Push and pull forces and migration in Vietnam

This paper adopts the push and pull model of migration to explain inter-provincial migration flows across 63 provinces or cities of Vietnam in the period 2004-2009. We used a solution to a quadratic cost migration problem by combining the total number of in and out-migration of various provinces and inverse distances between provinces that aims at calculating the push and pull factors of each province. The result confirms the hypothesis that push factors correlate well with total out flows of provinces and pull factors with total inflows of provinces. In addition, it is found that pull and push factors are explained rather well by population size and income, but not so by urbanization and povert

Push and pull forces and migration in Vietnam

This paper adopts the push and pull model of migration to explain inter-provincial migration flows across 63 provinces or cities of Vietnam in the period 2004-2009. We used a solution to a quadratic cost migration problem by combining the total number of in and out-migration of various provinces and inverse distances between provinces that aims at calculating the push and pull factors of each province. The result confirms the hypothesis that push factors correlate well with total out flows of provinces and pull factors with total inflows of provinces. In addition, it is found that pull and push factors are explained rather well by population size and income, but not so by urbanization and povert

Novel potent liposome agonists of triggering receptor expressed on myeloid cells 2 phenocopy antibody treatment in cells

The receptor Triggering Receptor Expressed on Myeloid cells 2 (TREM2) is associated with several neurodegenerative diseases including Alzheimer's Disease and TREM2 stimulation represents a novel therapeutic opportunity. TREM2 can be activated by antibodies targeting the stalk region, most likely through receptor dimerization. Endogenous ligands of TREM2 are suggested to be negatively charged apoptotic bodies, mimicked by phosphatidylserine incorporated in liposomes and other polyanionic molecules likely binding to TREM2 IgV fold. However, there has been much discrepancy in the literature on the nature of phospholipids (PLs) that can activate TREM2 and on the stability of the corresponding liposomes over time. We describe optimized liposomes as robust agonists selective for TREM2 over TREM1 in cellular system. The detailed structure/activity relationship studies of lipid polar heads indicate that negatively charged lipid heads are required for activity and we identified the shortest maximally active PL sidechain. Optimized liposomes are active on both TREM2 common variant and TREM2 R47H mutant. Activity and selectivity were further confirmed in different native TREM2 expressing cell types including on integrated cellular responses such as stimulation of phagocytic activity. Such tool agonists will be useful in further studies of TREM2 biology in cellular systems alongside antibodies, and in the design of small molecule synthetic TREM2 agonists