505 research outputs found
Symmetric Operation of the Resonant Exchange Qubit
We operate a resonant exchange qubit in a highly symmetric triple-dot
configuration using IQ-modulated RF pulses. At the resulting three-dimensional
sweet spot the qubit splitting is an order of magnitude less sensitive to all
relevant control voltages, compared to the conventional operating point, but we
observe no significant improvement in the quality of Rabi oscillations. For
weak driving this is consistent with Overhauser field fluctuations modulating
the qubit splitting. For strong driving we infer that effective voltage noise
modulates the coupling strength between RF drive and the qubit, thereby
quickening Rabi decay. Application of CPMG dynamical decoupling sequences
consisting of up to n = 32 {\pi} pulses significantly prolongs qubit coherence,
leading to marginally longer dephasing times in the symmetric configuration.
This is consistent with dynamical decoupling from low frequency noise, but
quantitatively cannot be explained by effective gate voltage noise and
Overhauser field fluctuations alone. Our results inform recent strategies for
the utilization of partial sweet spots in the operation and long-distance
coupling of triple-dot qubits.Comment: 6 pages, 5 figure
Negative spin exchange in a multielectron quantum dot
By operating a one-electron quantum dot (fabricated between a multielectron
dot and a one-electron reference dot) as a spectroscopic probe, we study the
spin properties of a gate-controlled multielectron GaAs quantum dot at the
transition between odd and even occupation number. We observe that the
multielectron groundstate transitions from spin-1/2-like to singlet-like to
triplet-like as we increase the detuning towards the next higher charge state.
The sign reversal in the inferred exchange energy persists at zero magnetic
field, and the exchange strength is tunable by gate voltages and in-plane
magnetic fields. Complementing spin leakage spectroscopy data, the inspection
of coherent multielectron spin exchange oscillations provides further evidence
for the sign reversal and, inferentially, for the importance of non-trivial
multielectron spin exchange correlations.Comment: 8 pages, including 4 main figures and 2 supplementary figurure
Noise suppression using symmetric exchange gates in spin qubits
We demonstrate a substantial improvement in the spin-exchange gate using
symmetric control instead of conventional detuning in GaAs spin qubits, up to a
factor-of-six increase in the quality factor of the gate. For symmetric
operation, nanosecond voltage pulses are applied to the barrier that controls
the interdot potential between quantum dots, modulating the exchange
interaction while maintaining symmetry between the dots. Excellent agreement is
found with a model that separately includes electrical and nuclear noise
sources for both detuning and symmetric gating schemes. Unlike exchange control
via detuning, the decoherence of symmetric exchange rotations is dominated by
rotation-axis fluctuations due to nuclear field noise rather than direct
exchange noise.Comment: 5 pages main text (4 figures) plus 5 pages supplemental information
(3 figures
Spectrum of the Nuclear Environment for GaAs Spin Qubits
Using a singlet-triplet spin qubit as a sensitive spectrometer of the GaAs
nuclear spin bath, we demonstrate that the spectrum of Overhauser noise agrees
with a classical spin diffusion model over six orders of magnitude in
frequency, from 1 mHz to 1 kHz, is flat below 10 mHz, and falls as for
frequency Hz. Increasing the applied magnetic field from
0.1 T to 0.75 T suppresses electron-mediated spin diffusion, which decreases
spectral content in the region and lowers the saturation frequency,
each by an order of magnitude, consistent with a numerical model. Spectral
content at megahertz frequencies is accessed using dynamical decoupling, which
shows a crossover from the few-pulse regime ( -pulses),
where transverse Overhauser fluctuations dominate dephasing, to the many-pulse
regime ( -pulses), where longitudinal Overhauser
fluctuations with a spectrum dominate.Comment: 6 pages, 4 figures, 8 pages of supplementary material, 5
supplementary figure
ASAS-EULAR recommendations for the management of axial spondyloarthritis: 2022 update
Objectives: To update the Assessment of SpondyloArthritis international Society (ASAS)-EULAR recommendations for the management of axial spondyloarthritis (axSpA).
Methods: Following the EULAR Standardised Operating Procedures, two systematic literature reviews were conducted on non-pharmacological and pharmacological treatment of axSpA. In a task force meeting, the evidence was presented, discussed, and overarching principles and recommendations were updated, followed by voting.
Results: Five overarching principles and 15 recommendations with a focus on personalised medicine were agreed: eight remained unchanged from the previous recommendations; three with minor edits on nomenclature; two with relevant updates (#9, 12); two newly formulated (#10, 11). The first five recommendations focus on treatment target and monitoring, non-pharmacological management and non-steroidal anti-inflammatory drugs (NSAIDs) as first-choice pharmacological treatment. Recommendations 6-8 deal with analgesics and discourage long-term glucocorticoids and conventional synthetic disease-modifying antirheumatic drugs (DMARDs) for pure axial involvement. Recommendation 9 describes the indication of biological DMARDs (bDMARDs, that is, tumour necrosis factor inhibitors (TNFi), interleukin-17 inhibitors (IL-17i)) and targeted synthetic DMARDs (tsDMARDs, ie, Janus kinase inhibitors) for patients who have Ankylosing Spondylitis Disease Activity Score ≥2.1 and failed ≥2 NSAIDs and also have either elevated C reactive protein, MRI inflammation of sacroiliac joints or radiographic sacroiliitis. Current practice is to start a TNFi or IL-17i. Recommendation 10 addresses extramusculoskeletal manifestations with TNF monoclonal antibodies preferred for recurrent uveitis or inflammatory bowel disease, and IL-17i for significant psoriasis. Treatment failure should prompt re-evaluation of the diagnosis and consideration of the presence of comorbidities (#11). If active axSpA is confirmed, switching to another b/tsDMARD is recommended (#12). Tapering, rather than immediate discontinuation of a bDMARD, can be considered in patients in sustained remission (#13). The last recommendations (#14, 15) deal with surgery and spinal fractures.
