly increasing. Recently, novel therapeutic approaches, such as bariatric surgery or GLP-1 receptor agonists, have emerged, bringing about a paradigm shift in this field. However, these therapies sometimes face challenges, such as peri-surgical complications or supply shortages. Mazindol, which is an appetite suppressant approved decades ago in Japan, remains a valuable option. In this study, we investigated the effectiveness of mazindol in reducing body weight in 147 patients, and we examined the factors influencing said effectiveness. (2) Methods: The patients were divided into four groups based on the treatment cycles they underwent: 1 cycle, 2 cycles, 3–5 cycles, and over 6 cycles. We compared the changes in body weight before and after the treatment among these four groups. Additionally, we sought to identify the factors correlated to the effectiveness of mazindol. (3) Results: The change in body weight was more pronounced in the group which underwent 3–5 cycles compared to the groups which underwent 1 cycle and 2 cycles; this change was also more pronounced in the group which underwent over 6 cycles compared to those which underwent 1 cycle. Furthermore, we observed a significant correlation between the initial body weight and the extent of body weight change. (4) Conclusions: Mazindol demonstrated effectiveness in reducing the body weight of patients in a cycle-dependent manner

ユキ ノ アッシュク ネンセイ ト ソノ キコウガクテキ イミ ダイ1カイ ナンキョク キスイケン シンポジウム

日本南極地域観測隊か得た,みずほ基地の雪の密度のデータ数は,第11次,第12次および第13次のものを合計すると3635にのぼる.これらの測定結果を吟味,整理したものを使って「圧縮粘性係数」の深さ分布が求められた.みずほ基地の雪に限らず,一般に極地の雪の圧縮粘性係数は,季節的積雪,たとえば北海道の雪に比べて約100倍大きい.これは,極地における長期間の圧密過程において,氷粒子間の結合が極度に成長したためと解釈されるみずほ基地の雪において,密度の測定値は,深さ約30m～40mの領域で,大きく振動し,かつ平均的傾向曲線からはずれた.圧縮粘性係数は,この深さ領域で鋭い極大を示した.これらの結果は,この層の雪が蓄積した時,年間蓄積量の少ない寒冷な時期が繰返しかつ持続して襲来したことを示唆する.その時期は,雪の年間蓄積量から約300年前と推定される.The compactive viscosity coefficient of snow was obtained from a density profile at Mizuho Station, Antarctica The value of the compactive viscosity coefficient was by two orders of magnitude larger than that of ordinary seasonal snow. The large value was attributed to strong bonds between constituent ice particles within Antarctic snow which had been aged for prolonged periods A sharp peak of the compactive viscosity coefficient was found in a limited range of the depth around 35 m, that is in a range of the density around 750 kg m^ In the depth range from 30 m to 40 m the layer-to-layer densities varied largely and the mean density deviated markedly from a smoothed general trend. These results suggest that a colder climate occurred repeatedly and lasted approximately 300 years before the present in the vicinity of Mizuho Statio