Assessing the growing impact and potential of social networking mediums in crisis communication in South Africa : A Case Study of the South African Protection of State Information Bill

Includes bibliography.With new political developments breeding opportunities for crises, proliferation of new media types increasing exposure to crises, there is a growing awareness of the potential, influence, impact and capabilities of social media. Focusing on South Africa's Secrecy Bill, a crisis with implications on access to information and media freedom, this study provides a discussion of the dynamics of crisis communication online. By undertaking an analysis of the uses of social media during deliberations of the Secrecy Bill and its implications, the study sought to explore how young South Africans have embraced social media as a communication tool. An examination of the literature reveals that younger generations are frequent bloggers and users of Twitter, a popular social media site. Focusing on these two platforms, through a qualitative content analysis, findings show that their contribution to deliberations was mainly to make sense of the crisis and distribute relevant materials relating to the debate

The effectiveness of an animation on Grade 10 learners’ understanding of Mitosis in Tembisa, South Africa

Science education has seen an increase in the use of computer-based models for improving learners‘ conceptual understanding. However, the effectiveness of these models remains a subject for much debate, particularly given the multiple factors that affect learning. There is also a dearth of research regarding the effectiveness of these in previously-disadvantaged school contexts where access to computer-based infrastructure is minimal. Countries such as South Africa are currently adopting teaching methods that integrate information technology. This includes the distribution of smart boards, mobile computers, and tablets in school to support teaching and learning. The extent to which these resources have a positive impact on learning is a subject of ongoing research. In addition, researchers are still exploring the role that computer-based teaching could have on learners in light of a relatively poor socio-economic context. In light of the increasing use of computer-based teaching in South African schools, the primary purpose of the current research was to investigate the effectiveness of virtual realities such as computer-based animations on students‘ content understanding in Life Sciences. This research, conducted as a mixed-method approach in a High school in Tembisa, outside of Johannesburg in South Africa, involved Grade 10 Life Science learners (n = 67). These learners were selected using non-random purposive sampling. A quasi experimental design was adopted in which traditional textbook-based teaching was used to teach mitosis, while the experimental group was taught using an animation. Pre- and post-test learner performances were then compared within and between groups. Interviews were also conducted to determine potential learning difficulties associated with the use of the animation. Results indicated that learners‘ performance improved when being taught through an animation. Results also reflected that some learners experienced learning difficulties when using the animation. The integration of sounds and pictures on the animation was shown to assist learners create visual mental models. Learners were able to build their own mental model based on the observations and accompanying sound. Results also demonstrated that visual information presented through the animation is retained in the memory structure for a longer period and learners were encouraged to develop an understanding of learnt concepts and support their memory retention which improved their achievement in the post-intervention test.Science and Technology EducationM. Ed. (Natural Science Education

Dolutegravir twice-daily dosing in children with HIV-associated tuberculosis: a pharmacokinetic and safety study within the open-label, multicentre, randomised, non-inferiority ODYSSEY trial