Conclusions: The 2022 ASAS-EULAR recommendations provide up-to-date guidance on the management of patients with axSpA.
Keywords: Biological Therapy; Spondyloarthritis; Therapeutic
Fast spin exchange between two distant quantum dots
The Heisenberg exchange interaction between neighboring quantum dots allows
precise voltage control over spin dynamics, due to the ability to precisely
control the overlap of orbital wavefunctions by gate electrodes. This allows
the study of fundamental electronic phenomena and finds applications in quantum
information processing. Although spin-based quantum circuits based on
short-range exchange interactions are possible, the development of scalable,
longer-range coupling schemes constitutes a critical challenge within the
spin-qubit community. Approaches based on capacitative coupling and
cavity-mediated interactions effectively couple spin qubits to the charge
degree of freedom, making them susceptible to electrically-induced decoherence.
The alternative is to extend the range of the Heisenberg exchange interaction
by means of a quantum mediator. Here, we show that a multielectron quantum dot
with 50-100 electrons serves as an excellent mediator, preserving speed and
coherence of the resulting spin-spin coupling while providing several
functionalities that are of practical importance. These include speed (mediated
two-qubit rates up to several gigahertz), distance (of order of a micrometer),
voltage control, possibility of sweet spot operation (reducing susceptibility
to charge noise), and reversal of the interaction sign (useful for dynamical
decoupling from noise).Comment: 6 pages including 4 figures, plus 8 supplementary pages including 5
supplementary figure
Sacroiliac joint radiographic progression in axial spondyloarthritis is retarded by the therapeutic use of TNF inhibitors: 12-year data from the SCQM registry.
OBJECTIVES
To analyse the effect of tumour necrosis factor inhibitors (TNFi) on sacroiliac joint (SIJ) radiographic progression in axial spondyloarthritis (axSpA).
METHODS
Patients with axSpA in the Swiss Clinical Quality Management cohort with up to 12 years of follow-up and radiographic assessments every 2 years were included. SIJs were scored by two readers according to the modified New York criteria blinded to chronology. The relationship between TNFi use before or during a 2-year radiographic interval and SIJ progression was investigated using generalised estimating equation models with adjustment for potential confounding. Progression was defined as worsening of ≥1 grade in ≥1 SIJ and ignoring a change from 0 to 1 over 2 years, if both readers agreed. A third reading of radiographs was integrated in sensitivity analyses.
RESULTS
A total of 515 patients with axSpA contributed to data for 894 radiographic intervals (24 progression events). In patients with complete covariate data, prior use of TNFi reduced the odds of progression (OR 0.21, 95% CI 0.07 to 0.65). A comparable effect was found for use of TNFi for ≥1 year within a 2-year radiographic interval (OR 0.21, 95% CI 0.08 to 0.55). The inhibitory impact of TNFi was confirmed if progression was demonstrated in 2/3 readings: OR 0.50, 95% CI 0.28 to 0.89 and OR 0.46, 95% CI 0.27 to 0.78 for TNFi treatment before and for ≥1 year within the interval, respectively.
CONCLUSION
TNFi are associated with deceleration of SIJ radiographic progression in patients with axSpA if treatment is continued for ≥1 year
Sacroiliac joint radiographic progression in axial spondyloarthritis is retarded by the therapeutic use of TNF inhibitors: 12-year data from the SCQM registry
OBJECTIVES: To analyse the effect of tumour necrosis factor inhibitors (TNFi) on sacroiliac joint (SIJ) radiographic progression in axial spondyloarthritis (axSpA).
METHODS: Patients with axSpA in the Swiss Clinical Quality Management cohort with up to 12 years of follow-up and radiographic assessments every 2 years were included. SIJs were scored by two readers according to the modified New York criteria blinded to chronology. The relationship between TNFi use before or during a 2-year radiographic interval and SIJ progression was investigated using generalised estimating equation models with adjustment for potential confounding. Progression was defined as worsening of ≥1 grade in ≥1 SIJ and ignoring a change from 0 to 1 over 2 years, if both readers agreed. A third reading of radiographs was integrated in sensitivity analyses.
RESULTS: A total of 515 patients with axSpA contributed to data for 894 radiographic intervals (24 progression events). In patients with complete covariate data, prior use of TNFi reduced the odds of progression (OR 0.21, 95% CI 0.07 to 0.65). A comparable effect was found for use of TNFi for ≥1 year within a 2-year radiographic interval (OR 0.21, 95% CI 0.08 to 0.55). The inhibitory impact of TNFi was confirmed if progression was demonstrated in 2/3 readings: OR 0.50, 95% CI 0.28 to 0.89 and OR 0.46, 95% CI 0.27 to 0.78 for TNFi treatment before and for ≥1 year within the interval, respectively.
CONCLUSION: TNFi are associated with deceleration of SIJ radiographic progression in patients with axSpA if treatment is continued for ≥1 year
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