6 research outputs found
Postdischarge interventions for children hospitalized with severe acute malnutrition: a systematic review and meta-analysis.
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 30/01/2021
- Field of study
BACKGROUND: Children hospitalized with severe acute malnutrition (SAM) have poor long-term outcomes following discharge, with high rates of mortality, morbidity, and impaired neurodevelopment. There is currently minimal guidance on how to support children with SAM following discharge from inpatient treatment. OBJECTIVES: This systematic review and meta-analysis aimed to examine whether postdischarge interventions can improve outcomes in children recovering from complicated SAM. METHODS: Systematic searches of 4 databases were undertaken to identify studies of interventions delivered completely or partially after hospital discharge in children aged 6-59 mo, following inpatient treatment of SAM. The main outcome of interest was mortality. Random-effects meta-analysis was undertaken where ≥2 studies were sufficiently similar in intervention and outcome. RESULTS: Ten studies fulfilled the inclusion criteria, recruiting 39-1781 participants in 7 countries between 1975 and 2015. Studies evaluated provision of zinc (2 studies), probiotics or synbiotics (2 studies), antibiotics (1 study), pancreatic enzymes (1 study), and psychosocial stimulation (4 studies). Six studies had unclear or high risk of bias in ≥2 domains. Compared with standard care, pancreatic enzyme supplementation reduced inpatient mortality (37.8% compared with 18.6%, P < 0.05). In meta-analysis there was some evidence that prebiotics or synbiotics reduced mortality (RR: 0.72; 95% CI: 0.51, 1.00; P = 0.049). Psychosocial stimulation reduced mortality in meta-analysis of the 2 trials reporting deaths (RR: 0.36; 95% CI: 0.15, 0.87), and improved neurodevelopmental scores in ≥1 domain in all studies. There was no evidence that zinc reduced mortality in the single study reporting deaths. Antibiotics reduced infectious morbidity but did not reduce mortality. CONCLUSIONS: Several biological and psychosocial interventions show promise in improving outcomes in children following hospitalization for SAM and require further exploration in larger randomized mortality trials. This study was registered with PROSPERO as CRD42018111342 (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=111342)
STUDY DF MICRDBIAL ECDLDGY DF THAI WOMEN WITH DERMATOPHYTOSIS
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Consideration and influence of climate change in environmental assessment: an analysis of British Columbia’s liquid natural gas sector
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Fitness and academic performance in adolescents. The mediating role of leptin: DADOS study
- Author
- AF Hayes
- C Currie
- CCA Santana
- CH Hillman
- D Jiménez-Pavón
- D Martinez-Gomez
- David Jiménez-Pavón
- Diego Moliner-Urdiales
- DL Adkins
- DN Ardoy
- EA Haapala
- EE Noble
- FB Ortega
- FJ Fonseca Del Pozo
- H Münzberg
- H Olmedillas
- I Esteban-Cornejo
- I Fernández
- J-P Tsai
- JE Donnelly
- Jesús Gustavo Ponce-González
- JJ Smith
- JM Tanner
- JR Ruiz
- L Chaddock
- LB Raine
- LB Sardinha
- LJ Griffiths
- M Onis de
- MA Dominguez Sanchez
- Maria Reyes Beltran-Valls
- Mireia Adelantado-Renau
- MR Beltran-Valls
- N Armstrong
- N Uysal
- OM Farr
- P Correa-Burrows
- PA Hosick
- PR Olivares
- SM Buck
- T Gunnarsdottir
- T Koester-Weber
- TJ Cole
- Óscar Chiva-Bartoll
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The rs4774 CIITA missense variant is associated with risk of systemic lupus erythematosus
- Author
- A Muhlethaler-Mottet
- A Woolfe
- B A Goldstein
- C Tian
- CCA Spencer
- CH Chang
- D Falush
- DP McGovern
- E Sanchez
- G Hom
- GM Clarke
- H Okamoto
- International_HapMap_Consortium.