Background: Children with HIV-associated tuberculosis (TB) have few antiretroviral therapy (ART) options. We aimed to evaluate the safety and pharmacokinetics of dolutegravir twice-daily dosing in children receiving rifampicin for HIV-associated TB. Methods: We nested a two-period, fixed-order pharmacokinetic substudy within the open-label, multicentre, randomised, controlled, non-inferiority ODYSSEY trial at research centres in South Africa, Uganda, and Zimbabwe. Children (aged 4 weeks to <18 years) with HIV-associated TB who were receiving rifampicin and twice-daily dolutegravir were eligible for inclusion. We did a 12-h pharmacokinetic profile on rifampicin and twice-daily dolutegravir and a 24-h profile on once-daily dolutegravir. Geometric mean ratios for trough plasma concentration (Ctrough), area under the plasma concentration time curve from 0 h to 24 h after dosing (AUC0–24 h), and maximum plasma concentration (Cmax) were used to compare dolutegravir concentrations between substudy days. We assessed rifampicin Cmax on the first substudy day. All children within ODYSSEY with HIV-associated TB who received rifampicin and twice-daily dolutegravir were included in the safety analysis. We described adverse events reported from starting twice-daily dolutegravir to 30 days after returning to once-daily dolutegravir. This trial is registered with ClinicalTrials.gov (NCT02259127), EudraCT (2014–002632-14), and the ISRCTN registry (ISRCTN91737921). Findings: Between Sept 20, 2016, and June 28, 2021, 37 children with HIV-associated TB (median age 11·9 years [range 0·4–17·6], 19 [51%] were female and 18 [49%] were male, 36 [97%] in Africa and one [3%] in Thailand) received rifampicin with twice-daily dolutegravir and were included in the safety analysis. 20 (54%) of 37 children enrolled in the pharmacokinetic substudy, 14 of whom contributed at least one evaluable pharmacokinetic curve for dolutegravir, including 12 who had within-participant comparisons. Geometric mean ratios for rifampicin and twice-daily dolutegravir versus once-daily dolutegravir were 1·51 (90% CI 1·08–2·11) for Ctrough, 1·23 (0·99–1·53) for AUC0–24 h, and 0·94 (0·76–1·16) for Cmax. Individual dolutegravir Ctrough concentrations were higher than the 90% effective concentration (ie, 0·32 mg/L) in all children receiving rifampicin and twice-daily dolutegravir. Of 18 children with evaluable rifampicin concentrations, 15 (83%) had a Cmax of less than the optimal target concentration of 8 mg/L. Rifampicin geometric mean Cmax was 5·1 mg/L (coefficient of variation 71%). During a median follow-up of 31 weeks (IQR 30–40), 15 grade 3 or higher adverse events occurred among 11 (30%) of 37 children, ten serious adverse events occurred among eight (22%) children, including two deaths (one tuberculosis-related death, one death due to traumatic injury); no adverse events, including deaths, were considered related to dolutegravir. Interpretation: Twice-daily dolutegravir was shown to be safe and sufficient to overcome the rifampicin enzyme-inducing effect in children, and could provide a practical ART option for children with HIV-associated TB

Neuropsychiatric manifestations and sleep disturbances with dolutegravir-based antiretroviral therapy versus standard of care in children and adolescents: a secondary analysis of the ODYSSEY trial

BACKGROUND: Cohort studies in adults with HIV showed that dolutegravir was associated with neuropsychiatric adverse events and sleep problems, yet data are scarce in children and adolescents. We aimed to evaluate neuropsychiatric manifestations in children and adolescents treated with dolutegravir-based treatment versus alternative antiretroviral therapy. METHODS: This is a secondary analysis of ODYSSEY, an open-label, multicentre, randomised, non-inferiority trial, in which adolescents and children initiating first-line or second-line antiretroviral therapy were randomly assigned 1:1 to dolutegravir-based treatment or standard-of-care treatment. We assessed neuropsychiatric adverse events (reported by clinicians) and responses to the mood and sleep questionnaires (reported by the participant or their carer) in both groups. We compared the proportions of patients with neuropsychiatric adverse events (neurological, psychiatric, and total), time to first neuropsychiatric adverse event, and participant-reported responses to questionnaires capturing issues with mood, suicidal thoughts, and sleep problems. FINDINGS: Between Sept 20, 2016, and June 22, 2018, 707 participants were enrolled, of whom 345 (49%) were female and 362 (51%) were male, and 623 (88%) were Black-African. Of 707 participants, 350 (50%) were randomly assigned to dolutegravir-based antiretroviral therapy and 357 (50%) to non-dolutegravir-based standard-of-care. 311 (44%) of 707 participants started first-line antiretroviral therapy (ODYSSEY-A; 145 [92%] of 157 participants had efavirenz-based therapy in the standard-of-care group), and 396 (56%) of 707 started second-line therapy (ODYSSEY-B; 195 [98%] of 200 had protease inhibitor-based therapy in the standard-of-care group). During follow-up (median 142 weeks, IQR 124–159), 23 participants had 31 neuropsychiatric adverse events (15 in the dolutegravir group and eight in the standard-of-care group; difference in proportion of participants with ≥1 event p=0·13). 11 participants had one or more neurological events (six and five; p=0·74) and 14 participants had one or more psychiatric events (ten and four; p=0·097). Among 14 participants with psychiatric events, eight participants in the dolutegravir group and four in standard-of-care group had suicidal ideation or behaviour. More participants in the dolutegravir group than the standard-of-care group reported symptoms of self-harm (eight vs one; p=0·025), life not worth living (17 vs five; p=0·0091), or suicidal thoughts (13 vs none; p=0·0006) at one or more follow-up visits. Most reports were transient. There were no differences by treatment group in low mood or feeling sad, problems concentrating, feeling worried or feeling angry or aggressive, sleep problems, or sleep quality. INTERPRETATION: The numbers of neuropsychiatric adverse events and reported neuropsychiatric symptoms were low. However, numerically more participants had psychiatric events and reported suicidality ideation in the dolutegravir group than the standard-of-care group. These differences should be interpreted with caution in an open-label trial. Clinicians and policy makers should consider including suicidality screening of children or adolescents receiving dolutegravir

