7-Methoxy-2-phenylchroman-4-one

In the title compound, C 16 H 14 O 3 , the ring O atom and the two adjacent non-fused C atoms, as well as the attached phenyl ring, exhibit static disorder [occupancy ratio 0.559 (12): 0.441 (12)]. The crystal packing features – [centroid– centroid distance = 3.912 (1) A ̊ ] and C—H interactions.In the title compound, C16H14O3, the ring O atom and the two adjacent non-fused C atoms, as well as the attached phenyl ring, exhibit static disorder [occupancy ratio 0.559 (12):0.441 (12)]. The crystal packing features [pi]-[pi] [centroid-centroid distance = 3.912 (1) Å] and C-H...[pi] inter­actions

Preparation, structural characterization, and decomposition studies of two new γ-octamolybdates of 4-methylpyridine

We synthesized two new c -octamolybdates, and determined their crystal structures from single-crystal X-ray diffraction data. Orange-yellow tetrakis(4-meth- ylpyridinium) bis(4-methylpyridine)- c -octamolybdate 1 crystallizes in space group P2 1 /c with a = 11.586(2) A ̊ , b = 15.526(2) A ̊ , c = 16.247(2) A ̊ , b = 118.753(1) 8 , Z = 2. White tetrakis(4-methylpyridinium) bis(4-methyl- pyridine)- c -octamolybdate hydrate 2 crystallizes in space group C2/c with a = 27.086(4) A ̊ , b = 11.917(2) A ̊ , c = 19.332(2) A ̊ , b = 124.427(1) 8 , Z = 4. Results of crystal structure determinations are presented and dis- cussed in this paper. Thermal stability and decomposition studies of the obtained two new c -octamolybdates were performed using TG/DSC and XRPD methods. Both compounds decomposed with the formation of 4-meth- ylpyridinium b -octamolybdate. The two compounds are pseudo-polymorphs, exhibiting both striking similarities as well as significant differences in their structures and properties

5-Arylidenerhodanines as P-gp modulators : an interesting effect of the carboxyl group on ABCB1 function in multidrug-resistant cancer cells

Multidrug resistance (MDR) is considered one of the major mechanisms responsible for the failure of numerous anticancer and antiviral chemotherapies. Various strategies to overcome the MDR phenomenon have been developed, and one of the most attractive research directions is focused on the inhibition of MDR transporters, membrane proteins that extrude cytotoxic drugs from living cells. Here, we report the results of our studies on a series newly synthesized of 5-arylidenerhodanines and their ability to inhibit the ABCB1 efflux pump in mouse T-lymphoma cancer cells. In the series, compounds possessing a triphenylamine moiety and the carboxyl group in their structure were of particular interest. These amphiphilic compounds showed over 17-fold stronger efflux pump inhibitory effects than verapamil. The cytotoxic and antiproliferative effects of target rhodanines on T-lymphoma cells were also investigated. A putative binding mode for 11, one of the most potent P-gp inhibitors tested here, was predicted by molecular docking studies and discussed with regard to the binding mode of verapamil

5-Arylidenerhodanines as P-gp Modulators: An Interesting Effect of the Carboxyl Group on ABCB1 Function in Multidrug-Resistant Cancer Cells

Multidrug resistance (MDR) is considered one of the major mechanisms responsible for the failure of numerous anticancer and antiviral chemotherapies. Various strategies to overcome the MDR phenomenon have been developed, and one of the most attractive research directions is focused on the inhibition of MDR transporters, membrane proteins that extrude cytotoxic drugs from living cells. Here, we report the results of our studies on a series newly synthesized of 5-arylidenerhodanines and their ability to inhibit the ABCB1 efflux pump in mouse T-lymphoma cancer cells. In the series, compounds possessing a triphenylamine moiety and the carboxyl group in their structure were of particular interest. These amphiphilic compounds showed over 17-fold stronger efflux pump inhibitory effects than verapamil. The cytotoxic and antiproliferative effects of target rhodanines on T-lymphoma cells were also investigated. A putative binding mode for 11, one of the most potent P-gp inhibitors tested here, was predicted by molecular docking studies and discussed with regard to the binding mode of verapamil