Study on Soil-Water Characteristics of Expansive Soil under the Dry-Wet Cycle and Freeze-Thaw Cycle considering Volumetric Strain

This paper targets the expansive soils in Heilongjiang and Ankang to explore the influence of initial dry density, dry-wet cycle, and freeze-thaw cycle on the soil-water characteristics. The centrifuge method was used to obtain the soil-water characteristic curves (SWCCs) with different conditions. The volumetric strain of SWCC was modified based on the shrinkage test, and the corresponding fitting equations considering different factors were established. The results show that the volumetric water content is modified to consider the volume shrinkage effect of expansive soil, and the modification is more obvious in the high matric suction range. The smaller the initial dry density is, the worse the water-holding capacity of the sample is, and the smaller the air intake value is. The greater the time of the dry-wet cycle is, the greater the saturated volumetric water content of the sample is, and the corresponding water-holding capacity is significantly reduced. When the dry-wet cycle increases to a certain extent, the structure becomes stable. With the increase of the freeze-thaw cycle, the saturated volumetric water content first decreases and then increases. Similarly, after several times of the freeze-thaw cycle, the structure is basically stable. The fitted Gardner model equations under different conditions were proved to be able to describe the SWCCs of the two targeted expansive soils

Three-dimensional architectures for highly stable pure blue emission

Four three-dimensionally architectured molecules 1a-d with spiro-annulated structural features were facilely developed. 1a and 1b form uniform and amorphous films via spin-coating due to their rigid three-dimensional architecture. The PL spectra of 1a-d exhibit 0 excellent thermal stability upon air annealing. Their blue color integrity remained after continuous annealing for 12 h at 200 C in the air. OLED fabrication reveals that all 1a-d exhibit pure blue EL performance and good color integrity at different operating voltages

Correction: Ping Meng, et al. Involvement of the Interleukin-23/Interleukin-17 Axis in Chronic Hepatitis C Virus Infection and Its Treatment Responses. Int. J. Mol. Sci. 2016, 17, 1070

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Involvement of the Interleukin-23/Interleukin-17 Axis in Chronic Hepatitis C Virus Infection and Its Treatment Responses

Interleukin-23 (IL-23) and its downstream factor IL-17 are the key cytokines involved in immune and inflammatory response in chronic liver diseases. This study aimed to investigate the role and molecular mechanisms of the IL-23/Th17 axis in chronic hepatitis C virus (HCV) infection, and the efficacy of IL-23/Th17 modulation in response to anti-HCV therapy. Sixty-six HCV-infected patients and 20 healthy controls were enrolled. The patients received PegIFNa-2a and ribavirin therapy for at least 48 weeks. The plasma level of IL-23 and the number of IL-17A-, IFN-γ-, and IL-21-producing peripheral blood mononuclear cells (PBMCs) at baseline and 12, 24, and 48 weeks following treatment were determined. The mRNA level of Th17 immune-associated molecules in PBMCs was evaluated by real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) following treatment with IL-23 agonist or antagonist. Our data showed that, compared to healthy controls, HCV-infected patients had an increased plasma level of IL-23 and increased frequencies of IL-17A- and IFN-γ-producing PBMCs, whereas the HCV patients exhibited a reduced number of IL-21-producing PBMCs. However, the baseline frequencies of IL-21-producing PBMCs were markedly higher in HCV patients who achieved rapid virological response (RVR) than those without RVR. Additionally, the mRNA expressions of IL-21, IFN-γ, myxovirus resistance protein A (MxA), and suppressor of cytokine signaling 3 (SOCS3) were significantly upregulated in PBMCs, while FoxP3 expression was suppressed by IL-23 agonist. Thus, the IL-23/Th17 axis plays an important role in development of chronic HCV infection and antiviral response. IL-23 may enhance the antiviral activity of interferon-based therapy by modulating the expression of Th17 cells-associated molecules in HCV-infected patients

Reduced hepatic bradykinin degradation accounts for cold-induced BAT thermogenesis and WAT browning in male mice

Abstract An important role for liver in the regulation of adipose tissue thermogenesis upon cold exposure has been suggested; however, the underlying mechanisms remain incompletely defined. Here, we identify elevated serum bradykinin levels in response to acute cold exposure in male mice. A bolus of anti-bradykinin antibodies reduces body temperature during acute cold exposure, whereas bradykinin has the opposite effect. We demonstrate that bradykinin induces brown adipose tissue thermogenesis and white adipose tissue browning, and bradykinin increases uncoupling protein 1 (UCP1) expression in adipose tissue. The bradykinin B2 receptor (B2R), adrenergic signaling and nitric oxide signaling are involved in regulating bradykinin-increased UCP1 expression. Moreover, acute cold exposure inhibits hepatic prolyl endopeptidase (PREP) activity, causing reduced liver bradykinin degradation and increased serum bradykinin levels. Finally, by blocking the breakdown of bradykinin, angiotensin-converting enzyme inhibitors (ACEIs) increase serum bradykinin levels and induce brown adipose tissue thermogenesis and white adipose tissue browning via B2R. Collectively, our data provide new insights into the mechanisms underlying organ crosstalk in whole-body physiology control during cold exposure and also suggest bradykinin as a possible anti-obesity target