Various Care Option of Integrative Medicine from the Viewpoint of Patient-Oriented Medicine

Authors and colleagues have managed Shikoku Island division of Integrative Medicine Japan (IMJ) and continued various activities. There were several important conferences in 2019 concerning Integrative Medicine (IM) and Complementary and Alternative Medicine (CAM). World Federation of Chinese Medicine Societies held the 4th cancer rehabilitation seminar in Nagoya, as cooperation with IMJ in May. There was annual congress of our Shikoku division in October, with 14 various lectures such as music therapy, chiropractic, rehabilitation, Hinohara-ism and so on. Annual IMJ congress was held at Kagoshima in December with 1000 attendees and 100 presentations. The keynote speech by Dr. Noriko Yoshida was impressive for remarkable projects, such as national health project, long life & treasure child project, music exercise therapy with traditional song and dance, centenarian research project, island health thalasso-tourism, and psychotherapy. Author gave comments about mindfulness originated from Budhism, Pythagoreanism from Pythagoras and Hinohara-ism from famous Japanese physician Shigeaki Hinohara. These philosophies have common aspect of patient-oriented medicine, which are crucial element for IM and CAM

Pairing Situation of Soundscape and Flavors from Integrative Medicine (IM) Point Of View

For Integrative medicine (IM), the authors have continued to practice music therapy and manage the Integrative Medicine Japan (IMJ), Shikoku Island Division for years. This article describes the pairing situation of soundscape/hearing and flavor/smell. Several crossmodal correspondences include flavorful stimuli, sound stimuli, shapes, colors, textures, and so on. Various kinds of food include chocolate, coffee, wine, whiskey, cognac and others. The perceptual association between them is called sonic seasoning. When tasting wine with music, possible perspectives include pleasure, response, analysis and description. Basic perceptual similarities in the olfactory and auditory stimuli show high or low notes, harmonies and chords

Music and Man in Art : The Future of Media and Technology

Music can provide psychological benefit, and music therapy has been accepted for many people across the world. Iso-principle has been known as an important concept in music therapy. Art is roughly divided into two categories, which are visual arts and reproducing arts. An attempt to overlap these categories would be a method of recording and playing back music. Historically, human could come to experience polyphonic music like the instrument of Carillon, to listen to reproducing music by music score and phonograph, and to be enjoy music anytime by use of media and technology. Recent music environment includes the voice synthesis technology "VOCALOID", a video distribution site on the internet. In the future, music will make people happier if new technologies are widely recognized and personalized use is widespread

Music Has Various Aspects as Culture, Communication, Medicine and Music Therapy

In the evolution of mammals, human beings have often felt anxiety and fear, but sometimes felt safety, euphoria, love and well-being with communicative musicality and linguistic circumstance. For a baby, her mother will present proto-conversation by music and verbal communication for interactive relationship. There has been a question how music may have originated associated with some features. Several factors are involved including transmission of the culture, gathering of people, various music pattern, human vocal singing and entrainment with synchrony. Consequently, music includes its great meaningful power in the human body and soul for music therapy, leading to human happiness

Basic Function of Sensory-Motor Transformations for Music Activity Associated with Human Six Senses

In the field of Complementary and Alternative Medicine (CAM), music therapy (MT) has been known and widely accepted. Authors are registered music therapists (rMTs), and continued research for MT and piano-playing. Human has five senses including hearing, sight, smell, taste and touch. Stimuli of auditory, visual and somatosensory data assemble into post parietal region, which are transmitted to prefrontal cortex. This is called as sensory-motor transformations (SMT). Consequently, neuroimaging can demonstrate several factors for activation of various brain areas, which generate the perception of musical and emotional feeling. Further research development is expected for brain function, SMT and piano-playing

Who died as a result of the tsunami? – Risk factors of mortality among internally displaced persons in Sri Lanka: a retrospective cohort analysis

BACKGROUND: Describing adverse health effects and identifying vulnerable populations during and after a disaster are important aspects of any disaster relief operation. This study aimed to describe the mortality and related risk factors which affected the displaced population over a period of two and a half months after the 2004 Indian Ocean tsunami in an eastern coastal district of Sri Lanka. METHODS: A cross-sectional household survey was conducted in 13 evacuation camps for internally displaced persons (IDP). Information on all pre-tsunami family members was collected from householders, and all deaths which occurred during the recall period (77 to 80 days starting from the day of the tsunami) were recorded. The distribution of mortality and associated risk factors were analysed. Logistic regression modelling using the generalized estimating equations method was applied in multivariate analysis. RESULTS: Overall mortality rate out of 3,533 individuals from 859 households was 12.9% (446 deaths and 11 missing persons). The majority of the deaths occurred during and immediately after the disaster. A higher mortality was observed among females (17.5% vs. 8.2% for males, p < 0.001), children and the elderly (31.8%, 23.7% and 15.3% for children aged less than 5 years, children aged 5 to 9 years and adults over 50 years, respectively, compared with 7.4% for adults aged 20 to 29 years, p < 0.001). Other risk factors, such as being indoors at the time of the tsunami (13.8% vs. 5.9% outdoors, p < 0.001), the house destruction level (4.6%, 5.5% and 14.2% in increasing order of destruction, p < 0.001) and fishing as an occupation (15.4% vs. 11.2% for other occupations, p < 0.001) were also significantly associated with increased mortality. These correlations remained significant after adjusting for the confounding effects by multivariate analysis. CONCLUSION: A significantly high mortality was observed in women and children among the displaced population in the eastern coastal district of Sri Lanka who were examined by us. Reconstruction activities should take into consideration these changes in population structure

