The fragrant floral oils of Tovomita species

The filaments of the stamens of flowers of the dioecious genus Tovomita produce droplets of fragrant oils. In T. macrophylla it was observed that the oil is collected by male euglossine bees acting as pollinators. The bees settle down on the anthers of the male flowers and the stigmas of the female flowers respectively to collect the oil with their forebarsitarsi. The oil analyses of four species from the Reserva Ducke (Manaus, Central Amazonia) were investigated revealing that the composition is different for all four species, possibly to attract selectively different euglossine species and avoid interspecific cross-pollination. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.4941009101

Microsomal metabolism of quinifuryl - a nitrofuryl-ethenyl-quinolone antiseptic possessing antitumor activity in vitro

Quinifuryl, 2-(5'-nitro-2'-furanyl)ethenyl-4-{N-[4'-(N,N-dimethylamino)-1'-methylbutyl] carbamoyl} quinoline, is a representative of a family of nitrofuran-ethenyl-quinoline antibiotics synthesized in the USSR by Dr N.M. Sukhova. The drug has been shown to be an effective cytostatic and radiosensitizer towards cancer cells in culture. While rapid metabolic consumption of these drugs by liver tissue has been shown, none of the drug metabolites have been isolated and characterized. Here, we present the results of experiments focusing on the isolation and characterization of quinifuryl metabolites. A pyridine derivative was the sole product detected and characterized by GC-MS analysis. An alteration of quinifuryl metabolism by peroxynitrite formed during the metabolism of the drug was assumed to be responsible for an unexpectedly high drug decomposition.241152

Volatile compounds of the leaves, flowers and fruits of Kielmeyera rugosa Choisy (Clusiaceae)

The essential oils from leaves, flowers, and fruits of Kielmeyera rugosa (family Clusiaceae) growing in Sergipe, north-eastern Brazil, were obtained by hydrodistillation using a Clevenger-type apparatus and analysed by GC-MS. Thirty-six components were identified in the oil from fruits, which was dominated by sesquiterpene hydrocarbons. The nine major components identified (representing 76-77% of the oil) were delta-valerolactone (1-9%), alpha-cubebene (3-4%), alpha-copaene (10-11%), beta-caryophyllene (11-16%), alpha-humulene (3-5%), alpha-selinene (4-5%), (EE)-alpha-farnesene (2-9%), delta-cadinene (23-32%) and 1-epi-cubenol (1-4%). In the leaf oil, 41 compounds were identified, with sesquiterpene hydrocarbons predominating. The 10 major constituents identified (representing 65-71% of the oil) were (Z)-3-hexen-1-ol (3%), alpha-cubebene (11-13%), alpha-copaene (11%), beta-cubebene (5-9%), beta-caryophyllene (9-13%), germacrene D (2-4%), cis-beta-guaiene (3%), alpha-selinene (6%), delta-cadinene (7-10%) and 1-epi-cubenol (3-4%). Of the 25 compounds found in the K. rugosa, flower oil, the three main components identified (representing 92.7% of the oil) were the benzenoid compounds, benzyl alcohol (18.6%), 2-phenylethanol (58.2%) and eugenol (15.9%). Copyright (c) 2006 John Wiley & Sons, Ltd.221495

Chemical constituents from Kielmeyera rugosa Choisy (Clusiaceae)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)3612921924Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)FINEPCOPES/UFSConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP

Cisto de colédoco: experiência de cinco anos com o tratamento cirúrgico no hospital municipal JESUS-RJ

OBJETIVO: Relatar a experiência no diagnóstico e tratamento do cisto de colédoco no Hospital Municipal Jesus em cinco anos (1996-2001) e a experiência brasileira publicada para o tratamento do cisto de colédoco em crianças. MÉTODO: Avaliação prospectiva dos pacientes operados com o diagnóstico de cisto de colédoco em cinco anos no Hospital Municipal Jesus. RESULTADOS: Houve predomínio de casos diagnosticados pela presença de dor abdominal recorrente, icterícia e/ou massa abdominal palpável. Apenas dois pacientes apresentavam a tríade completa. Todos os pacientes foram submetidos à ultra-sonografia e houve dúvida no diagnóstico ultra-sonográfico em apenas dois. Todos eram cistos do tipo 1 de Todani tratados através de ressecção completa e anastomose biliodigestiva em Y Roux. Houve complicações pós-operatórias imediatas em três pacientes: um caso de hemorragia digestiva alta e dois casos de fístula biliar, um deles relacionado a problemas técnicos na anastomose que necessitou de reoperação. O seguimento variou de quatro meses a cinco anos, sem detecção de complicação tardia em nenhum caso. CONCLUSÕES: O tratamento do cisto de colédoco através da ressecção completa na criança é seguro, relacionado a poucas complicações e capaz de resolver por completo a sintomatologia pré-operatória dos pacientes

Influence of different light-curing units on the surface roughness of restorative materials: in situ study

The aim of this study was to evaluate the influence of different light sources (LED and Halogen lamp) on the roughness (superficial) of composite resin (Filtek Z250, Filtek P60, Charisma and Durafill) varying post-irradiation times, in an in situ experiment. For this purpose, 80 specimens were made in polyurethane moulds. Ten volunteers without medicament use and good oral condition were selected and from them study moulds were obtained. A palatal intra-oral acrylic resin appliance was made for each of the subjects of the experiment. In each appliance, two specimens of each material were fixed (LED/Halogen lamp - control group). Roughness tests were performed immediately and 30 days after initial light-curing. Statistical analysis was performed using ANOVA. Statistically significant difference was observed only between post-irradiation times, where the 30th day showed the highest roughness values. It be concluded that roughness was influenced only by post-irradiation times, presenting the 30- days period inferior behavior