Management of compressed gas cylinders in university laboratories

大学の安全管理上ならびに教職員・学生の健康障害防止上の観点からも，大学内の高圧ガスボンベの使用実態と作業環境を適切に把握し，管理することは重要な問題である。本研究では，大学における高圧ガスボンベの管理システムに関する課題とあり方について考察することを目的としている。高圧ガスボンベ管理の課題として，長期滞留ボンベの解決がある。課題解決の推進のために，新しい仕組みを導入し，管理方法を改善する取り組みを行った。新しい仕組みの導入に合わせて，共通仕様のタグの取り付けを検討した。共通仕様のタグの取り付けにより，効率良く学内の高圧ガスボンベ管理を行うことができると考えている。また，高圧ガスの取り扱いに関する教育コンテンツの充実を図り，より多くの教育を実践することが必要である。The purpose of this study was to perceive and to consider the management of compressed gas cylinders (CGC) in university laboratories. We examined the present conditions of CGC on campus, and pointed out the problems which should be improved. Cylinders were found to be preserved for an extended period of time. A new system was considered to propel this problem. Standardized tags were put on the CGCs to simplify management. There is also a need to educate students and staffs with enhanced educational material about CGC handling

Profile of mood states and stress-related biochemical indices in long-term yoga practitioners

<p>Abstract</p> <p>Background</p> <p>Previous studies have shown the short-term or intermediate-term practice of yoga to be useful for ameliorating several mental disorders and psychosomatic disorders. However, little is known about the long-term influences of yoga on the mental state or stress-related biochemical indices. If yoga training has a stress-reduction effect and also improves an individual's mental states for a long time, long-term yoga practitioners may have a better mental state and lower stress-related biochemical indices in comparison to non-experienced participants. This study simultaneously examined the differences in mental states and urinary stress-related biochemical indices between long-term yoga practitioners and non-experienced participants.</p> <p>Methods</p> <p>The participants were 38 healthy females with more than 2 years of experience with yoga (long-term yoga group) and 37 age-matched healthy females who had not participated in yoga (control group). Their mental states were assessed using the Profile of Mood States (POMS) questionnaire. The level of cortisol, 8-hydroxydeoxyguanosine (8-OHdG) and biopyrrin in urine were used as stress-related biochemical indices.</p> <p>Results</p> <p>The average self-rated mental disturbance, tension-anxiety, anger-hostility, and fatigue scores of the long-term yoga group were lower than those of the control group. There was a trend toward a higher vigor score in the long-term yoga group than that in the control group. There were no significant differences in the scores for depression and confusion in the POMS between the two groups. The urine 8-OHdG concentration showed a trend toward to being lower in the long-term yoga group in comparison to the control group. There were no significant differences in the levels of urine biopyrrin or cortisol.</p> <p>Conclusions</p> <p>The present findings suggest that long-term yoga training can reduce the scores related to mental health indicators such as self-rated anxiety, anger, and fatigue.</p

Formation and Annihilation Dynamics of Benzene Cluster Cations in Neat Liquid Benzene

第13回化学反応討論会, 1997年5月28日-30日, 北陸先端大学・石川ハイテク交流センター(金沢

DOCK2 is involved in the host genetics and biology of severe COVID-19

「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target

Management of chemical information system in the university laboratories (Part2) <Original Articles>

本論の目的は,大学における化学物質管理システムのあり方について再考察することである。特に本論では,大学における化学物質管理システムの課題を整理し改善するために必要な取り組みについて指摘をおこなった。 最初に化学物質管理システムのバージョンアップに伴う検討の過程とその結果について整理し解説を行った。また,ユーザーID の管理方法の変更に伴う影響について考察を行った。検討した結果を以下に示す。 1.化学物質管理システムを効率よく運用するには,サポート体制の整備や充実が必要である。 2.共通の化学物質データベースの整備が必要である。 3.ユーザー対応の充実やユーザー間の互換性が必要である。 4.納入業者の努力に依存しない大学が独自で運用する仕組みが必要である。 5.廃液管理と連動した仕組みの構築が必要である。The purpose of this study is to reconsider the management of chemical information systems in university laboratories. In particular, we examine the present condition of a chemical information system on a university campus in Japan, and point out conditions which need to be improved. First, both the procedures for upgrading the system and the resulting conditions are explained. Then, the effects and consequences of changing the management method concerning user IDs are examined. The following conclusions can be made: 1. Substantial support is required in order to employ a chemical management system efficiently. 2. A common chemical management database is required. 3. Compatibilities between users need to be improved. 4. A structure which functions independently from the corporation which delivers the chemical substance is required. 5. A structure interlocked with waste fluid management is required

Management of compressed gas cylinder in the university laboratories <Original Articles>

The purpose of this study is to consider the management of compressed gas cylinder (CGC) in the university laboratories. We examined the present condition of CGC in campus, and pointed out the problems which should be improved. The results about this study are listed below. 1. The CGC management tool which was developed in this time was useful in university. 2. The problem is to return "long-term CGCs" which has been kept for a long period in university laboratories. 3. The subject is education about handling of CGC for students and staffs

Consideration about the cooperation between universities about safety and health : Cooperation about safety and health between the National Universities in the Chugoku-Shikoku area <Original Articles>

中国・四国地区大学等による安全衛生協議会での安全衛生に関する取り組みについて,課題を整理し,検討するとともに,将来の中国・四国地区大学間の安全衛生に関する連携の可能性について考察した。その結果,以下のことが考えられた。 1) 安全衛生協議会では,専門的なテーマの討議とともに,初任者も参加しやすい分科会などの対応が必要である。 2) 安全衛生協議会は,大学間連携の取り組みとして,各大学の安全衛生管理の状況を把握できる簡易的なデータベースを構築し,中国・四国版の安全衛生に関するガイドライン(チエックリスト)を作成しており,さらなる改善を行いたい。 3) 今後の大学間連携として,安全衛生教育用教材の共有化やスタッフ教育の合同実施などが考えられる。 4)国立大学,高専等,私学,他の団体等との情報共有をはかり,連携を密にしていく必要がある。The purpose of this study is to consider the cooperation between the universities of the Chugoku-Shikoku region in the National University Council for the safety and health. The results are listed below. 1) In the meeting of the Council not only a discussion of a technical theme, but also a seminar for first designation person should be held. 2) As an action of the cooperation between universities, we build the simple database to grasp the situation of the safety and health management of each university, and the guidelines on Chugoku- Shikoku version“ Check List" about the safety and health. 3) As future cooperation communization of the teaching materials or joint enforcement of the staff education are considered. 4) The information sharing and cooperation among national universities, technical colleges, the private schools, and other groups are necessary

Management of chemical information system in the university laboratories <Original Articles>

The purpose of this study is to consider the management of chemical information system in the university laboratories. We examined the present condition of chemical information system in campus, and pointed out the conditions to be improved. The results about this study are listed below. 1. The chemical information system at the university is operated well. 2. The problem is to decrease the system administrator's load. 3. The problem is a practicable manual making that the user understands easily.And Execution of briefi ng of system