Nuclear structure of 30S and its implications for nucleosynthesis in classical novae

The uncertainty in the 29P(p,gamma)30S reaction rate over the temperature range of 0.1 - 1.3 GK was previously determined to span ~4 orders of magnitude due to the uncertain location of two previously unobserved 3+ and 2+ resonances in the 4.7 - 4.8 MeV excitation region in 30S. Therefore, the abundances of silicon isotopes synthesized in novae, which are relevant for the identification of presolar grains of putative nova origin, were uncertain by a factor of 3. To investigate the level structure of 30S above the proton threshold (4394.9(7) keV), a charged-particle spectroscopy and an in-beam gamma-ray spectroscopy experiments were performed. Differential cross sections of the 32S(p,t)30S reaction were measured at 34.5 MeV. Distorted wave Born approximation calculations were performed to constrain the spin-parity assignments of the observed levels. An energy level scheme was deduced from gamma-gamma coincidence measurements using the 28Si(3He,n-gamma)30S reaction. Spin-parity assignments based on measurements of gamma-ray angular distributions and gamma-gamma directional correlation from oriented nuclei were made for most of the observed levels of 30S. As a result, the resonance energies corresponding to the excited states in 4.5 MeV - 6 MeV region, including the two astrophysically important states predicted previously, are measured with significantly better precision than before. The uncertainty in the rate of the 29P(p,gamma)30S reaction is substantially reduced over the temperature range of interest. Finally, the influence of this rate on the abundance ratios of silicon isotopes synthesized in novae are obtained via 1D hydrodynamic nova simulations.Comment: 22 pages, 12 figure

Prolyl isomerase Pin1 promotes survival in EGFR-mutant lung adenocarcinoma cells with an epithelial-mesenchymal transition phenotype

EGFR mutant肺腺癌には逆説的ながらEGFRへの依存性が低い癌細胞が含まれている。本研究では，“EGFR非依存性”EGFR mutant肺腺癌には異性化酵素Pin1に強く依存するものが存在することを示した

A Host Small GTP-binding Protein ARL8 Plays Crucial Roles in Tobamovirus RNA Replication

Tomato mosaic virus (ToMV), like other eukaryotic positive-strand RNA viruses, replicates its genomic RNA in replication complexes formed on intracellular membranes. Previous studies showed that a host seven-pass transmembrane protein TOM1 is necessary for efficient ToMV multiplication. Here, we show that a small GTP-binding protein ARL8, along with TOM1, is co-purified with a FLAG epitope-tagged ToMV 180K replication protein from solubilized membranes of ToMV-infected tobacco (Nicotiana tabacum) cells. When solubilized membranes of ToMV-infected tobacco cells that expressed FLAG-tagged ARL8 were subjected to immunopurification with anti-FLAG antibody, ToMV 130K and 180K replication proteins and TOM1 were co-purified and the purified fraction showed RNA-dependent RNA polymerase activity that transcribed ToMV RNA. From uninfected cells, TOM1 co-purified with FLAG-tagged ARL8 less efficiently, suggesting that a complex containing ToMV replication proteins, TOM1, and ARL8 are formed on membranes in infected cells. In Arabidopsis thaliana, ARL8 consists of four family members. Simultaneous mutations in two specific ARL8 genes completely inhibited tobamovirus multiplication. In an in vitro ToMV RNA translation-replication system, the lack of either TOM1 or ARL8 proteins inhibited the production of replicative-form RNA, indicating that TOM1 and ARL8 are required for efficient negative-strand RNA synthesis. When ToMV 130K protein was co-expressed with TOM1 and ARL8 in yeast, RNA 5′-capping activity was detected in the membrane fraction. This activity was undetectable or very weak when the 130K protein was expressed alone or with either TOM1 or ARL8. Taken together, these results suggest that TOM1 and ARL8 are components of ToMV RNA replication complexes and play crucial roles in a process toward activation of the replication proteins' RNA synthesizing and capping functions