Effect of Thermal Processing On the Biochemical Parameters of Radish

Abstract: The effect of thermal processing on pink coloured radish were determined using antray and freeze dryer at different temperatures (60 0 C, 70 0 C and 80 0 C) and (-40 0 C, -50 0 C,-60 0 C). The ascorbic acid content, polyphenol content and anthocyanin content were also measured from the fresh and dried radish. Thick slices (5mm) were made for tray dryer and thin slices (3mm) were made for freeze dryer. The moisture content (MC) decreased with drying temperature for both the thick and thin slices in each dryer. The retention of nutrient content was found decreased in the samples dried at higher temperature. The nutrient loss can be reduced by selection of proper temperature for drying. The antioxidant constituents in dried radish were decreased with higher temperature as compared with fresh sample. There was nohuge change on the ascorbic acid, polyphenol and anthocyanin contents of dried radish when dried at (60 0 C ) in tray dryer and (-50 0 C) in freeze dryer. But there was about slight decrease in the ascorbic acid, polyphenol and anthocyanin content in radish after drying at different temperatures

Perspectives of the Apiaceae Hepatoprotective Effects - A Review

The liver has the crucial role in the regulation of various physiological processes and in the excretion of endogenous waste metabolites and xenobiotics. Liver structure impairment can be caused by various factors including microorganisms, autoimmune diseases, chemicals, alcohol and drugs. The plant kingdom is full of liver protective chemicals such as phenols, coumarins, lignans, essential oils, monoterpenes, carotenoids, glycosides, flavonoids, organic acids, lipids, alkaloids and xanthenes. Apiaceae plants are usually used as a vegetable or as a spice, but their other functional properties are also very important. This review highlights the significance of caraway, dill, cumin, aniseed, fennel, coriander, celery, lovage, angelica, parsley and carrot, which are popular vegetables and spices, but possess hepatoprotective potential. These plants can be used for medicinal applications to patients who suffer from liver damage

GZ17-6.02 Inhibits the Growth of EGFRvIII+ Glioblastoma

Epidermal Growth Factor Receptor (EGFR) is amplified in over 50% of glioblastomas and promotes tumor formation and progression. However, attempts to treat glioblastoma with EGFR tyrosine kinase inhibitors have been unsuccessful thus far. The current standard of care is especially poor in patients with a constitutively active form of EGFR, EGFRvIII, which is associated with shorter survival time. This study examined the effect of GZ17-6.02, a novel anti-cancer agent undergoing phase 1 studies, on two EGFRvIII+ glioblastoma stem cells: D10-0171 and D317. In vitro analyses showed that GZ17-6.02 inhibited the growth of both D10-0171 and D317 cells with IC50 values of 24.84 and 28.28 µg/mL respectively. RNA sequencing and reverse phase protein array analyses revealed that GZ17-6.02 downregulates pathways primarily related to steroid synthesis and cell cycle progression. Interestingly, G17-6.02’s mechanism of action involves the downregulation of the recently identified glioblastoma super-enhancer genes WSCD1, EVOL2, and KLHDC8A. Finally, a subcutaneous xenograft model showed that GZ17-6.02 inhibits glioblastoma growth in vivo. We conclude that GZ17-6.02 is a promising combination drug effective at inhibiting the growth of a subset of glioblastomas and our data warrants further preclinical studies utilizing xenograft models to identify patients that may respond to this drug