Some New Constructors for Minimal Circular Partially Balanced Neighbor Designs

Minimal circular neighbor designsa are economical to minimize the bias due to neighbor effects for v odd. For v even, minimal circular partially balanced neighbor designs (MCPBNDs) are used. Generators to obtain MCPBNDs-II in equal, two and three different blocks sizes are available in literature for c = 0 and 1, where c is remainder if m is divided by 4, m = (v − 2)/2 and v is number of treatments. These designs have not been constructed for c = 2 and 3. To complete the construction of this class of neighbor designs, MCPBNDs-II are, therefore, constructed for the remaining cases. MCPNBDs-II are the neighbor designs in which 3v/2 pairs of different treatments do not appear as neighbors

Work-Family and Family-Work Conflict among Elementary School Teachers in Pakistan

 The study was aimed to investigate thework-family and family-work conflict among elementary school teachers of Sheikhupuradistrict in Pakistan. Study was descriptive in nature. All the public elementary school teachers of Sheikhupura were considered the population. A sample of 886 ESTs was selected through simple random sampling technique. The 550 ESTs (males =185 and females= 385) had responded.A self-developed questionnaire was used to collect data by the researcher. The questionnaire was divided into two sub-dimensions as work-to-family conflict and family-to-work conflict. Reliability value for the sub-dimensions of work-to-family conflict (α=.81) and family-to-work conflict (α=.87) was good. Results revealed that the elementary school teachers were experiencing work-family conflict at moderate level. Elementary school teachers were experiencing more work-family conflict than the family-work conflict. A significant difference found in the level of work-family and family-work conflict between male and female elementary school teachers. It was shown that female ESTs were facing more work-to-family and family-to-work conflict than male ESTs.&nbsp

Human linker histones: interplay between phosphorylation and O-β-GlcNAc to mediate chromatin structural modifications

Eukaryotic chromatin is a combination of DNA and histone proteins. It is established fact that epigenetic mechanisms are associated with DNA and histones. Initial studies emphasize on core histones association with DNA, however later studies prove the importance of linker histone H1 epigenetic. There are many types of linker histone H1 found in mammals. These subtypes are cell specific and their amount in different types of cells varies as the cell functions. Many types of post-translational modifications which occur on different residues in each subtype of linker histone H1 induce conformational changes and allow the different subtypes of linker histone H1 to interact with chromatin at different stages during cell cycle which results in the regulation of transcription and gene expression. Proposed O-glycosylation of linker histone H1 promotes condensation of chromatin while phosphorylation of linker histone H1 is known to activate transcription and gene regulation by decondensation of chromatin. Interplay between phosphorylation and O-β-GlcNAc modification on Ser and Thr residues in each subtype of linker histone H1 in Homo sapiens during cell cycle may result in diverse functional regulation of proteins. This in silico study describes the potential phosphorylation, o-glycosylation and their possible interplay sites on conserved Ser/Thr residues in various subtypes of linker histone H1 in Homo sapiens

A Generalized Class of Circular Designs Strongly Balanced for Neighbor Effects

Minimal strongly balanced neighbor designs are useful (i) to minimize the bias due to neighbor effects economically, and (ii) to estimate the direct effect and neighbor effects independently. Such designs can easily be obtained for v odd and are available in literature. In this article, A generalized class of minimal circular designs strongly balanced for neighbor effects in blocks of equal and two different sizes have been constructed in which only v/2 unordered pairs of treatments do not appear as neighbors, where v is the number of treatments

Some New Constructors of Circular Strongly Generalized Neighbor Designs

Minimal strongly balanced neighbor designs are well known designs to balance the neighbor effects at low cost as well as to estimate the direct effects and neighbor effects independently for v odd, where v is number of treatments to be compared. Minimal strongly generalized neighbor designs are used to minimize the bias due to neighbor effects for v even. In this article, constructors are developed to construct two useful classes of minimal circular strongly generalized neighbor designs

