Oxalate Crystallization in the Kidney in the Presence of Hyperuricemia

It has been a long time since uric acid was suggested to be a promoting factor in calcium oxalate stones, and a number of in vitro studies have been carried out on the relationship between uric acid or urate and calcium oxalate. Concerning in vivo studies, urate or calcium oxalate stone-forming diets were given alone in most cases, and diets that induce formation of stones with different composition have not been given in combinations. We administered a low-concentration oxalemic diet, and a mixed diet containing oxalic acid and uric acid, and biochemically and histologically studied the effects of oxalate and uric acid on kidney stone formation. In the kidney of the animals given the mixed diet, formation of crystalloids of uric acid or urate was evident when no crystallization was noted in the kidney of those given the low concentration oxalemic diet alone. The morphological differences in the uric acid and urate crystalloids in the kidney and the process leading to crystallization of calcium oxalate were examined under transmission and scanning electron microscopy. Histological examination indicated that these uric acid crystals and urate crystals serve as seeds and induce formation and epitaxial growth of calcium oxalate crystals. Our in vivo study provides additional evidence that uric acid is a promoting factor in calcium oxalate stone formation

前立腺癌における血清γ-セミノプロティンの測定

前立腺癌の新しいマーカーとして, γ-セミノプロテイン(γ-Sm)と前立腺性酸性ホスファターゼ(PAP)とを比較評価した.未治療前立腺癌におけるγ-SMおよびPAPのsensitivityは, それぞれ81%, 67%であった.γ-Smはすべての病期で前立腺肥大症と比較して陽性率が高かった.前立腺癌ではγ-SmとPAPは相関を示さなかった.γ-SmとPAPを同時に測定することにより, 感度が上昇した.γ-SmおよびPAPのspecificityはそれぞれ87%と90%であった.内分泌療法を施行した病期D2において, γ-SmはPAPよりもより多く正常化した.以上より, γ-Smは前立腺癌のもう1つの有用なマーカーであるといえるSerum gamma-seminoprotein (gamma-Sm) was evaluated as a new marker for prostatic cancer in comparison with prostatic acid phosphatase (PAP). The sensitivity of gamma-Sm and PAP for untreated prostatic cancer was 81% and 67%, respectively. gamma-Sm showed a higher positive rate over all stages than in benign prostatic hypertrophy (BPH). There was no correlation between gamma-Sm and PAP in prostatic cancer. Improved sensitivity was obtained by simultaneous measurement of gamma-Sm and PAP. Specificity of gamma-Sm and PAP for BPH was 87% and 90%, respectively. gamma-Sm normalized after endocrine therapy for stage D2 more often than did PAP. These results indicate that gamma-Sm is another useful marker to evaluate prostatic cancer

興味ある尿管像を示した上部尿路結核

Urinary tuberculosis is one of the diseases continuously decreasing in number with the progress of chemotherapy and improvement in the living environment. In recent years the proportion of patients with this disease has been less than 0.5 percent of the out-patients. We encountered ureteral tuberculosis showing a pattern of diverticulum-like cystic extension arising from tuberculous ulcer, which is very interesting from a roentgenologic viewpoint. In this paper we studied on specially the mode of development of ureteral tuberculosis and its characteristic roentgenograms