208 research outputs found
Unusual progression of herpes simplex encephalitis with basal ganglia and extensive white matter involvement
We report a 51-year old male with herpes simplex encephalitis (HSE) showing unusual
progression and magnetic resonance (MR) findings. The initial neurological manifestation of
intractable focal seizure with low-grade fever persisted for three days, and rapidly coma,
myoclonic status, and respiratory failure with high-grade fever emerged thereafter. The
polymerase chain reaction (PCR) result of cerebrospinal fluid (CSF) was positive for HSV-1 DNA.
In the early stage, MR images (MRI) were normal. On subsequent MR diffusion-weighted (DW) and
fluid-attenuated inversion recovery (FLAIR) images, high-intensity areas first appeared in the
left frontal cortex, which was purely extra-temporal involvement, and extended into the basal
ganglia, then the white matter, which are relatively spared in HSE. Antiviral therapy and
immunosuppressive therapy did not suppress the progression of HSE, and finally severe cerebral
edema developed into cerebral herniation, which required emergency decompressive craniectomy.
Histological examination of a biopsy specimen of the white matter detected perivascular
infiltration and destruction of basic structure, which confirmed non specific inflammatory
change without obvious edema or demyelination. The present case shows both MR and pathological
findings in the white matter in the acute stage of HSE
Two cases of possible neuro-Sweet disease with meningoencephalitis as the initial manifestation
We report 2 cases that were considered to be neuro-Sweet disease. They initially manifested with meningoencephalitis and no skin lesions, and rapidly improved with corticosteroid therapy. In both cases, patients complained of meningitic symptoms such as fever and headache, and HLA-B54 and -Cw1 turned out to be positive over the clinical course. Cerebrospinal fluid analysis showed increased levels of lymphocytes and protein. In case #1, fluid-attenuated inversion recovery (FLAIR), magnetic resonance imaging (MRI) and diffusion-weighted images (DWI) showed high-intensity signals in the right dorsal medulla oblongata, bilateral dorsal midbrain, and left thalamus. In case #2, FLAIR and DWI showed high-intensity signals in the bilateral cerebellar cortex and left caudate nucleus. Symptoms and MRI images were markedly improved in both cases after corticosteroid pulse therapy. According to published diagnostic criteria, these 2 cases were considered possible neuro-Sweet disease. These cases suggest that the combination of meningoencephalitis and HLA specificity is important to consider the possibility of neuro-Sweet disease, even without skin lesions
Flavones Prevent LPS-Induced Muscle Atrophy
Muscle atrophy is a complex process that occurs as a consequence of various stress events. Muscle atrophy-associated genes (atrogenes) such as atrogin-1/MAFbx and MuRF-1 are induced early in the atrophy process, and the increase in their expression precedes the loss of muscle weight. Although antioxidative nutrients suppress atrogene expression in skeletal muscle cells, the inhibitory effects of flavonoids on inflammation-induced atrogin-1/MAFbx expression have not been clarified. Here, we investigated the inhibitory effects of flavonoids on lipopolysaccharide (LPS)-induced atrogin-1/MAFbx expression. We examined whether nine flavonoids belonging to six flavonoid categories inhibited atrogin-1/MAFbx expression in mouse C2C12 myotubes. Two major flavones, apigenin and luteolin, displayed potent inhibitory effects on atrogin-1/MAFbx expression. The pretreatment with apigenin and luteolin significantly prevented the decrease in C2C12 myotube diameter caused by LPS stimulation. Importantly, the pretreatment of LPS-stimulated myoblasts with these flavones significantly inhibited LPS-induced JNK phosphorylation in C2C12 myotubes, resulting in the significant suppression of atrogin-1/MAFbx promoter activity. These results suggest that apigenin and luteolin, prevent LPS-mediated atrogin-1/MAFbx expression through the inhibition of the JNK signaling pathway in C2C12 myotubes. Thus, these flavones, apigenin and luteolin, may be promising agents to prevent LPS-induced muscle atrophy
Radiation resistance of praseodymium-doped aluminum lithium fluorophosphate scintillator glasses for laser fusion experiments
We report the gamma (γ)-ray radiation resistance of praseodymium (Pr3+)-doped aluminum lithium fluorophosphate scintillator glasses. For its assessment as a scintillator material for laser fusion experiments, a 20Al(PO3)3-80LiF-PrF3 (Pr3+-doped APLF) glass was irradiated with γ-rays from a cobalt-60 (60Co) source resulting in an absorbed dose of 5.2 kGy. Although γ-ray-irradiation results in increased absorption due to phosphorus-oxygen hole centers (POHCs) and PO32− electron centers (PO3 ECs), these radiation-induced defects do not modify the glass emission as both non-irradiated and γ-ray-irradiated glasses exhibit similar emission spectra and decay times under optical and X-ray excitation. The emission peaks observed also correspond to the different interconfigurational 4f5d → 4f2 and intraconfigurational 4f2 transitions of Pr3+ ions which are neither oxidized nor reduced by irradiation. Our results show that Pr3+-doped APLF glass still maintains its characteristic fast decay time and that γ-ray irradiation does not affect the glass scintillation mechanisms.Shinohara K., Empizo M.J.F., Cadatal-Raduban M., et al. Radiation resistance of praseodymium-doped aluminum lithium fluorophosphate scintillator glasses for laser fusion experiments. Japanese Journal of Applied Physics 62, 010613 (2023); https://doi.org/10.35848/1347-4065/aca0d4
Recombinant human FGF-2 for the treatment of early-stage osteonecrosis of the femoral head: TRION, a single-arm, multicenter, Phase II trial
Aim: This study aimed to evaluate the 2-year outcomes from a clinical trial of recombinant human FGF-2 (rhFGF-2) for osteonecrosis of the femoral head (ONFH). Patients & methods: Sixty-four patients with nontraumatic, precollapse and large ONFHs were percutaneously administered with 800 μg rhFGF-2 contained in gelatin hydrogel. Setting the end point of radiological collapse, we analyzed the joint preservation period of the historical control. Changes in two validated clinical scores, bone regeneration and safety were evaluated. Results: Radiological joint preservation time was significantly higher in the rhFGF-2 group than in the control group. The ONFHs tended to improve to smaller ONFHs. The postoperative clinical scores significantly improved. Thirteen serious adverse events showed recovery. Conclusion: rhFGF-2 treatment increases joint preservation time with clinical efficacy, radiological bone regeneration and safety
Search for Outer Massive Bodies around Transiting Planetary Systems: Candidates of Faint Stellar Companions around HAT-P-7
We present results of direct imaging observations for HAT-P-7 taken with the
Subaru HiCIAO and the Calar Alto AstraLux. Since the close-in transiting planet
HAT-P-7b was reported to have a highly tilted orbit, massive bodies such as
giant planets, brown dwarfs, or a binary star are expected to exist in the
outer region of this system. We show that there are indeed two candidates for
distant faint stellar companions around HAT-P-7. We discuss possible roles
played by such companions on the orbital evolution of HAT-P-7b. We conclude
that as there is a third body in the system as reported by Winn et al. (2009,
ApJL, 763, L99), the Kozai migration is less likely while planet-planet
scattering is possible.Comment: 8 pages, 3 figures, 2 tables, PASJ in pres
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