5 research outputs found
Diagnostic utility of CD205 in breast cancer: Simultaneous detection of myoepithelial cells and dendritic cells in breast tissue by CD205
Background. CD205 can be used to detect
myoepithelial cells (MECs) and dendritic cells (DCs) in
breast tissue. However, the usefulness of CD205
immunostaining in the pathological diagnosis of breast
tumors is not fully understood. The objective of this
study was to re-evaluate CD205 co-expression with
other MEC markers, such as p63 and CD10, in
nonneoplastic and neoplastic breast tissue and to
evaluate its pathological diagnostic utility in these types
of breast cancer.
Material and methods. Nonneoplastic breast tissue
samples with a terminal duct lobular unit and duct were
obtained from fibroadenoma and mastopathy patients.
Neoplastic breast tissue samples included ductal
carcinoma in situ (DCIS) (n=43) and invasive ductal
carcinoma (IDC) (n=60), including the tubule-forming
type (n=20). These specimens were investigated by
CD205, p63, and CD10 immunostaining.
Results. In addition to p63 and CD10, CD205 was
expressed on MECs in nonneoplastic breast and DCIS
tissue samples; CD205 was simultaneously detected on
DCs that had infiltrated DCIS and IDC tumor nests.
CD205 was expressed on cancer cells themselves in only
7.3% of the breast cancer samples. The number of
intratumoral CD205 + DCs in tubular IDC was
significantly higher than that in DCIS (P<0.01