Independent and combined effects of improved water, sanitation, and hygiene, and improved complementary feeding, on child stunting and anaemia in rural Zimbabwe: a cluster-randomised trial.

BACKGROUND: Child stunting reduces survival and impairs neurodevelopment. We tested the independent and combined effects of improved water, sanitation, and hygiene (WASH), and improved infant and young child feeding (IYCF) on stunting and anaemia in in Zimbabwe. METHODS: We did a cluster-randomised, community-based, 2 × 2 factorial trial in two rural districts in Zimbabwe. Clusters were defined as the catchment area of between one and four village health workers employed by the Zimbabwe Ministry of Health and Child Care. Women were eligible for inclusion if they permanently lived in clusters and were confirmed pregnant. Clusters were randomly assigned (1:1:1:1) to standard of care (52 clusters), IYCF (20 g of a small-quantity lipid-based nutrient supplement per day from age 6 to 18 months plus complementary feeding counselling; 53 clusters), WASH (construction of a ventilated improved pit latrine, provision of two handwashing stations, liquid soap, chlorine, and play space plus hygiene counselling; 53 clusters), or IYCF plus WASH (53 clusters). A constrained randomisation technique was used to achieve balance across the groups for 14 variables related to geography, demography, water access, and community-level sanitation coverage. Masking of participants and fieldworkers was not possible. The primary outcomes were infant length-for-age Z score and haemoglobin concentrations at 18 months of age among children born to mothers who were HIV negative during pregnancy. These outcomes were analysed in the intention-to-treat population. We estimated the effects of the interventions by comparing the two IYCF groups with the two non-IYCF groups and the two WASH groups with the two non-WASH groups, except for outcomes that had an important statistical interaction between the interventions. This trial is registered with ClinicalTrials.gov, number NCT01824940. FINDINGS: Between Nov 22, 2012, and March 27, 2015, 5280 pregnant women were enrolled from 211 clusters. 3686 children born to HIV-negative mothers were assessed at age 18 months (884 in the standard of care group from 52 clusters, 893 in the IYCF group from 53 clusters, 918 in the WASH group from 53 clusters, and 991 in the IYCF plus WASH group from 51 clusters). In the IYCF intervention groups, the mean length-for-age Z score was 0·16 (95% CI 0·08-0·23) higher and the mean haemoglobin concentration was 2·03 g/L (1·28-2·79) higher than those in the non-IYCF intervention groups. The IYCF intervention reduced the number of stunted children from 620 (35%) of 1792 to 514 (27%) of 1879, and the number of children with anaemia from 245 (13·9%) of 1759 to 193 (10·5%) of 1845. The WASH intervention had no effect on either primary outcome. Neither intervention reduced the prevalence of diarrhoea at 12 or 18 months. No trial-related serious adverse events, and only three trial-related adverse events, were reported. INTERPRETATION: Household-level elementary WASH interventions implemented in rural areas in low-income countries are unlikely to reduce stunting or anaemia and might not reduce diarrhoea. Implementation of these WASH interventions in combination with IYCF interventions is unlikely to reduce stunting or anaemia more than implementation of IYCF alone. FUNDING: Bill & Melinda Gates Foundation, UK Department for International Development, Wellcome Trust, Swiss Development Cooperation, UNICEF, and US National Institutes of Health.The SHINE trial is funded by the Bill & Melinda Gates Foundation (OPP1021542 and OPP113707); UK Department for International Development; Wellcome Trust, UK (093768/Z/10/Z, 108065/Z/15/Z and 203905/Z/16/Z); Swiss Agency for Development and Cooperation; US National Institutes of Health (2R01HD060338-06); and UNICEF (PCA-2017-0002)

