Effects of Englerina drummondii Balle ex Polhill and Wiens leaves extract on selected female rat organs’ weights

Background: Herbal medicine are patronized by several people across the globe This herbal medicine is routinely use and are more accessible and available. This study aimed to investigate the effects of Englerina drummondii Balle ex Polhill and Wiens leaves on rat organs (thyroid gland, kidneys, ovary and fallopian tubes) weights in female rats. Methods: 20 female rats were selected randomly into 4 groups with 5 rats per group. Group 1 received 5 ml/kg of water, group 2 received extract 100 mg/kg, group 3 received extract 200 mg/kg, and group 4 received extract 400 mg/kg. Administration of extract was done for 28 days. Results: The study revealed significance decreased in the weight of the left ovary organ when extract of medium dose (200 mg/kg) and high dose (400 mg/kg) was administered, as compared to control. The result also shows decrease in the organs weight of the thyroid gland, left kidney, right and left fallopian tubes extract of low, medium and high dose were administered. The right kidney shows increase when low dose extract was given but decrease when both low and medium dose of extract was given. However, this decrease is not significance and could be due to dose or time dependent. Statistical analysis was done using statistical package for the social sciences (SPSS) version 23 and p<0.05 was significant. Conclusions: There was significance decreased in the weight of the left ovary organ when extract of medium dose (200 mg/kg) and high dose (400 mg/kg) was administered. Also, there is decrease in other organs weight when low, medium and high dose was given but not significance

Effects of hydro-alcohol extract of mistletoe leaves on changes in body-weight, uterus-weight, right ovary and liver in female rats

 Background: Most people across rural areas in Africa depends of phytomedicine for the treatment of various diseases. This study aims to evaluate the impact of hydro-alcohol extract of mistletoe leaves on changes in body-weight, uterus-weight, ovary and liver of female Wistar rats.Methods: Forty-nine female rats were randomly selected into nine groups with five rats per group. Group 1 received 5 ml/kg of water, group 2 received mono sodium glutamate (MSG) 800 mg/kg, group 3 received extract 100 mg/kg, group 4 received extract 200 mg/kg, group 5 received extract 400 mg/kg, group 6 received extract 100 mg/kgand MSG 800 mg/kg, group 7 received extract 200 mg/kgand MSG 800vmg/kg, group 8 received extract 400 mg/kg and MSG 800 mg/kg and group 9 received letrozole 0.6 mg/kg and MSG 800 mg/kg. Administration of extract was done for 28 days.Results: Findings from the study revealed significance decreased in the final weight of the animals. When treated groups received extract “100 mg/kg, extract 200 mg/kg, extract 400 mg/kg, and extract 200 mg/kg and MSG 800 mg/kg”, it shows significance decreased in body weight difference. The results also show significance increased in the weight of the right ovary in the treated groups extract 100 mg/kg, extract 100 mg/kg and MSG 800 mg/kg. Extract 100 mg/kg, extract 400 mg/kg and MSG 800 mg/kg and letrozole 0.6 mg/kg and MSG 800 mg/kg, shows significance decreased in the weight of the uterus. MSG 800 mg/kg, “extract 100 mg/kg, extract 200 mg/kg, and extract 400 mg/kg”, it shows significance decreased in the weight of the liver. Statistical analysis was done using statistical package for the social sciences (SPSS) version 23 and p<0.05 was significant.Conclusions: There was significance decreased in rat’s body weight and significant increase in the right ovary when a lower dose of the extract was given and this increase could be due to MSG. The uterus significantly decreases when low dose of the extract was administered and the liver organ also has significant decreased in all the groups treated with extract alone