INFLUENCE OF CANCER SEVERITY AND FUNCTIONAL STATUS OF CANCER ON CARDIAC PARASYMPATHETIC INDICATORS

 Objective: To investigate the influence of cancer severity and functional status of cancer patients on cardiac parasympathetic indicators. Methods: A total of 267 patients with a fresh clinical diagnosis of solid malignant tumor not yet put on cancer therapy and 250 controls matched for age, sex of study subjects were included. Severity of cancer was defined based on the American Joint Committee on Cancer staging. Accordingly, study subjects were subdivided into early stage (Stage I and II combined) and advanced stage (Stage III and IV combined). In cancer patients, the Eastern Cooperative Oncology Group (ECOG) performance score and the Faces Pain Scale score (FPS) was noted. Two indicators of vagal function, expiratory:inspiratory ratio (E:I ratio) and root mean square of successive N-N interval difference (r-MSSD) were included. E:I ratio during deep breathing at six respiratory cycles/minute and r-MSSD at rest was obtained from 1 minute lead II electrocardiogram. Data were analyzed by applying suitable statistical tests. p≤0.05 was considered significant. Results: R-MSSD and E:I ratio was significantly reduced in the early and advanced stage of cancer compared to controls (p≤0.0001). r-MSSD and E:I ratio was significantly reduced in advanced stage compared to the early stage of cancer (p≤0.0001). r-MSSD and E:I ratio was significantly different in subgroups of stages of cancer and controls (p≤0.0001). In cancer patients, r-MSSD was negatively correlated with ECOG and FPS score (p≤0.0278, p≤0.0100). Conclusion: Severity of cancer affects vagal function. However, r-MSSD alone was associated with functional status (ECOG, FPS) of cancer patients

A COMPARATIVE STUDY ON CARDIOVASCULAR PARAMETERS AND LIPIDS IN METABOLIC SYNDROME WITH AND WITHOUT DIABETES MELLITUS

Abstract:Metabolic syndrome (MS) and diabetes mellitus (DM) are risk factors for cardiovascular disease. But influence of MS in presence of DM on cardiovascular risk factors is less described. This study evaluated the combined effect of MS and DM on blood pressure (BP) heart rate (HR) and lipids. In 39 subjects with MS alone (group A) and 38 subjects with MS and DM (group B), plasma total cholesterol, triglycerides, low density and high density lipoprotein -cholesterol , fasting blood sugar, BP and HR were noted . The mean HR, diastolic blood pressure (DBP) of group B was higher compared to group A (p = 0.0345; 0.027 respectively). Mean total cholesterol, triglycerides and low density lipoproteins of group B was higher compared to group A (p = 0.0155, 0.033, 0.0055 respectively) In conclusion, MS in presence of DM causes raise in DBP, low-density lipoprotein and triglyceride