Formalising the informal businesses in the Midlands Province of Zimbabwe: opportunities and challenges

This paper sought to investigate the challenges faced by businesses found in the informal sector in their bid to formalize their operations. Through the use of purposive sampling data was collected from informal businesses in Gweru, Zimbabwe and analysed through content analysis. The findings from the research indicate that those in the informal sector face a variety of challenges in their quest to formalize their operations. The challenges include the complexity and cost of the registration procedures, the punitive tax rates which are similar for both established businesses and small business start ups. Recommendations were made for policy makers to curb these challenges so that businesses are formalized

Formalising the informal businesses in the Midlands Province of Zimbabwe: opportunities and challenges

This paper sought to investigate the challenges faced by businesses found in the informal sector in their bid to formalize their operations. Through the use of purposive sampling data was collected from informal businesses in Gweru, Zimbabwe and analysed through content analysis. The findings from the research indicate that those in the informal sector face a variety of challenges in their quest to formalize their operations. The challenges include the complexity and cost of the registration procedures, the punitive tax rates which are similar for both established businesses and small business start ups. Recommendations were made for policy makers to curb these challenges so that businesses are formalized

Entrepreneurship education at the Midlands State University in the Midlands Province of Zimbabwe

This paper sought to explore the teaching of entrepreneurship at the Midlands State University. Through the use of convenience sampling data was collected from lecturers and students in the Midlands State University, Zimbabwe and analysed through content analysis. The findings from the research indicate that there is no alignment of the objectives with the audience, course content and the teaching methods. Recommendations were made for institution to use more of the non traditional methods of teaching which are more appropriate for educating for entrepreneurship

Entrepreneurship education at the Midlands State University in the Midlands Province of Zimbabwe

This paper sought to explore the teaching of entrepreneurship at the Midlands State University. Through the use of convenience sampling data was collected from lecturers and students in the Midlands State University, Zimbabwe and analysed through content analysis. The findings from the research indicate that there is no alignment of the objectives with the audience, course content and the teaching methods. Recommendations were made for institution to use more of the non traditional methods of teaching which are more appropriate for educating for entrepreneurship

Formalising the informal businesses in the Midlands Province of Zimbabwe: opportunities and challenges

This paper sought to investigate the challenges faced by businesses found in the informal sector in their bid to formalize their operations. Through the use of purposive sampling data was collected from informal businesses in Gweru, Zimbabwe and analysed through content analysis. The findings from the research indicate that those in the informal sector face a variety of challenges in their quest to formalize their operations. The challenges include the complexity and cost of the registration procedures, the punitive tax rates which are similar for both established businesses and small business start ups. Recommendations were made for policy makers to curb these challenges so that businesses are formalized