- J A Kelly
- J A Lane
- J A Noble
- J B Harley
- J Yang
- J Yang
- JB Harley
- JC Barrett
- JW Han
- K B Beckman
- K L Moser
- L A Criswell
- L F Barcellos
- LF Barcellos
- M F Seldin
- M Swanberg
- MVP Linga-Reddy
- P G Bronson
- P M Gaffney
- P P Ramsay
- PC Dubois
- PC Ng
- PG Bronson
- PG Bronson
- PG Bronson
- PI de Bakker
- Q Yang
- R Kosoy
- R Lawrence
- RR Graham
- S Purcell
- ST Sherry
- SV Kozyrev
- T W Behrens
- TW Kim
- V Gateva
- V Steimle
- W Yang
- Wellcome Trust Case Control Consortium
- Z Zhang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
A second update on mapping the human genetic architecture of COVID-19
- Author
- Abd Elghafar MS
- Abdel-Aziz M
- Abdelrazik M
- Abdullah MS
- Abe R
- Abe S
- Abel L
- Abel L
- Abernathy C
- Abraham R
- Abraheem A
- Abu Alragheb BO
- Abulail JA
- Acklery A
- Acosta-Herrera M
- Adachi T
- Adachi Y
- Adam R
- Adams C
- Adams K
- Adams N
- Adanini O
- Afifi N
- Afilalo J
- Afilalo M
- Afolabi D
- Afrasiabi Z
- Afset JE
- Agasou A
- Aghemo A
- Agravante K
- Agrawal A
- Agrawal S
- Aguado JM
- Aguilar C
- Aguilar SEV
- Aguilar-Salinas CA
- Aguilera-Albesa S
- Agüero D
- Ahmad HF
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- Ahmed A
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- Ahram M
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- Ain Q
- Aitkin E
- Akeroyd L
- Akhtar MN
- Akinkugbe O
- Al-Ani A
- Al-Ja’afreh MM
- Al-Kadash A
- Al-Kasasbeh MM
- Al-Moasseb H
- Al-Muftah W
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- Alamer LM
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- Wood T
- Woodford C
- Woodruff M
- Woods L
- Woodward E
- Woodward J
- Woolcock M
- Woolley AE
- Worner R
- Worsley L
- Wray G
- Wren L
- Wreybrown C
- Wright C
- Wright DJ
- Wright J
- Wright M
- Wright S
- Wrobel N
- Wu Y
- Wulandari R
- Wylie K
- Wyllie DH
- Wynter I
- Xavier K
- Xue X
- Yagi K
- Yamada M
- Yamada Y
- Yamagata K
- Yamasaki M
- Yang J
- Yaspan B
- Yassen AM
- Yasui Y
- Yates B
- Yatomi M
- Ye C
- Yermakovich D
- Yeung RSM
- Yi X
- Yonekawa A
- Yoo S
- Yoon K
- Yoshida K
- Yoshida S
- Yoshida S
- Yoshida T
- Yoshihara T
- Yoshiya K
- Yoshiyama T
- Young M
- Yue F
- Yun N
- Yáñez CE
- Yáñez Z
- Zainulabid UA
- Zainy T
- Zak A
- Zaki A
- Zamikula J
- Zamudio IPM
- Zanella A
- Zapata-Contreras D
- Zapatamartinez M
- Zarate R
- Zarei N
- Zavaleta DAF
- Zawadzki P
- Zawati MH
- Zborowski AC
- Zeberg H
- Zechner M
- Zhang Q
- Zhao X
- Zheng C
- Zheng T
- Zhlawi HJ
- Zhlawi MWJ
- Zholdybayeva E
- Zhou W
- Zhu W
- Zitter L
- Zoller H
- Zongo O
- Zorloni C
- Zuñiga-Pacheco P
- Zárate RN
- Zúñiga-Ramos J
- Álvarez BG
- Ávila-Arcos MA
- Ávila-Arcos MC
- Özer O
- Überla K
- Þorsteinsdóttir U
- Publication venue
- Nature Research
- Publication date
- 21/06/2023
- Field of study