Medical students’ attitudes towards the clinical importance of embryology

Objective of study: The objective of the study is to identify the attitudes of medical students towards the clinical importance of embryology. Methodology: The cross-sectional questionnaire-based survey was conducted at a private medical college of Sialkot, Islam Medical College from September 2019 to November 2019. Ethical approval was obtained from the Institutional Research and Ethics Committee prior to the study. Hundred First year and 100 final year medical students of Islam Medical College, participated in the survey. Thurdstone and Chave attitude analysis scoring was used to assess the attitudes.  The questionnaire consisted of 20 statements. Students had to tick only those statements with which they were in full agreement. Prior to conducting the study a median score was taken out of 50 anatomy teachers, showing their opinion toward each statement. Results: The results of the study showed that the medical students do appreciate the importance of embryology in the early years and to a more extent in the clinical years. The attitude scores remained on the positive side. Female students showed better attitudes towards embryology in both years. Conclusion:  To understand the importance of embryology efforts are required by the teachers teaching anatomy, and medical educationalists, to inform medical students of the relevance of embryology in attaining clinical competence. Key words: Attitude, Clinical, Embryology, Continuous..

New generators for minimal circular generalised neighbour designs in blocks of two different sizes

Minimal neighbour designs (NDs) are used when a response of a treatment (direct effect) is affected by the treatment(s) applied in the neighbouring units. Minimal generalised NDs are preferred when minimal NDs cannot be constructed. Through the method of cyclic shifts (Rule I), the conditions for the existence of minimal circular generalised NDs are discussed, in which v/2 unordered pairs do not appear as neighbours. Certain generators are also developed to obtain minimal circular generalised NDs in blocks of two different sizes, where k2 = 3, 4 and 5. All these designs are constructed using i sets of shifts for k1 and two for k2

An Algorithm Coded with R to Generate GN2 -designs in Circular Blocks

Minimal neighbor balanced designs are economical, therefore, these are preferred by the experimenters to minimize the bias due to neighbor effects. Minimal circular balanced neighbor designs cannot be constructed for almost every case of v even, where v is number of the treatments to be compared. For v even, the circular GN2-designs in which each treatment appears exactly once as neighbors with all other treatments except the one with which it appears twice, are considered the better alternate to the minimal balanced neighbor designs. In this article, an algorithm is developed to generate the circular GN2-designs for v even which can be converted directly into minimal circular balanced and strongly balanced neighbor designs. This algorithm is also coded with R

Serine 204 phosphorylation and O-<it>β</it>-GlcNAC interplay of IGFBP-6 as therapeutic indicator to regulate IGF-II functions in viral mediated hepatocellular carcinoma

Abstract Hepatocellular carcinoma is mainly associated with viral hepatitis B and C. Activation of cell growth stimulator IGF-II gene is observed in tumor formation especially in viral associated hepatocellular carcinoma. Elevated IGF-II levels are indicator of increased risk for cholangiocellular and hepatocellular carcinomas through over saturation of IGF-II binding capacities with IGF receptors leading to cellular dedifferentiation. In HCV, core protein is believed to trans-activate host IGF-II receptor through PKC pathway and the inhibition of tumor cell growth can be achieved by blocking IGF-II pathway either at transcriptional level or increasing its binding with IGFBPs (Insulin like growth factor proteins) at C-terminal, so that it is not available in free form. IGFBP-6 is a specific inhibitor of IGF-II actions. Affinity of IGFBPs with IGFs is controlled by post-translational modifications. Phosphorylation of IGFBPs inhibits IGFs action on target cells while O-glycosylation prevents binding of IGFBP-6 to glycosaminoglycans and cell membranes and resulting in a 10-fold higher affinity for IGF-II. O-glycosylation and phosphorylation operate the functional expression of cellular proteins, this switching on and off the protein expression is difficult to monitor in vivo. By using neural network based prediction methods, we propose that alternate O-β-GlcNAc modification and phosphorylation on Ser 204 control the binding of IGFBP-6 with IGF-II. This information may be used for developing new therapies by regulating IGFBP-6 assembly with IGF-II to minimize the risk of viral associated hepatocellular carcinoma. We can conclude that during HCV/HBV infection, O-β-GlcNAc of IGFBP-6 at Ser 204 diminish their binding with IGF-II, increase IGF-II cellular expression and promote cancer progression which can lead to hepatocellular carcinoma. Furthermore, this site can be used for developing new therapies to control the IGF-II actions during viral infection to minimize the risk of hepatocellular carcinoma.</p